Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lucia Knopfová"'
Autor:
Kamila Říhová, Monika Dúcka, Iva Staniczková Zambo, Ladislava Vymětalová, Martin Šrámek, Filip Trčka, Jan Verner, Stanislav Drápela, Radek Fedr, Tereza Suchánková, Barbora Pavlatovská, Eva Ondroušková, Irena Kubelková, Danica Zapletalová, Štěpán Tuček, Peter Múdry, Dagmar Adámková Krákorová, Lucia Knopfová, Jan Šmarda, Karel Souček, Lubor Borsig, Petr Beneš
The transcription factor c-Myb is an oncoprotein promoting cell proliferation and survival when aberrantly activated/expressed, thus contributing to malignant transformation. Overexpression of c-Myb has been found in leukemias, breast, colon and aden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b04ff593300ff6bdf0cde2b3cfb8ff
https://www.zora.uzh.ch/id/eprint/226453/
https://www.zora.uzh.ch/id/eprint/226453/
Autor:
Petr Beneš, Jiří Jarkovský, Jana Katolická, Ivan Čapov, Jan Šmarda, Petr Vlček, Tichý M, Markéta Hermanová, Lucia Knopfová
Publikováno v:
Journal of Cancer
Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expr
Autor:
Lubor Borsig, Darya Protsyuk, Sandra Grässle, Volker Huck, Irina Häuselmann, Alexander Bauer, Marko Roblek, Stefan W. Schneider, Lucia Knopfová
Publikováno v:
Cancer Research
Tumor cells interact with blood constituents and these interactions promote metastasis. Selectins are vascular receptors facilitating interactions of tumor cells with platelets, leukocytes, and endothelium, but the role of endothelial E-selectin rema
Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma
Autor:
Lenka Veverková, Jiří Jarkovský, Ivan Čapov, Petr Beneš, Jana Katolická, Jan Šmarda, Markéta Hermanová, Lucie Pekarčíková, Petr Vlček, Tichý M, Lucia Knopfová
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
The MYB gene codes for the c-Myb transcription factor maintaining proliferation of colon epithelial progenitors, thus controlling colon development and homeostasis. This gene is overexpressed in early phases of colorectal cancer (CRC) tumorigenesis.
Autor:
Lubor Borsig, Cristina Stefanescu, Lucia Knopfová, Jesus Francisco Glaus Garzon, Darya Protsyuk, Christian Gorzelanny, Bruno Luckow, Marko Roblek, Stefan W. Schneider, Mathias Heikenwalder, Paul F. Becker
Publikováno v:
Mol. Cancer Res. 17, 783-793 (2019)
Increased levels of the chemokine CCL2 in cancer patients are associated with poor prognosis. Experimental evidence suggests that CCL2 correlates with inflammatory monocyte recruitment and induction of vascular activation, but the functionality remai
Autor:
Vojtech Adam, Petr Babula, Monika Holubová, Martina Raudenská, Markéta Sztalmachová, Michal Masarik, Jaromír Gumulec, Jan Balvan, Hana Polanska, René Kizek, Lucia Knopfová, Kristyna Hudcova
Publikováno v:
International Journal of Oncology. 46:1810-1818
Breast cancer patients negative for the nuclear oestrogen receptor α have a particularly poor prognosis. Therefore, the 4T1 cell line (considered as a triple-negative model) was chosen to induce malignancy in mice. The aim of the present study was t
Publikováno v:
Klinicka onkologie. 27:S22-S27
Migration and invasiveness are phenotypic characteristics of cells that contribute to physiological processes, such as wound healing or embryogenesis and they are involved in serious pathological processes, namely in tumor cell metastasis. Availabili
Autor:
Lucia Janáčová, Jakub Faktor, Petr Beneš, Pavel Bouchal, Lucia Knopfová, Pavel Fabian, Lenka Čápková
Publikováno v:
ESMO Open. 3:A115-A116
Introduction Catechol-O-methyltransferase (COMT) plays an essential role in detoxification of catechols by transferring the methyl group from S-adenosyl-l-methionine to the substrate. In breast cancer, it catalyses methylation of oestrogen metabolite
Autor:
Michal Masarik, Veronika Dvorakova, Martina Raudenská, Hana Polanska, René Kizek, Vojtech Adam, Jaromír Gumulec, Kristyna Hudcova, Lucia Knopfová, Jan Balvan, Petr Babula, Branislav Ruttkay-Nedecky, Marie Stiborová, Markéta Sztalmachová
Publikováno v:
International Journal of Oncology. 44:923-933
Differences in the antioxidant system, apoptotic mechanism and in cell cycle between prostatic cell lines could partially elucidate the development of cisplatin resistance. The aim of this study was to identify the most characteristic parameter for a
Autor:
Lucia Knopfová, Eva Slabáková, Jan Bouchal, Ján Remšík, Gvantsa Kharaishvili, Petr Beneš, Lucia Binó, Tereza Nehybová, Radek Fedr, Šárka Šimečková, Karel Souček, Milan Král, Zuzana Kahounová
Publikováno v:
Cancer Research. 78:B084-B084
Dissemination of cancer cells to distant organs has fatal consequences to most of the patients with malignant tumors. Patients with prostate and breast cancer show apparent overlap of the most common sites of cancer metastasis, suggesting that breast