Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Guillem Argiles"'
Autor:
Benoit Rousseau, Ivan Bieche, Eric Pasmant, Nadim Hamzaoui, Nicolas Leulliot, Lucas Michon, Aurelien de Reynies, Valerie Attignon, Michael B. Foote, Julien Masliah-Planchon, Magali Svrcek, Romain Cohen, Victor Simmet, Paule Augereau, David Malka, Antoine Hollebecque, Damien Pouessel, Carlos Gomez-Roca, Rosine Guimbaud, Amandine Bruyas, Marielle Guillet, Jean-Jacques Grob, Muriel Duluc, Sophie Cousin, Christelle de la Fouchardiere, Aude Flechon, Frederic Rolland, Sandrine Hiret, Esma Saada-Bouzid, Olivier Bouche, Thierry Andre, Diane Pannier, Farid El Hajbi, Stephane Oudard, Christophe Tournigand, Jean-Charles Soria, Stephane Champiat, Drew G. Gerber, Dennis Stephens, Michelle F. Lamendola-Essel, Steven B. Maron, Bill H. Diplas, Guillem Argiles, Asha R. Krishnan, Severine Tabone-Eglinger, Anthony Ferrari, Neil H. Segal, Andrea Cercek, Natalie Hoog-Labouret, Frederic Legrand, Clotilde Simon, Assia Lamrani-Ghaouti, Luis A. Diaz, Pierre Saintigny, Sylvie Chevret, Aurelien Marabelle
Publikováno v:
Cancer Discov
Missense mutations in the polymerase epsilon (POLE) gene have been reported to generate proofreading defects resulting in an ultramutated genome and to sensitize tumors to checkpoint blockade immunotherapy. However, many POLE-mutated tumors do not re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8e899f23de8fd5ae08205569ea39ac
https://europepmc.org/articles/PMC9167784/
https://europepmc.org/articles/PMC9167784/
Autor:
Manish R. Patel, Luna Musib, Paul Conkling, Andrés Cervantes, Premal Patel, Kedan Lin, Nicholas J. Vogelzang, Ari David Baron, Johanna C. Bendell, J-C. Soria, Maha Hussain, Daniel J. Maslyar, Wai Y. Chan, Josep Tabernero, N. Xu, Steven J. Isakoff, Guillem Argiles, L. R. Molife, Han Ma, Deepak Sampath, Steven Gendreau
Publikováno v:
Scientia
Annals of oncology : official journal of the European Society for Medical Oncology
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Annals of oncology : official journal of the European Society for Medical Oncology
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Inhibidor d'AKT; Càncer avançat; Fase I Inhibidor de AKT; Cáncer avanzado; Fase I AKT inhibitor; Advanced cancer; Phase I Background This phase Ib study evaluated the safety, tolerability, pharmacokinetics, and preliminary efficacy of the oral AKT
Autor:
Matthias P. Ebert, Patrick Dicker, Livio Trusolino, Jochen H. M. Prehn, Adam Lafferty, Elodie Modave, Alice C. O’Farrell, Enzo Medico, Giorgia Migliardi, Niraj Khemka, Rodrigo Dienstmann, Evy Vanderheyden, Andrea Bertotti, Francesco Sassi, Claudio Isella, Eugenia R. Zanella, Diether Lambrechts, Guillem Argiles, Josep Tabernero, Manuela Salvucci, Annette T. Byrne, Johannes Betge, Luise Halang, Bram Boeckx, Andreas U. Lindner
Publikováno v:
Clin Cancer Res
Purpose: Regorafenib (REG) is approved for the treatment of metastatic colorectal cancer, but has modest survival benefit and associated toxicities. Robust predictive/early response biomarkers to aid patient stratification are outstanding. We have ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bd59b844860eb48b47b1d2324f5576
https://zenodo.org/record/7798369
https://zenodo.org/record/7798369
Autor:
Benoît Rousseau, Ivan Bieche, Eric Pasmant, Nadim Hamzaoui, Nicolas Leulliot, Lucas Michon, Aurelien de Reynies, Mike Foote, Julien Masliah-Planchon, Magali Svrcek, Romain Cohen, Victor Simmet, Paule Augereau, David Malka, Antoine Hollebecque, Damien Pouessel, Carlos Gomez-Roca, Rosine Guimbaud, Amandine Bruyas, Marielle Guillet, Muriel Duluc, Sophie Cousin, Christelle de la Fourchardiere, Frederic Rolland, Sandrine Hiret, Esma Saada-Bouzid, Olivier Bouche, Thierry Andre, Diane Pannier, Farid El Hajbi, Stephane Oudard, Christophe Tournigand, Jean-Charles Soria, Drew Gerber, Dennis Stephens, Michelle Lamandola-Essel, Steven B Maron, Bill Diplas, Guillem Argiles, Asha Krishnan, Neil Segal, Andrea Cercek, Nathalie Hoog-Labouret, Frederic Legrand, Clotide Simon, Assia Lamrani-Ghaouti, Luis A. Diaz, Pierre Saintigny, Sylvie Chevret, Aurelien Marabelle
Publikováno v:
Cancer Research. 82:CT021-CT021
Context: Polymerase epsilon (POLE) gene missense hotspot mutations can generate pathogenic (p) proofreading defects resulting in hypermutated genomic profiles. Aim: Determine the prevalence, genomic consequences and immunotherapy sensitivity of advan
Autor:
Ronan Fougeray, Mark P Saunders, Catherine Leger, Antoine Hollebecque, Laetitia Dahan, Gerald W. Prager, Julien Edeline, Alexander Stein, Gábor Rubovszky, Alessandra Auriemma, Zsuzsanna Papai, Roberto Bordonaro, Aitana Calvo, Antonio Cubillo, Guillem Argiles, V. Cattan, Thierry André, Nadia Amellal, Josep Tabernero
Publikováno v:
ESMO Open
ESMO Open, European Society for Medical Oncology, 2021, 6 (5), pp.100270. ⟨10.1016/j.esmoop.2021.100270⟩
ESMO Open, 2021, 6 (5), pp.100270. ⟨10.1016/j.esmoop.2021.100270⟩
Scientia
ESMO Open, European Society for Medical Oncology, 2021, 6 (5), pp.100270. ⟨10.1016/j.esmoop.2021.100270⟩
ESMO Open, 2021, 6 (5), pp.100270. ⟨10.1016/j.esmoop.2021.100270⟩
Scientia
Background In preclinical studies trifluridine/tipiracil (FTD/TPI) plus oxaliplatin (Industriestrasse, Holzkirchen, Germany) sensitised microsatellite stable (MSS) metastatic colorectal cancer (mCRC) to anti-programmed cell death protein-1; the addit
Autor:
Ana Vivancos, Analia Azaro, Elena Garralda, Cristina Santos, Rodrigo Dienstmann, Guillem Argiles, Giulia Martini, Josep Tabernero, Susana Aguilar, Paolo Nuciforo
Publikováno v:
JCO Precision Oncology. :1-3
Autor:
Andrés Cervantes, Aitana Calvo, Ronan Fougeray, Josep Tabernero, Antoine Hollebecque, Thierry André, Guillem Argiles, Catherine Leger, Nadia Amellal, Laetitia Dahan
Publikováno v:
European Journal of Cancer. 112:12-19
Background and objectives Pre-clinical data have shown that combining trifluridine/tipiracil with oxaliplatin enhances anti-tumour activity compared with either monotherapy. A phase I dose-escalation study was conducted to determine the maximum toler
Autor:
Nuria Mulet, Guillem Argiles, Elena Elez, Alba Noguerido, Josep Tabernero, Ignacio Matos, Javier Ros
Publikováno v:
Expert Opinion on Investigational Drugs. 28:463-471
INTRODUCTION The addition of monoclonal antibody (mAb) epidermal growth factor receptor (EGFR) inhibitors to classic chemotherapy doublet backbones has improved survival of metastatic colorectal cancer (mCRC). However, the role of triple-drug chemoth
Autor:
Thibaud Valentin, Jorge L. Iglesias, Arturo Soto Matos-Pita, Elena Elez, Josep Tabernero, Carlos Gomez-Roca, Teresa Macarulla, Salvador Fudio, Katrin Zaragoza, Guillem Argiles, Cinthya Coronado, Jean-Pierre Delord, Sarah Betrian
Publikováno v:
Investigational New Drugs. 37:674-683
Background Plocabulin (PM060184) is a novel marine-derived microtubule inhibitor that acts as an antitumor agent. This first-in-human study evaluated dose-limiting toxicities (DLT) to define the maximum tolerated dose (MTD) and phase II recommended d
Autor:
Guillem Argiles, Giulia Martini, Emilia Sardo, Davide Ciardiello, Josep Tabernero, Nuria Mulet, Javier Ros, Francesc Salvà, Elena Elez, Iosune Baraibar, Jose Luis Cuadra
Publikováno v:
Therapeutic Advances in Medical Oncology
Scientia
Scientia
Inhibidor de BRAF; Binimetinib; Cáncer de colon BRAF inhibitor; Binimetinib; Colon cancer Inhibidor de BRAF; Binimetinib; Càncer de còlon Introduction: BRAF driver mutations are found in up to 15% of patients with colorectal cancer (CRC) and lead