Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Danny V Jeyaraju"'
Autor:
Neil MacLean, Shawn Brennan, Adam C. Smith, Rose Hurren, Allison Berger, Xiaoming Wang, Razq Hakem, Marcela Gronda, Mark D. Minden, Sara Farshchi Zarabi, Simon Kavanagh, Tary Traore, G. Wei Xu, Aaron D. Schimmer, Emil F. Pai, Samir H. Barghout, Ondrej Halgas, Michael Milhollen, Marc L. Hyer, Parasvi S. Patel, Danny V. Jeyaraju
Publikováno v:
Leukemia. 33:37-51
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy for which new therapeutic approaches are required. One such potential therapeutic strategy is to target the ubiquitin-like modifier-activating enzyme 1 (UBA1), the initiating enzyme
Autor:
Rose Hurren, Ashwin Ramakrishnan, Gary D. Bader, Veronique Voisin, Danny V. Jeyaraju, Mark D. Minden, Marcela Gronda, Aaron D. Schimmer, Neil MacLean
Publikováno v:
Molecular Cancer Research. 14:A87-A87
Recently, we demonstrated that a subset of AML cells and stem cells have metabolic vulnerabilities in the mitochondria and oxidative phosphorylation (OXPHOS) chain that could impact on the ability of AML and AML stem cells to handle increased electro
Autor:
Danny V. Jeyaraju, Aaron D. Schimmer, Rose Hurren, Mark D. Minden, Aisha Shamas-Din, Marcela Gronda, Neil MacLean, Guri Giaever, Xiaoming Wang
Publikováno v:
Oncotarget
The isoflavone ME-344 is a potent anti-cancer agent with preclinical efficacy in solid tumors in vitro and in vivo. In a recently completed phase I clinical trial in patients with refractory solid tumors, ME-344 was well tolerated and clinical respon
Autor:
Yi Hua Qia, Nianxian Zhang, Elisa Leung, Walid A. Houry, Mark D. Minden, Chang Jiang Xu, Rachel Mattson, Sonja Babovic, Marcela Gronda, Kevin R. Combes, Troy Ketela, Mahadeo A. Sukhai, Jason Moffat, Rose Hurren, Fengshu Lin, Shaheena Bashir, Rima Al-awar, John E. Dick, Veronique Voisin, Zhenyue Hao, Jean C.Y. Wang, Neil MacLean, Erno Wienholds, Etienne Coyaud, Xiaoming Wang, Wei Zheng, Ahmed Aman, Alicia Cole, Ashwin Ramakrishnan, Brian Raught, Gary D. Bader, Swayam Prabha, Steven M. Kornblau, Aaron D. Schimmer, Yulia Jitkova, Zezhou Wang, Connie J. Eaves, Ian Restall, Danny V. Jeyaraju
Publikováno v:
Cancer Cell. (6):864-876
SummaryFrom an shRNA screen, we identified ClpP as a member of the mitochondrial proteome whose knockdown reduced the viability of K562 leukemic cells. Expression of this mitochondrial protease that has structural similarity to the cytoplasmic proteo