Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Andrew J. Gifford"'
Autor:
Rebecca Daly, Kate Hetherington, Emily Hazell, Bethany R. Wadling, Vanessa Tyrrell, Katherine M. Tucker, Glenn M. Marshall, David S. Ziegler, Loretta M. S. Lau, Toby N. Trahair, Tracey A. O’Brien, Kiri Collins, Andrew J. Gifford, Michelle Haber, Mark Pinese, David Malkin, Mark J. Cowley, Jonathan Karpelowsky, Donna Drew, Chris Jacobs, Claire E. Wakefield
Publikováno v:
Journal of Personalized Medicine, Vol 13, Iss 7, p 1033 (2023)
Precision medicine programs aim to utilize novel technologies to identify personalized treatments for children with cancer. Delivering these programs requires interdisciplinary efforts, yet the many groups involved are understudied. This study explor
Externí odkaz:
https://doaj.org/article/ebb8f8472a954e148f3f353dc5bb6b5d
Autor:
Wakefield, Rebecca Daly, Kate Hetherington, Emily Hazell, Bethany R. Wadling, Vanessa Tyrrell, Katherine M. Tucker, Glenn M. Marshall, David S. Ziegler, Loretta M. S. Lau, Toby N. Trahair, Tracey A. O’Brien, Kiri Collins, Andrew J. Gifford, Michelle Haber, Mark Pinese, David Malkin, Mark J. Cowley, Jonathan Karpelowsky, Donna Drew, Chris Jacobs, Claire E.
Publikováno v:
Journal of Personalized Medicine; Volume 13; Issue 7; Pages: 1033
Precision medicine programs aim to utilize novel technologies to identify personalized treatments for children with cancer. Delivering these programs requires interdisciplinary efforts, yet the many groups involved are understudied. This study explor
Autor:
Jinhan Xie, Paulette Barahona, Michelle Haber, Emily Mould, Andrew J. Gifford, Loretta Lau, Amit Kumar, Timothy W. Failes, Marie Wong-Erasmus, Dylan Grebert-Wade, Greg M. Arndt, M. Emmy M. Dolman, Dong-Anh Khuong-Quang, Chelsea Mayoh, Kanika Bhatia, Shu-Oi Chow, Alvin Kamili, Roxanne Cadiz, Richard B. Lock, Maria Tsoli, Vanessa Tyrrell, David S. Ziegler, Glenn M. Marshall, Penny Athanasatos
Publikováno v:
Cancer Cytopathology. 129:805-818
Background The development of high-throughput drug screening (HTS) using primary cultures provides a promising, clinically translatable approach to tailoring treatment strategies for patients with cancer. However, this has been challenging for solid
Autor:
Laura D. Gamble, Ricky W. Johnstone, Klaartje Somers, Rachael L. Terry, Glenn M. Marshall, Andrei V. Gudkov, Sophie Allan, Georgina L. Eden, Jamie I. Fletcher, Frances K. Kusuma, Stephanie Alfred, Mawar Karsa, Adam Kearns, Michelle J. Henderson, Michelle Haber, Angelika Bongers, Katerina Gurova, Lin Xiao, Anahid Ehteda, Lei Zhai, Erin Mosmann, Katerina I. Leonova, Natalia Issaeva, Pooja Venkat, Aisling O'Connor, Alvin Kamili, David S. Ziegler, Ruby Pandher, Daniel R. Carter, Hazel Quek, Andrew J. Gifford, Jayne Murray, Chelsea Mayoh, Jessica A. Pettitt, Murray D. Norris, Jennifer Brand, Emma Ronca, Anthony J. Cesare
Publikováno v:
Clin Cancer Res
Purpose: We investigated whether targeting chromatin stability through a combination of the curaxin CBL0137 with the histone deacetylase (HDAC) inhibitor, panobinostat, constitutes an effective multimodal treatment for high-risk neuroblastoma. Experi
Autor:
Richard B. Lock, Michelle J. Henderson, Angelika Bongers, Tim Failes, Mawar Karsa, Anna Mariana, Laurence C. Cheung, Andrew J. Gifford, Angelika Kosciolek, Michelle Haber, Ursula R. Kees, Rosemary Sutton, Greg M. Arndt, Murray D. Norris, Klaartje Somers, Rishi S. Kotecha
Publikováno v:
Br J Cancer
BACKGROUND: The prognosis for high-risk childhood acute leukaemias remains dismal and established treatment protocols often cause long-term side effects in survivors. This study aims to identify more effective and safer therapeutics for these patient
Autor:
Toby Trahair, Carol Wadham, Zara Ali, Glenn M. Marshall, Emily Mould, Lisa T. Morgan, Mitali Fadia, Jinhan Xie, Jamie I. Fletcher, Lei Zhai, Ashleigh M. Fordham, Andrew J. Gifford, Karen L. MacKenzie, Robyn Lukeis, Hassina Massudi
Publikováno v:
British Journal of Cancer
BackgroundEpithelioid inflammatory myofibroblastic sarcoma (eIMS) is characterised by perinuclear ALK localisation, CD30 expression and early relapse despite crizotinib treatment. We aimed to identify therapies to prevent and/or treat ALK inhibitor r
Autor:
Loretta Lau, Mark J. Cowley, Paul G Ekert, Michael Rodriguez, Chelsea Mayoh, Richard J. Cohn, Velimir Gayevskiy, Marie Wong, Andrew J. Gifford, Mark Pinese, Amit Kumar, Mark Reynolds, Michelle Haber, David S. Ziegler, Vanessa Tyrrell, Michael C. Cox, Glenn M. Marshall, Dong-Anh Khuong-Quang, Emily Mould, Maria Tsoli
Publikováno v:
British Journal of Cancer
Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40% of infant HGG. Here we report the fir
Autor:
William Stevenson, Anthony J. Gill, Oliver Giles Best, Grace Gifford, Sara Gabrielli, Qian Chen, Yandong Shen, Andrew J. Gifford
Publikováno v:
Leukemialymphoma. 61(8)
Fatty acid synthesis is crucial in supporting the survival and proliferation of multiple forms of cancer. The high metabolic demands of fatty acid synthesis are regulated by the AMP-activated kinase and activity of the fatty acid synthase enzyme. In
Autor:
Mustafa Syed, Emmy D.G. Fleuren, Chelsea Mayoh, Velimir Gayevskiy, Richard B. Lock, Toby Trahair, Emilie E. Wilkie, Mark Pinese, Heather Tapp, Michelle Haber, Amit Kumar, Inigo Martincorena, Jonathan Baber, Alexandra Sherstyuk, Dylan Grebert-Wade, Rachel Bowen-James, Tracey A. O'Brien, Frank Alvaro, Marie Wong, Andrew J. Gifford, Luciano Dalla-Pozza, David S. Ziegler, Paul Wood, Murray D. Norris, Glenn M. Marshall, Marie Gauthier, David Thomas, Peter Priestley, Mark J. Cowley, Paul G Ekert, Nicholas G. Gottardo, M. Emmy M. Dolman, Vanessa Tyrrell, Dong Anh Khuong-Quang, Geoffry B. McCowage, Andrew S. Moore, Katherine M. Tucker, Emily Mould, Paulette Barahona, Judy Kirk, Loretta Lau, Seong Lin Khaw, Federico Abascal, Meera Warby, Elodie Manouvrier, Patricia Sullivan, Noemi A. Bolanos, Patrick Strong, Jordan R. Hansford
Publikováno v:
Nature medicine. 26(11)
The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from hi
Autor:
Emma Ramsay, Emanuele Valli, Murray D. Norris, Joshy George, Michelle Haber, MoonSun Jung, Angelika Bongers, Leanna Cheung, Michelle J. Henderson, Molly Clifton, Clare L. Scott, Catherine J. Kennedy, Anna deFazio, Jixuan Gao, Monique Topp, Gwo-Yaw Ho, Andrew J. Gifford, Matthew Wakefield, Amanda J. Russell, Klaartje Somers, David D.L. Bowtell
Publikováno v:
International journal of cancerREFERENCES. 147(8)
Epithelial ovarian cancer (EOC) is a complex disease comprising discrete histological and molecular subtypes, for which survival rates remain unacceptably low. Tailored approaches for this deadly heterogeneous disease are urgently needed. Efflux pump