Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Karen J. Dunbar, Tatiana A. Karakasheva, Qiaosi Tang, Gizem Efe, Eric W. Lin, Michael Harris, Varun Sahu, Uma M. Sachdeva, Jianhua Hu, Andres J. Klein-Szanto, Brian Henick, J. Alan Diehl, Hiroshi Nakagawa, Anil K. Rustgi
Publikováno v:
Molecular Cancer Research. :OF1-OF12
Cancer-associated fibroblasts (CAF) can promote tumor growth, metastasis, and therapeutic resistance in esophageal squamous cell carcinoma (ESCC), but the mechanisms of action remain elusive. Our objective was to identify secreted factor(s) that medi
Autor:
Kathy Q. Cai, Kerry S. Campbell, Tiffany Luong, Tatiana Pazina, Wafik S. El-Deiry, Allison N. Lau, Ruchi Malik, Débora Barbosa Vendramini-Costa, Harvey Hensley, Alexander Muir, Dustin Rollins, Ralph Francescone, Yan Zhou, Siddharth Balachandran, Edna Cukierman, Sapna Gupta, Karthik Devarajan, Warren D. Kruger, Huamin Wang, Roshan J. Thapa, Matthew G. Vander Heiden, Jessica Wagner, Yinfei Tan, Diana Restifo, Andres J. Klein-Szanto, Suraj Peri, Igor Astsaturov, Linara Gabitova, Janusz Franco-Barraza
Publikováno v:
PMC
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and lacks effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using multiplex data from patient tissue, three-dimensional coculturing in vit
Autor:
Gizem Efe, Qiaosi Tang, Katherine M. Cunningham, Kensuke Sugiura, Karen Dunbar, Kausik Regunath, Kensuke Suzuki, Andres J. Klein-Szanto, Lois Resnick-Silverman, James J. Manfredi, Carol L. Prives, Anil K. Rustgi
Publikováno v:
Cancer Research. 83:B014-B014
Introduction: Mutations of the tumor suppressor p53 are detected up to 80% of esophageal squamous cell carcinoma (ESCC) cases, which in turn correlate with high metastatic rates and poor prognosis. To understand the mutant p53-mediated mechanisms in
Autor:
Hiroshi Nakagawa, Takashi Kijima, Andres J. Klein-Szanto, Koji Tanaka, Kelly A. Whelan, Prasanna M. Chandramouleeswaran, Manti Guha, Gordon Ruthel, Satish Srinivasan, Narayan G. Avadhani, Maura M. Sheehan
Publikováno v:
Oncotarget
Esophageal squamous cell carcinoma (ESCC) is an aggressive cancer with late-stage detection and poor prognosis. This emphasizes the need to identify new markers for early diagnosis and treatment. Altered mitochondrial genome (mtDNA) content in primar
Autor:
Suraj Peri, Mitchell Cheung, Craig W. Menges, Eleonora Sementino, Andres J. Klein-Szanto, Yinfei Tan, Yuwaraj Kadariya, Kathy Q. Cai, Michael Slifker, Anna-Mariya Kukuyan, Frank J. Rauscher, Joseph R. Testa
Publikováno v:
Cancer Research. 79:4113-4123
Pleural malignant mesothelioma is a therapy-resistant cancer affecting the serosal lining of the thoracic cavity. Mutations/deletions of BAP1, CDKN2A, and NF2 are the most frequent genetic lesions in human malignant mesothelioma. We introduced variou
IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Autor:
Margaret C. Dunagin, Anil K. Rustgi, Qi Long, E. Paul Wileyto, David A. Frank, Andres J. Klein-Szanto, Varun Sahu, Todd J. Waldron, Sarah R. Walker, Edmund Qiao, Arjun Raj, Adam J. Bass, Kwok-Kin Wong, J. Alan Diehl, Shinya Ohashi, Kiichiro Baba, Qiaosi Tang, Devraj Basu, Zachary T. Giaccone, Eric W. Lin, Monica Soni, Tatiana A. Karakasheva
Publikováno v:
Cancer Research. 78:4957-4970
The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple cancer types, including upper-gastrointestinal (GI) cancers that currently lack effective therapeutic options. Cancer-associated fibroblasts (CAF) are an essential co
Autor:
Huamin Wang, Marina Pasca di Magliano, Nina Steele, Edna Cukierman, Janusz Franco-Barraza, Igor Astsaturov, Kerry S. Campbell, Tiffany Luong, Ralph Francescone, Benjamin L. Allen, Charline Ogier, Andres J. Klein-Szanto, Kathy Q. Cai, Debora Barbosa Vendramini Costa
Publikováno v:
Cancer Research. 81:PO-096
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer, with a 5-year survival of 10%. A major feature of PDAC is the presence of a dense fibrous stroma, due to the expansion of cancer associated fibroblasts (CAFs) and their
Autor:
Tiffany Luong, Kathy Q. Cai, Débora Barbosa Vendramini-Costa, Andres J. Klein-Szanto, Huamin Wang, Kerry S. Campbell, Janusz Franco-Barraza, Edna Cukierman, Ralph Francescone, Igor Astsaturov
Publikováno v:
Cancer Research. 81:116-116
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly types of cancer, with a 5-year survival of only 10%. One of the major features of PDAC is the dense fibrous stroma, due to the expansion of cancer associated fibroblasts (CAFs) and the
Autor:
Janusz Franco-Barraza, Débora Barbosa Vendramini-Costa, Igor Astsaturov, Andres J. Klein-Szanto, Tiffany Luong, Ralph Francescone, Kerry S. Campbell, Edna Cukierman, Huamin Wang, Kathy Q. Cai
Publikováno v:
Cancer Research. 81:LT019-LT019
Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest cancers, features a highly immunosuppressive environment, with expansion of cancer-associated fibroblasts (CAFs), and absence/inactivation of antitumor immune cells. Therefore, ways to man
Autor:
Timothy Ito, Andres J. Klein-Szanto, Jinfei Xu, Joseph R. Testa, David L. Wiest, Suraj Peri, Eleonora Sementino, Zemin Liu, Yinfei Tan, Kathy Q. Cai, Jianming Pei
Publikováno v:
Oncotarget
// Yinfei Tan 1, * , Eleonora Sementino 1, * , Jinfei Xu 1 , Jianming Pei 1 , Zemin Liu 1 , Timothy K. Ito 1 , Kathy Q. Cai 2 , Suraj Peri 3 , Andres J.P. Klein-Szanto 1, 2 , David L. Wiest 4 , Joseph R. Testa 1 1 Cancer Biology Program, Fox Chase Ca