Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Akiyoshi Komuro"'
Autor:
Suman Dash, Takeshi Ueda, Akiyoshi Komuro, Hisayuki Amano, Masahiko Honda, Masahito Kawazu, Hitoshi Okada
Publikováno v:
Molecular Cancer Research. 21:444-457
Pancreatic ductal adenocarcinoma (PDAC) is one of the most life-threatening malignancies. Although the deoxycytidine analog gemcitabine has been used as the first-line treatment for PDAC, the primary clinical challenge arises because of an eventual a
Autor:
Nobuhito Saito, Akiyoshi Komuro, Daizo Koinuma, Ryo Tanabe, Kohei Miyazono, Masato Morikawa, Satoshi Sakai, Erna Raja, Caname Iwata, Carl-Henrik Heldin, Tomoki Todo, Bengt Westermark
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 16, Iss 1, Pp 269-288 (2022)
Molecular Oncology, Vol 16, Iss 1, Pp 269-288 (2022)
Glioma‐initiating cells (GICs), a major source of glioblastoma recurrence, are characterized by the expression of neural stem cell markers and the ability to grow by forming nonadherent spheres under serum‐free conditions. Bone morphogenetic prot
Autor:
Daizo Koinuma, Akiyoshi Komuro, Masato Morikawa, Caname Iwata, Hiroyuki Mano, Yasushi Ino, Keiko Yuki, Kazunobu Isogaya, Nobuhito Saito, Akitake Mukasa, Hiroyuki Aburatani, Hitoshi Okada, Erna Raja, Kohei Miyazono, Manabu Soda, Melissa Ranjit, Tomoki Todo, Hiromichi Suzuki, Atsushi Natsume
Publikováno v:
International Journal of Cancer. 142:1627-1639
Glioblastoma is one of the most malignant forms of cancer, for which no effective targeted therapy has been found. Although The Cancer Genome Atlas has provided a list of fusion genes in glioblastoma, their role in progression of glioblastoma remains
Autor:
Akira Watanabe, Keiko Funa, Akiyoshi Komuro, Yasuyuki Morishita, Yuma Fuse, Mitsunobu R. Kano, Akifumi Hagiwara, Erik Johansson, Hiroyuki Aburatani, Kohei Miyazono, Caname Iwata
Publikováno v:
Cancer Science. 101:2398-2403
Diffuse-type gastric carcinoma is characterized by rapid progression and poor prognosis. High expression of transforming growth factor (TGF)-β and thick stromal fibrosis are observed in this type of gastric carcinoma. We have previously shown that d
Autor:
Yasuyuki Morishita, Akiyoshi Komuro, Koichi Sugimoto, Kunihiko Kiyono, Mitsunobu R. Kano, Kohei Miyazono, Hiroshi Suzuki, Hironori Matsuyama
Publikováno v:
Cancer Research. 69:8844-8852
Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates cell growth, differentiation, and apoptosis of various types of cells. Autophagy is emerging as a critical response of normal and cancer cells to environmental change
Autor:
Akira Watanabe, Hiroyuki Miyoshi, Akiyoshi Komuro, Yo Taro Shirai, Mitsunobu R. Kano, Masakazu Yashiro, Hiroyuki Aburatani, Kunihiko Kiyono, Kosei Hirakawa, Hiroshi Suzuki, Yasuyuki Morishita, Erik Johansson, Caname Iwata, Kohei Miyazono, Yoshiko Matsumoto
Publikováno v:
JNCI Journal of the National Cancer Institute
Background Diffuse-type gastric carcinoma is a cancer with poor prognosis that has high levels of transforming growth factor β (TGF-β) expression and thick stromal fibrosis. However, the association of TGF-β signaling with diffuse-type gastric car
Autor:
Kohei Miyazono, Kosei Hirakawa, Yasuyuki Morishita, Akiyoshi Komuro, Hiroshi Suzuki, Masakazu Yashiro, Caname Iwata, Kunihiko Kiyono, Mitsunobu R. Kano
Publikováno v:
Cancer science. 100(10)
c-Ski, originally identified as a proto-oncogene product, is an important negative regulator of transforming growth factor (TGF)-β family signaling through interaction with Smad2, Smad3, and Smad4. High expression of c-Ski has been found in some can
Autor:
Erik Johansson, Masako Oka, Caname Iwata, Masakazu Yashiro, Yasuyuki Morishita, Kosei Hirakawa, Akiyoshi Komuro, Kohei Miyazono, Kunihiko Kiyono, Michio Kaminishi, Mitsunobu R. Kano
Publikováno v:
Cancer research. 67(21)
Cyclooxygenase-2 (COX-2) inhibitor has been reported to suppress tumor progression. However, it is unclear whether this inhibitor can also prevent lymphatic metastasis. To determine the effects of COX-2 inhibitor on lymphatic metastasis, etodolac, a