Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Fay, K"'
Publikováno v:
Molecular Pharmacology. 63:119-127
The utility of oltipraz as a cancer chemopreventive agent is thought to depend on the induction of enzymes involved in phase 2 xenobiotic detoxification. Although studies of some enzymes induced by oltipraz implicate a novel transcriptional activatin
Publikováno v:
Drug Metabolism and Disposition. 30:324-330
Gunn rats glucuronidate acetaminophen (APAP) at reduced rates and show increased susceptibility to APAP-induced hepatotoxicity. This defect is presumed to involve UDP-glucuronosyltransferase (UGT) 1A6, which is nonfunctional in Gunn rats, but it is c
Autor:
Diana J. Auyeung, Fay K. Kessler, Andrew D. Grove, Robert A. Fisher, Melissa T. Thompson, Joseph K. Ritter
Publikováno v:
Hepatology. 30:476-484
In Crigler-Najjar type II patients and, recently, in Crigler-Najjar type I patients treated with human hepatocyte cell therapy, phenobarbital has been used for reducing the serum bilirubin load. Its effect is attributed to induction of the enzyme req
Publikováno v:
Journal of Biological Chemistry. 272:1621-1627
Previous work has shown that polycyclic aromatic hydrocarbons and oltipraz both induce an unidentified rat liver UDP-glucuronosyltransferase with activity toward benzo(a)pyrene-7, 8-diol, the proximate carcinogenic form of benzo(a)pyrene. Here we rep
Publikováno v:
Toxicology and applied pharmacology. 174(1)
UDP-glucuronosyltransferase 1A6 (UGT1A6), a key enzyme catalyzing the glucuronidation of small planar phenols and amines, is expressed in a tissue- and inducer-dependent manner. Expression is high in kidney, gastrointestinal tract, and induced liver,
Autor:
Fay K. Kessler, Joseph K. Ritter
Publikováno v:
Carcinogenesis. 18(1)
We report here that rats possess a hitherto unrecognized xenobiotic-inducible hepatic 7,8-dihydro-7,8-diol-benzo[a]pyrene (BPD) UDP-glucuronosyltransferase (UGT) activity. BPD UGT activity is induced in female F344 rat liver by treatment with the sel