Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Xinxin Ding"'
Publikováno v:
Toxicology and Applied Pharmacology. 272:598-607
We explored the mechanisms underlying the differential effects of two olfactory toxicants, the herbicide 2,6-dichlorobenzonitrile (DCBN) and the anti-thyroid drug methimazole (MMZ), on olfactory receptor neuron (ORN) regeneration in mouse olfactory e
Publikováno v:
Drug Metabolism and Disposition. 40:642-647
The aim of this study was to determine whether mouse CYP2A5 and CYP2F2 play critical roles in the bioactivation of 3-methylindole (3MI), a tissue-selective toxicant, in the target tissues, the nasal olfactory mucosa (OM) and lung. Five metabolites of
Autor:
Xinxin Ding, Melissa Behr, Kurunthachalam Kannan, Jun Gu, Yuichi Horii, Xin Zhou, Fang Xie, Cheng Fang
Publikováno v:
Toxicology and Applied Pharmacology. 249:101-106
The herbicide 2,6-dichlorobenzonitril (DCBN) is a potent and tissue-specific toxicant to the olfactory mucosa (OM). The toxicity of DCBN is mediated by cytochrome P450 (P450)-catalyzed bioactivation; however, it is not known whether target-tissue met
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 117:81-86
To better understand androgen function in the mammalian nose, we have determined the levels of testosterone (T) in the olfactory mucosa (OM, which harbors the olfactory receptor neurons) and the lateral nasal gland (LNG, which is the largest anterior
Autor:
Fang Xie, Xinxin Ding
Publikováno v:
Handbook of Olfaction and Gustation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b25e903118cbe5d8284117e42ab4872
https://doi.org/10.1002/9781118971758.ch3
https://doi.org/10.1002/9781118971758.ch3
Publikováno v:
Journal of Biological Chemistry. 279:27888-27895
Rat CYP2A3 and its mouse and human orthologs are expressed preferentially in the olfactory mucosa. We found previously that an element in the proximal promoter region of CYP2A3 (the nasal predominant transcriptional activating (NPTA) element), which
Autor:
Jun Gu, Huadong Cui, Pam Swiatek, Xiaoliang Zhuo, Xinxin Ding, Doris N. Collins, Melissa Behr, Qing Yu Zhang, Yingqiu Xie
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 308:719-728
CYP2G1 is a cytochrome P450 monooxygenase expressed uniquely in the olfactory mucosa (OM). We have generated Cyp2g1-null mice to identify the roles of CYP2G1 in the biology and the tissue-specific toxicity of xenobiotic compounds in the nose. Homozyg
Autor:
Jun Gu, Qing Yu Zhang, Li Shi, Dazi Liu, Ying Chen, Yi Qing Liu, Ting Su, Xiang Ren, Xinxin Ding
Publikováno v:
Biochemical Pharmacology. 66:1245-1251
The aim of the present study was to further characterize the expression of the CYP2A genes in human nasal mucosa. Fetal nasal tissues at 12-26 weeks of gestational age and surgical biopsy tissues from various regions of nasal cavity of adult patients
Publikováno v:
The FASEB Journal. 28
The aim of this study is to characterize the expression and activity of CYP2A13 and CYP2F1, two human P450 enzymes expressed preferentially in the respiratory tract. CYP2A and CYP2F enzymes have been reported to metabolize many lung toxicants, includ
Publikováno v:
Biochemical and Biophysical Research Communications. 289:1225-1228
The aim of this study was to determine whether the NPTA element of the olfactory mucosa-predominant CYP2A3 gene can be activated by NFI-A2, a recently identified member of the nuclear factor 1 family of transcription factors. Isoform-specific RNA-PCR