Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gina M. Peloso"'
Autor:
Tim B. Bigdeli, Roseann E. Peterson, Gina M. Peloso, Marijana Vujkovic, Rachel L. Kember, Olaoluwa O. Okusaga, Jared D. Bernard, Brian G. Mitchell, Annette Walder
ImportanceAs patients with schizophrenia or schizoaffective disorder have a high risk of suicide, and a history of suicide attempt is a strong predictor of suicide, determining whether history of suicide attempt is associated with COVID-19 in patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24d95d5f57be519c33670ba02d9c5818
https://doi.org/10.1101/2021.08.25.21262627
https://doi.org/10.1101/2021.08.25.21262627
Autor:
Diego Ardissino, Daniel J. Rader, Heribert Schunkert, Jeanette Erdmann, Danish Saleheen, Masa-aki Kawashiri, Hugh Watkins, Stacey Gabriel, Nilesh J. Samani, Akihiro Nomura, Namrata Gupta, Ruth McPherson, Pradeep Natarajan, Hong-Hee Won, Sekar Kathiresan, Svati H. Shah, Matthew J. Bown, John Danesh, Gina M. Peloso, Hayato Tada, Adolfo Correa, Roberto Elosua, Amit Khera, Connor A. Emdin
Background:Familial sitosterolemia is a rare Mendelian disorder characterized by hyperabsorption and decreased biliary excretion of dietary sterols. Affected individuals typically have complete genetic deficiency—homozygous loss-of-function (LoF) v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c6d4aece7d963e054c37e19249fb95
https://www.repository.cam.ac.uk/handle/1810/315239
https://www.repository.cam.ac.uk/handle/1810/315239
Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease
Autor:
Diego Ardissino, Daniel J. Rader, Gina M. Peloso, Hayato Tada, Masa-aki Kawashiri, Heribert Schunkert, Matthew J. Bown, Svati H. Shah, Stacey Gabriel, John Danesh, Ruth McPherson, Pradeep Natarajan, Danish Saleheen, Nilesh J. Samani, Adolfo Correa, Akihiro Nomura, Jeanette Erdmann, Amit Khera, Connor A. Emdin, Roberto Elosua, Sekar Kathiresan, Namrata Gupta, Hong-Hee Won, Hugh Watkins
BackgroundFamilial sitosterolemia is a rare, recessive Mendelian disorder characterized by hyperabsorption and decreased biliary excretion of dietary sterols. Affected individuals typically have complete genetic deficiency – homozygous loss-of-func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c60ec07d9935f33fe43516185c2a379
Autor:
Nora Franceschini, Lawrence F. Bielak, Anne B. Newman, Maryam Kavousi, Dennis O. Mook-Kanamori, Usman Baber, Shih-Jen Hwang, Lisa R. Yanek, Dermot F. Reilly, Amanda J. Cox, Sharon L.R. Kardia, Gerardo Heiss, Bob D. de Vos, Mika Kähönen, Pradeep Natarajan, Sekar Kathiresan, Mark O. Goodarzi, James G. Wilson, Joanna M. Wardlaw, Thomas H. Mosley, Donald W. Bowden, Dhananjay Vaidya, Nathan O. Stitziel, Michael A. Province, Bruce M. Psaty, Wendy Post, Gina M. Peloso, Jeffrey R. O'Connell, Laura M. Raffield, Stephen Turner, Patricia A. Peyser, Yii-Der Ida Chen, Hayato Tada, Joshua C. Bis, Kari E. North, Renée de Mutsert, Abbas Dehghan, Albert Hofman, Aaron Isaacs, Tamara B. Harris, Udo Hoffmann, Daniel J. Rader, Laura M. Yerges-Armstrong, Jessica van Setten, Kent D. Taylor, Matthijs Oudkerk, Braxton D. Mitchell, Xiuqing Guo, Aad van der Lugt, Harry J. de Koning, Vilmundur Gudnason, Riccardo E. Marioni, Cornelia M. van Duijn, Ingrid B. Borecki, Jerome I. Rotter, Oscar H. Franco, Roxana Mehran, Ivana Išgum, Pim A. de Jong, L. Adrienne Cupples, J. Wouter Jukema, Ruifang Li-Gao, Valentin Fuster, Fernando Rivadeneira, Ulf Schminke, Eric Boerwinkle, Alexander Teumer, Henry Völzke, Frits R. Rosendaal, Stefan Weiss, Leo-Pekka Lyytikäinen, Susan R. Heckbert, Jie Yao, Uwe Völker, James S. Pankow, Ian J. Deary, Stella Trompet, J. Jeffrey Carr, Mary K. Wojczynski, Christopher J. O'Donnell, Albert V. Smith, Mary F. Feitosa, Samantha Sartori, Stephan B. Felix, Ayse Demirkan, Olli T. Raitakari, Diane M. Becker, Terho Lehtimäki, Marcus Dörr, Khanh-Dung H. Nguyen, Brian G. Kral, Min A. Jhun, Rasika A. Mathias, André G. Uitterlinden, Dina Vojinovic, Lewis C. Becker, Najaf Amin, Lenore J. Launer, Joseph M. Massaro, Christina L. Wassel
Publikováno v:
Circulation: Cardiovascular Genetics, 9(6), 511
Circulation. Cardiovascular genetics, 9(6), 511-520. Lippincott Williams and Wilkins
Circulation-cardiovascular genetics, 9(6), 511-520. Lippincott Williams & Wilkins
Natarajan, P, Bis, J C, Bielak, L F, Cox, A J, Dörr, M, Feitosa, M F, Franceschini, N, Guo, X, Hwang, S-J, Isaacs, A, Jhun, M A, Kavousi, M, Li-Gao, R, Lyytikäinen, L-P, Marioni, R E, Schminke, U, Stitziel, N O, Tada, H, van Setten, J, Smith, A V, Vojinovic, D, Yanek, L R, Yao, J, Yerges-Armstrong, L M, Amin, N, Baber, U, Borecki, I B, Carr, J J, Chen, Y-D I, Cupples, L A, de Jong, P A, de Koning, H, de Vos, B D, Demirkan, A, Fuster, V, Franco, O H, Goodarzi, M O, Harris, T B, Heckbert, S R, Heiss, G, Hoffmann, U, Hofman, A, Išgum, I, Jukema, J W, Kähönen, M, Kardia, S L R, Kral, B G, Wardlaw, J M & Deary, I J & Wilson, J G 2016, ' Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis ', Circulation: Cardiovascular Genetics . https://doi.org/10.1161/CIRCGENETICS.116.001572
Circulation-Cardiovascular genetics, 9(6), 511. Lippincott Williams and Wilkins
Circulation : Cardiovascular Genetics, 9(6), 511-520. LIPPINCOTT WILLIAMS & WILKINS
Circulation-Cardiovascular Genetics, 9(6), 511-520. LIPPINCOTT WILLIAMS & WILKINS
Circulation. Cardiovascular genetics, vol 9, iss 6
Circulation. Cardiovascular genetics, 9(6), 511-520. Lippincott Williams and Wilkins
Circulation-cardiovascular genetics, 9(6), 511-520. Lippincott Williams & Wilkins
Natarajan, P, Bis, J C, Bielak, L F, Cox, A J, Dörr, M, Feitosa, M F, Franceschini, N, Guo, X, Hwang, S-J, Isaacs, A, Jhun, M A, Kavousi, M, Li-Gao, R, Lyytikäinen, L-P, Marioni, R E, Schminke, U, Stitziel, N O, Tada, H, van Setten, J, Smith, A V, Vojinovic, D, Yanek, L R, Yao, J, Yerges-Armstrong, L M, Amin, N, Baber, U, Borecki, I B, Carr, J J, Chen, Y-D I, Cupples, L A, de Jong, P A, de Koning, H, de Vos, B D, Demirkan, A, Fuster, V, Franco, O H, Goodarzi, M O, Harris, T B, Heckbert, S R, Heiss, G, Hoffmann, U, Hofman, A, Išgum, I, Jukema, J W, Kähönen, M, Kardia, S L R, Kral, B G, Wardlaw, J M & Deary, I J & Wilson, J G 2016, ' Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis ', Circulation: Cardiovascular Genetics . https://doi.org/10.1161/CIRCGENETICS.116.001572
Circulation-Cardiovascular genetics, 9(6), 511. Lippincott Williams and Wilkins
Circulation : Cardiovascular Genetics, 9(6), 511-520. LIPPINCOTT WILLIAMS & WILKINS
Circulation-Cardiovascular Genetics, 9(6), 511-520. LIPPINCOTT WILLIAMS & WILKINS
Circulation. Cardiovascular genetics, vol 9, iss 6
Background— The burden of subclinical atherosclerosis in asymptomatic individuals is heritable and associated with elevated risk of developing clinical coronary heart disease. We sought to identify genetic variants in protein-coding regions associa
Autor:
M.J. Budoff, Kevin Luk, Tamara B. Harris, Kathleen F. Kerr, Vilmundur Gudnason, George Thanassoulis, Mehdi Afshar, Jerome I. Rotter, Quenna Wong, Wendy S. Post, James C. Engert, Gina M. Peloso, Christopher J. O'Donnell, Stephen S. Rich, Line Dufresne, L. Adrienne Cupples, Ron Do, David S. Owens, Albert V. Smith
Background Mitral annular calcium (MAC), commonly identified by cardiac imaging, is associated with cardiovascular events and predisposes to the development of clinically important mitral valve regurgitation and mitral valve stenosis. However, its bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05217ed3d3a0d3c4ac35eda7fb85e292
https://europepmc.org/articles/PMC5538134/
https://europepmc.org/articles/PMC5538134/
Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease
Autor:
Danish Saleheen, Frederick E. Dewey, Gina M. Peloso, Peter S. Braund, Eric S. Lander, Hugh Watkin, Joseph B. Leader, Adolfo Correa, Amit Khera, Connor A. Emdin, Namrata Gupta, Rosanna Asselta, David J. Carey, Stacey Gabriel, Akihiro Nomura, Diego Ardissino, Thorsten Kessler, Daniel J. Rader, Nilesh J. Samani, H. Lester Kirchner, Martin Farrall, Colm O'Dushlaine, Ruth McPherson, Jaume Marrugat, Piera Angelica Merlini, Daniel R. Lavage, Roberto Elosua, Gonçalo R. Abecasis, Sekar Kathiresan, Hong-Hee Won, James G. Wilson, Heribert Schunkert, Cristen J. Willer, Michael F. Murray, Matthew J. Bown, Dustin N. Hartzel, Nathan O. Stitziel, Ingrid B. Borecki, Dajiang J. Liu, Stefano Duga, J. Neil Manus, Pradeep Natarajan, J Danesh, Alistair S. Hall
Publikováno v:
JAMA. 317(9)
Importance The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing triglyceride-rich lipoproteins from the circulation. Mutations that damage the LPL gene ( LPL ) lead to lifelong deficiency in enzymatic activity and can pro
Autor:
Shih-Jen Hwang, Udo Hoffmann, Sekar Kathiresan, Connie W. Tsao, Christopher J. O'Donnell, Gina M. Peloso, Sarah R. Preis, Caroline S. Fox, L. Adrienne Cupples
Publikováno v:
Journal of the American College of Cardiology. 60:2364-2371
Objectives This study evaluated the association of timing of lipid levels and lipid genetic risk score (GRS) with subclinical atherosclerosis. Background Atherosclerosis is a slowly progressive disorder influenced by suboptimal lipid levels. Long-ter
Autor:
John F. Thompson, Marju Orho-Melander, Mary Susan Burnett, Jürgen Schrezenmeir, Nour Eddine El Mokhtari, Christopher J. O'Donnell, Philipp S. Wild, Christina Willenborg, Stacey Gabriel, Yvonne T. van der Schouw, Maja Barbalić, Alistair S. Hall, Christopher Newton-Cheh, Michael Boehnke, Sonia S. Anand, Diederick E. Grobbee, Andreas Ziegler, Asif Rasheed, Bruna Gigante, Anne Tybjærg-Hansen, Heribert Schunkert, Kiran Musunuru, Jaume Marrugat, Vincent Mooser, Markku S. Nieminen, Pascal P. McKeown, Nicola Martinelli, Olaf H. Klungel, George Hindy, Cristen J. Willer, Anthonius de Boer, Li Chen, Diego Ardissino, Marja-Liisa Lokki, Ron Do, Karen L. Mohlke, Elena Gonzalez, John F. Peden, Shaun Purcell, Diether Lambrechts, Ruth Frikke-Schmidt, Mark J. Daly, Ida Surakka, Aarti Surti, Frans Van de Werf, Gina M. Peloso, Serkalem Demissie, Jolanda M. A. Boer, Gonçalo R. Abecasis, Aki S. Havulinna, W. M. Monique Verschuren, Hugh Watkins, Danish Saleheen, Bas J M Peters, Nilesh J. Samani, Inke R. König, Domenico Girelli, Markus Perola, Paul I.W. de Bakker, Juha Sinisalo, James C. Engert, Alexandre F.R. Stewart, Unnur Thorsteinsdottir, Keith A.A. Fox, Stefan Blankenberg, Muredach P. Reilly, Joseph M. Devaney, Anke-Hilse Maitland-van der Zee, Klaus Berger, Eric Boerwinkle, Marcus Fischer, Gudmundur Thorgeirsson, John A. Spertus, Clara C. Elbers, Daniel J. Rader, Stefan Schreiber, Arne Schäfer, Tanja Zeller, Erik Ingelsson, Arne Schillert, Jemma C. Hopewell, John Danesh, Ian Buysschaert, Toby Johnson, Samuli Ripatti, David S. Siscovick, Eric B. Rimm, Jeanette Erdmann, Sekar Kathiresan, Christian Hengstenberg, Olle Melander, Mingyao Li, Gudmar Thorleifsson, Roberto Elosua, Hilma Holm, Vera H.M. Deneer, Ruth McPherson, Benjamin F. Voight, Candace Guiducci, N. Charlotte Onland-Moret, Philippe M. Frossard, James P. Pirruccello, Cisca Wijmenga, Majken K. Jensen, Leena Peltonen, Ulf de Faire, Christopher Patterson, Diana Rubin, David Altshuler, Jose M. Ordovas, Eric L. Ding, Thomas M. Morgan, Pieter Willem Kamphuisen, Noël P. Burtt, Patrick Diemert, Robert Roberts, Pier Mannuccio Mannucci, Stephen E. Epstein, Stephen M. Schwartz, Kim Overvad, Monika Stoll, Veikko Salomaa, Robert Clarke, Kari Stefansson, Marten H. Hofker, L. Adrienne Cupples
Publikováno v:
Voight, B F, Peloso, G M, Orho-Melander, M, Frikke-Schmidt, R, Barbalic, M, Jensen, M K, Hindy, G, Hólm, H, Ding, E L, Johnson, T, Schunkert, H, Samani, N J, Clarke, R, Hopewell, J C, Thompson, J F, Li, M, Thorleifsson, G, Newton-Cheh, C, Musunuru, K, Pirruccello, J P, Saleheen, D, Chen, L, Stewart, A F R, Schillert, A, Thorsteinsdottir, U, Thorgeirsson, G, Anand, S, Engert, J C, Morgan, T, Spertus, J, Stoll, M, Berger, K, Martinelli, N, Girelli, D, McKeown, P P, Patterson, C C, Epstein, S E, Devaney, J, Burnett, M-S, Mooser, V, Ripatti, S, Surakka, I, Nieminen, M S, Sinisalo, J, Lokki, M-L, Perola, M, Havulinna, A, de Faire, U, Gigante, B, Ingelsson, E, Zeller, T, Wild, P, de Bakker, P I W, Klungel, O H, Maitland-van der Zee, A-H, Peters, B J M, de Boer, A, Grobbee, D E, Kamphuisen, P W, Deneer, V H M, Elbers, C C, Onland-Moret, N C, Hofker, M H, Wijmenga, C, Verschuren, W M M, Boer, J M A, van der Schouw, Y T, Rasheed, A, Frossard, P, Demissie, S, Willer, C, Do, R, Ordovas, J M, Abecasis, G R, Boehnke, M, Mohlke, K L, Daly, M J, Guiducci, C, Burtt, N P, Surti, A, Gonzalez, E, Purcell, S, Gabriel, S, Marrugat, J, Peden, J, Erdmann, J, Diemert, P, Willenborg, C, König, I R, Fischer, M, Hengstenberg, C, Ziegler, A, Buysschaert, I, Lambrechts, D, Van de Werf, F, Fox, K A, El Mokhtari, N E, Rubin, D, Schrezenmeir, J, Schreiber, S, Schäfer, A, Danesh, J, Blankenberg, S, Roberts, R, McPherson, R, Watkins, H, Hall, A S, Overvad, K, Rimm, E, Boerwinkle, E, Tybjaerg-Hansen, A, Cupples, L A, Reilly, M P, Melander, O, Mannucci, P M, Ardissino, D, Siscovick, D, Elosua, R, Stefansson, K, O'Donnell, C J, Salomaa, V, Rader, D J, Peltonen, L, Schwartz, S M, Altshuler, D & Kathiresan, S 2012, ' Plasma HDL cholesterol and risk of myocardial infarction : a mendelian randomisation study ', The Lancet, vol. 380, no. 9841, pp. 572-80 . https://doi.org/10.1016/S0140-6736(12)60312-2
Voight, B F, Peloso, G M, Orho-Melander, M, Frikke-Schmidt, R, Barbalic, M, Jensen, M K, Hindy, G, Hólm, H, Ding, E L, Johnson, T, Schunkert, H, Samani, N J, Clarke, R, Hopewell, J C, Thompson, J F, Li, M, Thorleifsson, G, Newton-Cheh, C, Musunuru, K, Pirruccello, J P, Saleheen, D, Chen, L, Stewart, A F, Schillert, A, Thorsteinsdottir, U, Thorgeirsson, G, Anand, S, Engert, J C, Morgan, T, Spertus, J, Stoll, M, Berger, K, Martinelli, N, Girelli, D, McKeown, P P, Patterson, C C, Epstein, S E, Devaney, J, Burnett, M-S, Mooser, V, Ripatti, S, Surakka, I, Nieminen, M S, Sinisalo, J, Lokki, M-L, Perola, M, Havulinna, A, de Faire, U, Gigante, B, Ingelsson, E, Zeller, T, Wild, P, de Bakker, P I W, Klungel, O H, Maitland-van der Zee, A-H, Peters, B J M, de Boer, A, Grobbee, D E, Kamphuisen, P W, Deneer, V H M, Elbers, C C, Onland-Moret, N C, Hofker, M H, Wijmenga, C, Verschuren, W M, Boer, J M, van der Schouw, Y T, Rasheed, A, Frossard, P, Demissie, S, Willer, C, Do, R, Ordovas, J M, Abecasis, G R, Boehnke, M, Mohlke, K L, Daly, M J, Guiducci, C, Burtt, N P, Surti, A, Gonzalez, E, Purcell, S, Gabriel, S, Marrugat, J, Peden, J, Erdmann, J, Diemert, P, Willenborg, C, König, I R, Fischer, M, Hengstenberg, C, Ziegler, A, Buysschaert, I, Lambrechts, D, Van de Werf, F, Fox, K A, El Mokhtari, N E, Rubin, D, Schrezenmeir, J, Schreiber, S, Schäfer, A, Danesh, J, Blankenberg, S, Roberts, R, McPherson, R, Watkins, H, Hall, A S, Overvad, K, Rimm, E, Boerwinkle, E, Tybjaerg-Hansen, A, Cupples, L A, Reilly, M P, Melander, O, Mannucci, P M, Ardissino, D, Siscovick, D, Elosua, R, Stefansson, K, O'Donnell, C J, Salomaa, V, Rader, D J, Peltonen, L, Schwartz, S M, Altshuler, D & Kathiresan, S 2012, ' Plasma HDL cholesterol and risk of myocardial infarction : a mendelian randomisation study ', Lancet, vol. 380, no. 9841, pp. 572-80 . https://doi.org/10.1016/S0140-6736(12)60312-2
LANCET, 380(9841), 572-580. ELSEVIER SCIENCE INC
Voight, B F, Peloso, G M, Orho-Melander, M, Frikke-Schmidt, R, Barbalic, M, Jensen, M K, Hindy, G, Hólm, H, Ding, E L, Johnson, T, Schunkert, H, Samani, N J, Clarke, R, Hopewell, J C, Thompson, J F, Li, M, Thorleifsson, G, Newton-Cheh, C, Musunuru, K, Pirruccello, J P, Saleheen, D, Chen, L, Stewart, A F, Schillert, A, Thorsteinsdottir, U, Thorgeirsson, G, Anand, S, Engert, J C, Morgan, T, Spertus, J, Stoll, M, Berger, K, Martinelli, N, Girelli, D, McKeown, P P, Patterson, C C, Epstein, S E, Devaney, J, Burnett, M-S, Mooser, V, Ripatti, S, Surakka, I, Nieminen, M S, Sinisalo, J, Lokki, M-L, Perola, M, Havulinna, A, de Faire, U, Gigante, B, Ingelsson, E, Zeller, T, Wild, P, de Bakker, P I W, Klungel, O H, Maitland-van der Zee, A-H, Peters, B J M, de Boer, A, Grobbee, D E, Kamphuisen, P W, Deneer, V H M, Elbers, C C, Onland-Moret, N C, Hofker, M H, Wijmenga, C, Verschuren, W M, Boer, J M, van der Schouw, Y T, Rasheed, A, Frossard, P, Demissie, S, Willer, C, Do, R, Ordovas, J M, Abecasis, G R, Boehnke, M, Mohlke, K L, Daly, M J, Guiducci, C, Burtt, N P, Surti, A, Gonzalez, E, Purcell, S, Gabriel, S, Marrugat, J, Peden, J, Erdmann, J, Diemert, P, Willenborg, C, König, I R, Fischer, M, Hengstenberg, C, Ziegler, A, Buysschaert, I, Lambrechts, D, Van de Werf, F, Fox, K A, El Mokhtari, N E, Rubin, D, Schrezenmeir, J, Schreiber, S, Schäfer, A, Danesh, J, Blankenberg, S, Roberts, R, McPherson, R, Watkins, H, Hall, A S, Overvad, K, Rimm, E, Boerwinkle, E, Tybjaerg-Hansen, A, Cupples, L A, Reilly, M P, Melander, O, Mannucci, P M, Ardissino, D, Siscovick, D, Elosua, R, Stefansson, K, O'Donnell, C J, Salomaa, V, Rader, D J, Peltonen, L, Schwartz, S M, Altshuler, D & Kathiresan, S 2012, ' Plasma HDL cholesterol and risk of myocardial infarction : a mendelian randomisation study ', Lancet, vol. 380, no. 9841, pp. 572-80 . https://doi.org/10.1016/S0140-6736(12)60312-2
LANCET, 380(9841), 572-580. ELSEVIER SCIENCE INC
BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic c
Autor:
Antti Jula, Heikki V. Huikuri, Faisal M. Merchant, Christopher J. O'Donnell, Arto Pietilä, Peter A. Noseworthy, Veikko Salomaa, Lasse Oikarinen, Christopher Newton-Cheh, Kennet Harald, Shih-Jen Hwang, Kimmo Porthan, Gina M. Peloso, Jani T. Tikkanen, Heikki Väänänen
Publikováno v:
Journal of the American College of Cardiology. 57(22):2284-2289
Objectives This study sought to describe the clinical correlates and heritability of the early repolarization pattern (ERP) in 2 large, population-based cohorts. Background There is growing recognition that ERP is associated with adverse outcomes. Me
Autor:
Catherine M. Phillips, Ross McManus, Helen M. Roche, Richard Planells, Sandrine Bertrais, Gina M. Peloso, Martyn R. Field, Jian Shen, Louisa Goumidi, Serge Hercberg, Denis Lairon
Publikováno v:
The Journal of Nutrition. 139:2011-2017
Signal transducer and activator of transcription 3 (STAT3) plays a key role in body weight regulation and glucose homeostasis, 2 important determinants of metabolic syndrome (MetS). Dietary fat is a key environmental factor that may interact with gen