Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Huck-Hui Ng"'
Autor:
LeeAnn Ramsay, Xinyi Lu, Pierre-Étienne Jacques, Friedrich Sachs, Guillaume Bourque, Jonathan Göke, Huck-Hui Ng
Publikováno v:
Nature Structural & Molecular Biology. 21:423-425
Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nucl
Autor:
Yun-Shen Chan, Galih Kunarso, Huck-Hui Ng, Justin Jeyakani, Catalina Hwang, Na-Yu Chia, Xinyi Lu, Guillaume Bourque
Publikováno v:
Nature Genetics. 42:631-634
Detection of new genomic control elements is critical in understanding transcriptional regulatory networks in their entirety. We studied the genome-wide binding locations of three key regulatory proteins (POU5F1, also known as OCT4; NANOG; and CTCF)
Autor:
Thomas Lufkin, Mikael Huss, Yuriy L. Orlov, Jian-Chien Dominic Heng, Petra Kraus, Jianyong Han, Jianming Jiang, Lin Yang, Bo Feng, Huck-Hui Ng, Jia-Hui Ng, Bing Lim
Publikováno v:
Cell Stem Cell. 6:167-174
SummarySomatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) with the introduction of Oct4, Sox2, Klf4, and c-Myc. Among these four factors, Oct4 is critical in inducing pluripotency because no transcription factor can substitut
Autor:
Jianyong Han, Paul Robson, Yuin-Han Loh, Mikael Huss, Ping Yuan, Yuriy L. Orlov, Huck-Hui Ng, Lai-Ping Yaw, Bing Lim, Guoji Guo
Publikováno v:
Genes & Development. 23:2507-2520
The histone H3 Lys 9 (H3K9) methyltransferase Eset is an epigenetic regulator critical for the development of the inner cell mass (ICM). Although ICM-derived embryonic stem (ES) cells are normally unable to contribute to the trophectoderm (TE) in bla
Publikováno v:
Stem Cells. 26:2759-2767
Identification of regulators governing the maintenance of embryonic stem (ES) cells is crucial to the understanding of ES cell biology. We identified a zinc finger protein, Zfp143, as a novel regulator for self-renewal. Depletion of Zfp143 by RNA int
Publikováno v:
Genes & Development. 21:2545-2557
Embryonic stem (ES) cells are pluripotent cells with the ability to self-renew indefinitely. These unique properties are controlled by genetic factors and chromatin structure. The exit from the self-renewing state is accompanied by changes in epigene
Autor:
Yixun Li, Yinan Wang, Yuin-Han Loh, Huck-Hui Ng, Xi Chen, Lawrence W. Stanton, Weiwei Zhang, Linda Shushan Lim, Manjiri Manohar Bakre
Publikováno v:
Molecular Biology of the Cell. 18:1348-1358
Embryonic stem (ES) cell pluripotency is dependent upon sustained expression of the key transcriptional regulators Oct4, Nanog, and Sox2. Dissection of the regulatory networks downstream of these transcription factors has provided critical insight in
Autor:
Yupo Ma, Boon Seng Soh, Bing Lim, Li Chai, Hsiao-Yun Chan, Wai Leong Tam, Paul Robson, Thomas Lufkin, Jianchang Yang, Qiang Wu, Yuefei Lou, Jinqiu Zhang, Huck-Hui Ng, Guo Qing Tong
Publikováno v:
Nature Cell Biology. 8:1114-1123
Embryonic stem (ES) cells are pluripotent cells that can self-renew or differentiate into many cell types. A unique network of transcription factors and signalling molecules are essential for maintaining this capability. Here, we report that a spalt
Autor:
Bing Lim, Joshy George, Joon Lin Chew, Vladimir A. Kuznetsov, Ken W. Sung, Kee Yew Wong, Yijun Ruan, Huck-Hui Ng, Qiang Wu, Xi Chen, Weiwei Zhang, Yuin-Han Loh, Jun Liu, Xiao Dong Zhao, Vinsensius B. Vega, Paul Robson, Bernard Leong, Kuo Ping Chiu, Leonard Lipovich, Chia-Lin Wei, Lawrence W. Stanton, Charlie W.H. Lee, Guillaume Bourque
Publikováno v:
Nature Genetics. 38:431-440
Oct4 and Nanog are transcription factors required to maintain the pluripotency and self-renewal of embryonic stem (ES) cells. Using the chromatin immunoprecipitation paired-end ditags method, we mapped the binding sites of these factors in the mouse
Autor:
Leng-Siew Yeap, Yuin-Han Loh, Xi Chen, Joon-Lin Chew, Pin Li, Yen-Sin Ang, Huck-Hui Ng, Wai Leong Tam, Paul Robson, Bing Lim, Wensheng Zhang
Publikováno v:
Molecular and Cellular Biology. 25:6031-6046
Embryonic stem cells (ESCs) are pluripotent cells that can either self-renew or differentiate into many cell types. Oct4 and Sox2 are transcription factors essential to the pluripotent and self-renewing phenotypes of ESCs. Both factors are upstream i