Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Hiroshi Sugiyama"'
Autor:
Yasuzumi Matsui, Yohei Mineharu, Yuki Noguchi, Etsuko Yamamoto Hattori, Hirohito Kubota, Masahiro Hirata, Susumu Miyamoto, Hiroshi Sugiyama, Yoshiki Arakawa, Yasuhiko Kamikubo
Publikováno v:
Biochemical and Biophysical Research Communications. 620:150-157
Malignancy of medulloblastoma depends on its molecular classification. Sonic Hedgehog (SHH)-type medulloblastoma with p53 mutation was recognized as one of the most aggressive types of tumors. We developed a novel drug, chlorambucil-conjugated PI-pol
Autor:
Huijuan Mao, Suresh Narva, Xiaoyin Zhao, Yoshimasa Tanaka, Chuanxin Guo, Xuqiong Xiong, Wang Ming, Xudong Ma, Kang Zhou, Wen Zhang, Yanling Wu, Jiachun Liu, Hiroshi Sugiyama
Publikováno v:
Journal of Medicinal Chemistry. 64:6021-6036
In recent years, PD-1 immune checkpoint inhibitors based on monoclonal antibodies have revolutionized cancer therapy, but there still exist unresolved issues, such as the high cost, the relatively low response rates, and so on, compared with small-mo
Publikováno v:
Chembiochem : a European journal of chemical biology. 23(14)
Pyrrole-imidazole polyamides (PIPs) bind to double-stranded DNA (dsDNA) with varied sequence selectivity. We synthesized linear PIPs that can bind to narrow minor grooves of polypurine/polypyrimidine sequences and target long recognition sequences bu
Autor:
Shintaro Funasaki, Sally Mehanna, Wenjuan Ma, Hidekazu Nishizawa, Yasuhiko Kamikubo, Hiroshi Sugiyama, Shuji Ikeda, Takanobu Motoshima, Hisashi Hasumi, W. Marston Linehan, Laura S. Schmidt, Chris Ricketts, Toshio Suda, Yuichi Oike, Tomomi Kamba, Masaya Baba
Publikováno v:
Cancer science. 113(7)
Renal cell carcinoma with Xp11.2 translocation involving the TFE3 gene (TFE3-RCC) is a recently identified subset of RCC with unique morphology and clinical presentation. The chimeric PRCC-TFE3 protein produced by Xp11.2 translocation has been shown
Publikováno v:
ChemBioChem. 22:1538-1545
Pyrrole-imidazole (PI) polyamides, which target specific DNA sequences, have been studied as a class of DNA minor-groove-binding molecules. To investigate the potential of compounds for cancer treatment, PI polyamides were conjugated with DNA-alkylat
Autor:
Debojyoti De, Gengo Kashiwazaki, Ganesh N. Pandian, Nazia Parveen, Jieun An, Junichi Taniguchi, Tong Mook Kang, Hiroshi Sugiyama, Kyeong Kyu Kim, Jin-A Lee
Publikováno v:
Journal of Cellular Physiology. 236:3946-3962
The epigenome has an essential role in orchestrating transcriptional activation and modulating key developmental processes. Previously, we developed a library of pyrrole-imidazole polyamides (PIPs) conjugated with suberoylanilide hydroxamic acid (SAH
Publikováno v:
Chemistry – A European Journal. 26:14639-14644
Many types of molecular targeted drugs that inhibit cancer growth by acting on specific molecules have been developed. The runt-related transcription factor (RUNX) family, which induces cancer development by binding to a specific DNA sequence, has at
Autor:
Yutaro Tsubono, Hiroshi Sugiyama, Ganesh N. Pandian, Kaori Hashiya, Takuya Hidaka, Yusuke Kawamoto, Toshikazu Bando
Publikováno v:
J Am Chem Soc
Telomeres are closely associated with cellular senescence and cancer. Although some techniques have been developed to label telomeres in living cells for study of telomere dynamics, few biocompatible near-infrared probes based on synthetic molecules
Publikováno v:
ChemBioChem. 23(2)
Abnormally expanded CAG/CTG repeat DNA sequences lead to a variety of neurological diseases, such as Huntington's disease. Here, we synthesized a cyclic pyrrole-imidazole polyamide (cPIP), which can bind to the minor groove of the CAG/CTG DNA sequenc
Publikováno v:
ChemBioChem. 21:2912-2915
We used N-methylpyrrole (Py)-N-methylimidazole-(Im) polyamide as an exogenous agent to modulate the formation of DNA assemblies at specific double-stranded sequences. The concept was demonstrated on the hybridization chain reaction that forms linear