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pro vyhledávání: '"Sandipan Brahma"'
Autor:
Sandipan, Brahma, Steven, Henikoff
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2477
Mapping the epigenome is key to describe the relationship between chromatin landscapes and the control of DNA-based cellular processes such as transcription. Cleavage under targets and release using nuclease (CUTRUN) is an in situ chromatin profiling
Autor:
Blaine Bartholomew, Swetansu K. Hota, Jim Persinger, Lola Olufemi, Saurabh K. Bhardwaj, Solomon G. Hailu, Soumyadipta Kundu, Sandipan Brahma
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Over the last 3 decades ATP-dependent chromatin remodelers have been thought to recognize chromatin at the level of single nucleosomes rather than higher-order organization of more than one nucleosome. We show the yeast ISW1a remodeler has such highe
Autor:
Sandipan Brahma, Steven Henikoff
Publikováno v:
Trends Biochem Sci
Gene regulation in eukaryotes requires the controlled access of sequence-specific transcription factors (TFs) to their sites in a chromatin landscape dominated by nucleosomes. Nucleosomes are refractory to TF binding, and often must be removed from r
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature Communications
Nuclear actin and actin-related proteins (Arps) are key components of chromatin remodeling and modifying complexes. Although Arps are essential for the functions of chromatin remodelers, their specific roles and mechanisms are unclear. Here we define
Autor:
Sandipan Brahma, Steven Henikoff
Publikováno v:
Molecular Cell. 73:238-249.e3
Summary The classic view of nucleosome organization at active promoters is that two well-positioned nucleosomes flank a nucleosome-depleted region (NDR). However, this view has been recently disputed by contradictory reports as to whether wider (≳1
Autor:
Mekonnen Lemma Dechassa, Arjan Hada, Solomon G. Hailu, Blaine Bartholomew, Sandipan Brahma, Payel Sen, Jie Luo, Jeff Ranish, Somnath Paul, Jim Persinger
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2135-2147 (2017)
Summary: The SWI/SNF chromatin remodeling complex is highly conserved from yeast to human, and aberrant SWI/SNF complexes contribute to human disease. The Snf5/SMARCB1/INI1 subunit of SWI/SNF is a tumor suppressor frequently lost in pediatric rhabdoi