Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Peter G.W. Gettins"'
Publikováno v:
Journal of Virology. 76:2848-2856
Tva is the cellular receptor for subgroup A avian sarcoma and leukosis virus (ASLV-A). The viral receptor function of Tva is determined by a 40-residue, cysteine-rich motif called the LDL-A module. Here we report the solution structure of the LDL-A m
Autor:
Angela Horne, Peter G.W. Gettins
Publikováno v:
Biochemistry. 31:2286-2294
The effects of length and composition upon the antithrombin-binding properties of heparin have been investigated for two series of structurally related heparin oligosaccharides. Each series consists of a tetrasaccharide, hexasaccharide, and octasacch
Autor:
Peter G.W. Gettins, Angela Horne
Publikováno v:
Carbohydrate Research. 225:43-57
Six heparin-derived oligosaccharides, ranging in size from di- to octa-saccharide and forming two closely related series different in structure by the substitution of an unsulfated d -glucuronate for a 2-sulfated l -iduronate residue, have been chara
Autor:
Peter G.W. Gettins, Angela Horne
Publikováno v:
Carbohydrate Research. 223:81-98
Two tetrasaccharides, two hexasaccharides, and a disaccharide have been purified from heparinase digests of porcine intestinal mucosal heparin in sufficient quantities to permit 13 C-n.m.r. characterization of the species. The two tetrasacchrides are
Autor:
S A Wardlaw, Peter G.W. Gettins
Publikováno v:
Journal of Biological Chemistry. 266:3422-3426
A 77Se-containing moiety has been attached to cysteine residues in bovine hemoglobin, reduced ribonuclease A, and glutathione by reaction with [77Se]6,6'-diselenobis(3-nitrobenzoic acid). The resultant species contain Se-S linkages that have 77Se NMR
Autor:
Peter G.W. Gettins, L Sottrup-Jensen
Publikováno v:
Journal of Biological Chemistry. 265:7268-7272
NMR and ESR spectroscopies have been used to examine the plasma protease inhibitor pregnancy zone protein (PZP) and its complex with chymotrypsin. The 1H NMR spectrum of PZP shows relatively few sharp resonances, which, by analogy with human alpha 2-
Autor:
Peter G.W. Gettins, Steven T. Olson
Publikováno v:
Methods (San Diego, Calif.). 32(2)
One of the important questions in the serpin mechanism of inhibition of serine and cysteine proteinases of different specificities and structural classes is whether a common “crushing” mechanism of proteinase inactivation is used in all cases. Th
Autor:
József Dobó, Peter G.W. Gettins
Publikováno v:
The Journal of biological chemistry. 279(10)
Despite several concordant structural studies on the initial non-covalent complex that serpins form with target proteinases, a recent study on the non-covalent complex between the serpin α1-proteinase inhibitor (α1PI) and anhydroelastase (Mellet, P
Publikováno v:
Biochemistry. 40(21)
We describe here the high-level expression of bovine trypsinogen in E. coli, its refolding and activation to beta-trypsin, and the selective incorporation of (15)N-labeled alanine through supplementation of the growth medium. Using this procedure, we
Publikováno v:
The Journal of biological chemistry. 275(2)
Human alpha(2)-macroglobulin-proteinase complexes bind to their receptor, the low density lipoprotein receptor-related protein (LRP), through a discrete 138-residue C-terminal receptor binding domain (RBD), which also binds to the beta-amyloid peptid