Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mitsuhiko Ikura"'
Autor:
Teklab Gebregiworgis, Christopher B. Marshall, Fenneke KleinJan, Geneviève M.C. Gasmi-Seabrook, Ben J Eves, Masahiro Enomoto, Ningdi F Liu, Ki-Young Lee, Mitsuhiko Ikura, Zhenhao Fang
Publikováno v:
Journal of Biomolecular NMR. 74:531-554
Mutations in RAS oncogenes occur in ~ 30% of human cancers, with KRAS being the most frequently altered isoform. RAS proteins comprise a conserved GTPase domain and a C-terminal lipid-modified tail that is unique to each isoform. The GTPase domain is
Autor:
Noboru Ishiyama, Le Zheng, Peter B. Stathopulos, Sung-In Back, Masahiro Enomoto, Tadateru Nishikawa, Mitsuhiko Ikura
Publikováno v:
Journal of molecular biology. 432(2)
Store operated calcium (Ca2+) entry (SOCE) is the process whereby endoplasmic reticulum (ER) Ca2+ store depletion causes Orai1-composed Ca2+ channels on the plasma membrane (PM) to open, mediating a rise in cytosolic Ca2+ levels. Stromal interaction
Autor:
Mitsuhiko Ikura, Dong Long, Lewis E. Kay, Mohammad T. Mazhab-Jafari, Guillaume Bouvignies, Matthew J. Smith, Christopher B. Marshall
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2013, 52 (41), pp.10771-10774. ⟨10.1002/anie.201305434⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2013, 52 (41), pp.10771-10774. ⟨10.1002/anie.201305434⟩
Angewandte Chemie International Edition, 2013, 52 (41), pp.10771-10774. ⟨10.1002/anie.201305434⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2013, 52 (41), pp.10771-10774. ⟨10.1002/anie.201305434⟩
The Ras superfamily of small GTPases are important intracellular signaling molecules, the functions of which are determined by the binding of guanosine nucleotides (GTP = guanosine triphosphate and GDP = guanosine diphosphate). [1] The GTP-bound (“
Publikováno v:
Biomolecular NMR assignments. 11(1)
α-Catenin is a filamentous actin (F-actin) binding protein that links the classical cadherin–catenin complex to the actin cytoskeleton at adherens junctions (AJs). Its C-terminal F-actin binding domain is required for regulating the dynamic intera
Autor:
Katsuhiko Mikoshiba, Franciose Haeseleer, James B. Ames, Mitsuhiko Ikura, Congmin Li, Jenny Chan, Krzysztof Palczewski
Publikováno v:
Journal of Biological Chemistry. 284:2472-2481
Calcium-binding protein 1 (CaBP1), a neuron-specific member of the calmodulin (CaM) superfamily, modulates Ca2+-dependent activity of inositol 1,4,5-trisphosphate receptors (InsP3Rs). Here we present NMR structures of CaBP1 in both Mg2+-bound and Ca2
Publikováno v:
Cell. 135:110-122
Summary Stromal interaction molecule-1 (STIM1) activates store-operated Ca 2+ entry (SOCE) in response to diminished luminal Ca 2+ levels. Here, we present the atomic structure of the Ca 2+ -sensing region of STIM1 consisting of the EF-hand and steri
Autor:
Mitsuhiko Ikura, Peter B. Stathopulos, Mohammad T. Mazhab-Jafari, Geneviève M.C. Gasmi-Seabrook, Benjamin G. Neel, Lewis E. Kay, Fuyuhiko Inagaki, Matthew J. Smith, Christopher B. Marshall
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(21)
K-RAS4B (Kirsten rat sarcoma viral oncogene homolog 4B) is a prenylated, membrane-associated GTPase protein that is a critical switch for the propagation of growth factor signaling pathways to diverse effector proteins, including rapidly accelerated
Autor:
Mitsuhiko Ikura, Francois Xavier Theillet, Matthew J. Smith, Christopher B. Marshall, Philipp Selenko, Andres Binolfi
Publikováno v:
Current opinion in structural biology. 32
Biological reactions occur in a highly organized spatiotemporal context and with kinetics that are modulated by multiple environmental factors. To integrate these variables in our experimental investigations of 'native' biological activities, we requ
Autor:
Thomas Acton, Tapas K. Mal, Mitsuhiko Ikura, G. V. T. Swapna, Ahmad Khorchid, Masanori Takayama, Haiping Ke, Sangita Phadtare, Bing Xia, Gaetano T. Montelione, Guoliang Qing, Li Chung Ma, Masayori Inouye
Publikováno v:
Nature Biotechnology. 22:877-882
Overexpression of proteins in Escherichia coli at low temperature improves their solubility and stability. Here, we apply the unique features of the cspA gene to develop a series of expression vectors, termed pCold vectors, that drive the high expres
Autor:
Mitsuhiko Ikura, Laura M. Elsby, Tapas K. Mal, Jane M. Gooding, Stefan G. E. Roberts, Mahua Ghosh
Publikováno v:
Biochemical Journal. 378:317-324
The general transcription factor, TFIIB, plays an important role in the assembly of the pre-initiation complex. The N-terminal domain (NTD) of TFIIB contains a zinc-ribbon motif, which is responsible for the recruitment of RNA polymerase II and TFIIF