Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kelly A. Whelan"'
Autor:
Medha Sharma, Veronique Giroux, Alain Benitez, Kathryn E. Hamilton, Anil K. Rustgi, Joshua Wang, Kelly A. Whelan, Andres J. Klein-Szanto, Jonathan M. Spergel, Hiroshi Nakagawa, Gary W. Falk, Prasanna M. Chandramouleeswaran, John W. Tobias, Amanda B. Muir, Koji Tanaka, Maureen DeMarshall, Yuta Kasagi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 333-352 (2018)
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 333-352 (2018)
Background & Aims Aberrations in the esophageal proliferation-differentiation gradient are histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease. A reliable protocol to grow 3-dimensional (3D) esophageal organoids
Autor:
Gary W. Falk, Kathryn E. Hamilton, Prasanna M. Chandramouleeswaran, Amanda B. Muir, Yuta Kasagi, Andres J. Klein-Szanto, Medha Sharma, Alain Benitez, Jonathan M. Spergel, Veronique Giroux, Maureen DeMarshall, Kelly A. Whelan, Hiroshi Nakagawa, Joshua Wang
Publikováno v:
Gastroenterology. 154:S-107
Autor:
Mitsuteru Natsuizaka, Phyllis A. Gimotty, Devraj Basu, Andres J. Klein-Szanto, Nicole D. Facompre, Ann Marie Egloff, Shingo Kagawa, Anil K. Rustgi, Seiji Naganuma, J A Diehl, Kelly A. Whelan, Kwok K. Wong, Shinya Ohashi, Hiroshi Nakagawa, Hideaki Kinugasa, Adam J. Bass
Publikováno v:
Oncogene
Notch activity regulates tumor biology in a context-dependent and complex manner. Notch may act as an oncogene or a tumor-suppressor gene even within the same tumor type. Recently, Notch signaling has been implicated in cellular senescence. Yet, it r
Autor:
Andres J. Klein-Szanto, Yoshiaki Kita, Naryan L. Rustgi, Devraj Basu, Mitsuteru Natsuizaka, Seiji Naganuma, Prasanna M. Chandramouleeswaran, Kelly A. Whelan, Shoji Natsugoe, Hiroshi Nakagawa, Shingo Kagawa, J. Alan Diehl, Adam J. Bass, Que Jianwen, Koji Tanaka
Publikováno v:
Cancer Research. 76:2678-2678
Introduction: Notch signaling may act as a tumor suppressor during the development of squamous cell carcinomas (SCCs); yet, Notch activation promotes tumor growth in a subset of SCC cells. The roles of Notch in the pathogenesis of esophageal squamous
Autor:
Vinesh Anandarajan, Koji Tanaka, Manabu Muto, Chiaki Noguchi, Jasmine D. Peake, Tsutomu Chiba, Yusuke Amanuma, Hiroshi Nakagawa, Shinya Ohashi, Eishi Noguchi, Grant Grothusen, Kelly A. Whelan
Publikováno v:
Gastroenterology. 148:S-79
no statistically significant difference among different cell lines. We also treat CP-A Barrett's cell line with acid (pH 6.5) for 24 hours and measured NOTCH signaling molecules by PCR array. We found that acid treatment significantly decreased NOTCH
Autor:
Yusuke Amanuma, Hiroshi Nakagawa, Osamu Kikuchi, Tomonari Matsuda, Manabu Muto, Shinya Ohashi, Tsutomu Chiba, Koji Tanaka, Shin'ichi Miyamoto, Kelly A. Whelan, Yukie Nakai
Publikováno v:
Gastroenterology. 148:S-79
no statistically significant difference among different cell lines. We also treat CP-A Barrett's cell line with acid (pH 6.5) for 24 hours and measured NOTCH signaling molecules by PCR array. We found that acid treatment significantly decreased NOTCH
Autor:
Anil K. Rustgi, Mitsuteru Natsuizaka, Kelly A. Whelan, Shingo Kagawa, Shunsuke Ohnishi, Hiroshi Nakagawa, Shinya Ohashi, Goki Suda, Naoya Sakamoto
Publikováno v:
Cancer Research. 75:A74-A74
There exists a highly tumorigenic subset of esophageal squamous cell carcinoma (ESCC) cells defined by high expression of CD44 (CD44H). CD44H cells have cancer stem-like characteristics and as few as ten CD44H cells can form tumors in an athymic nude
Autor:
Mitsuteru Natsuizaka, Harry Subramanian, Sanders Chang, Phyllis A. Gimotty, Kei Nakagawa, Andres J. Klein-Szanto, Meenhard Herlyn, Hiroshi Nakagawa, Hideaki Kinugasa, J. Alan Diehl, Anil K. Rustgi, Shingo Kagawa, Kelly A. Whelan, Shinya Ohashi
Publikováno v:
Gastroenterology. 144:S-124
Introduction:Notch1-mediated signaling influences cell fate decisions, cell cycle and carcinogenesis via a transcription activation complex consisting of ICN1 (the activated form of Notch1), the co-activatorMAML and the transcription factor CSL. Howe
Autor:
Hiroshi Nakagawa, Kelly A. Whelan, Shinya Ohashi, Andres J. Klein-Szanto, Seiji Naganuma, Mitsuteru Natsuizaka, J. Alan Diehl, Shingo Kagawa, Meenhard Herlyn, Andrew D. Rhim, Sanders Chang
Publikováno v:
Gastroenterology. 142:S-59
Background: Esophageal adenocarcinoma (EA) is often considered to arise from a clonal stem like population of cells, potentially responsible for its poor prognosis. TGF-β and Notch signaling pathways play important roles in regulating self-renewal o
Autor:
Meenhard Herlyn, Sanders Chang, Yizeng Yang, Kelly A. Whelan, Maria E. Vega, Phyllis A. Gimotty, Gabrielle S. Wong, J. Alan Diehl, Mitsuteru Natsuizaka, Shingo Kagawa, Hiroshi Nakagawa, Seiji Naganuma, Shinya Ohashi
Publikováno v:
Gastroenterology. 142:S-59
Background: Esophageal adenocarcinoma (EA) is often considered to arise from a clonal stem like population of cells, potentially responsible for its poor prognosis. TGF-β and Notch signaling pathways play important roles in regulating self-renewal o