Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Zhu, Meng"'
Publikováno v:
ETSU Faculty Works.
Phox2a and Phox2b are two homeodomain proteins that control the differentiation of noradrenergic neurons during embryogenesis. In the present study, we examined the possible effect of Phox2a/2b on the in vitro expression of the norepinephrine transpo
Externí odkaz:
https://dc.etsu.edu/etsu-works/17058
Publikováno v:
ETSU Faculty Works.
Glucocorticoids affect cellular and molecular events in brains by modulating the expression of many genes during stress. In the present study, we examined the regulatory effect of corticosterone on the expression and function of the norepinephrine tr
Externí odkaz:
https://dc.etsu.edu/etsu-works/16716
Publikováno v:
ETSU Faculty Works.
Previously, we have found glucocorticoids up-regulate norepinephrine (NE) transporter (NET) expression in vitro. However, the underlying transcriptional mechanism is poorly understood. In this study, the role of glucocorticoids on the transcriptional
Externí odkaz:
https://dc.etsu.edu/etsu-works/16360
Publikováno v:
ETSU Faculty Works.
Stress has been reported to activate the locus coeruleus (LC)-noradrenergic system. However, the molecular link between chronic stress and noradrenergic neurons remains to be elucidated. In the present study adult Fischer 344 rats were subjected to a
Externí odkaz:
https://dc.etsu.edu/etsu-works/16075
Publikováno v:
ETSU Faculty Works.
Dopamine β-hydroxylase (DBH) and norepinephrine (NE) transporter (NET) are the noradrenergic phenotypes for their functional importance to noradrenergic neurons. It is known that in vivo N-(2-chloroethyl)-N-ethyl-2- bromobenzylamine (DSP4) treatment
Externí odkaz:
https://dc.etsu.edu/etsu-works/15724
Publikováno v:
ETSU Faculty Works.
Corticotropin releasing factor (CRF) has been implicated to act as a neurotransmitter or modulator in central nervous activation during stress. In this study, we examined the regulatory effect of CRF on the expression and function of the norepinephri
Externí odkaz:
https://dc.etsu.edu/etsu-works/15384
Publikováno v:
ETSU Faculty Works.
MicroRNAs are short non-coding RNAs that provide global regulation of gene expression at the post-transcriptional level. Such regulation has been found to play a role in stress-induced epigenetic responses in the brain. The norepinephrine transporter
Externí odkaz:
https://dc.etsu.edu/etsu-works/15140
Publikováno v:
ETSU Faculty Works.
Degeneration of the noradrenergic locus coeruleus (LC) in aging and neurodegenerative diseases is well documented. Slowing or reversing this effect may have therapeutic implications. Phox2a and Phox2b are homeodomain transcriptional factors that func
Publikováno v:
ETSU Faculty Works.
Treatment of rats with reserpine, an inhibitor of the vesicular monoamine transporter (VMAT), depletes norepinephrine (NE) and regulates NE transporter (NET) expression. The present study examined the molecular mechanisms involved in regulation of th
Publikováno v:
ETSU Faculty Works.
Rationale Many studies demonstrate down-regulation of the norepinephrine transporter (NET) by desipramine (DMI) in vitro and in stress-naive rats. Little is known regarding regulation of the NET in stressed animals. Objective The present study was de
Externí odkaz:
https://dc.etsu.edu/etsu-works/8597