Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Manal F. Abdelmalek"'
Autor:
Sven M F; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Drie Eikenstraat 655, B-2650 Edegem, 2610 Wilrijk, Belgium; Laboratory of Experimental Medicine and Paediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium. Electronic address: Sven.Francque@uza.be., Pierre B; Liverpat, 28 rue de l'Amiral Hamelin, 75116 Paris, France.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, Upon Tyne, UK., Manal F A; Division of Gastroenterology and Hepatology, Duke University, 40 Duke Medicine Circle, Durham, NC 27710, USA., Quentin M A; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, Upon Tyne, UK; Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne, UK; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Elisabetta B; Division of Gastroenterology and Hepatology, Department of Medical Sciences, University of Torino, A.O. Città della Salute e della Scienza di Torino, Corso Bramante, 88 I-10126 Torino, Italy., Vlad R; AP-HP Hopital Pitié-Salpetrière, 47 Boulevard de L'Hôpital, 75013 Paris, France., Philippe HM; INVENTIVA S.A., 50 rue de DIJON, 21121 Daix, France., Bruno S; Bruno Scherrer Conseil S.A.R.L., 15 rue Beethoven, 78730 Saint Arnoult en Yvelines, France., Jean-Louis J; INVENTIVA S.A., 50 rue de DIJON, 21121 Daix, France., Pierre B; INVENTIVA S.A., 50 rue de DIJON, 21121 Daix, France., Jean-Louis A; INVENTIVA S.A., 50 rue de DIJON, 21121 Daix, France.
Publikováno v:
Contemporary clinical trials [Contemp Clin Trials] 2020 Nov; Vol. 98, pp. 106170. Date of Electronic Publication: 2020 Oct 08.
Autor:
Cynthia A. Moylan, Alisha M. Mavis, Dereje Jima, Rachel Maguire, Mustafa Bashir, Jeongeun Hyun, Melanie N. Cabezas, Alice Parish, Donna Niedzwiecki, Anna Mae Diehl, Susan K. Murphy, Manal F. Abdelmalek, Cathrine Hoyo
Publikováno v:
Epigenetics, Vol 17, Iss 11, Pp 1446-1461 (2022)
Non-Alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. Epigenetic alterations, such as through DNA methylation (DNAm), may link adverse childhood exposures and fatty liver and provide non-invasive methods
Externí odkaz:
https://doaj.org/article/340dddde15ac419da0f5f9f960cb993c
Autor:
Mary E. Rinella, Brent A. Neuschwander-Tetri, Mohammad Shadab Siddiqui, Manal F. Abdelmalek, Stephen Caldwell, Diana Barb, David E. Kleiner, Rohit Loomba
Publikováno v:
Hepatology (Baltimore, Md.), vol 77, iss 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fcbc694dffb3cda6c4da05630b6411
https://escholarship.org/uc/item/9cn5c5jr
https://escholarship.org/uc/item/9cn5c5jr
Autor:
Eric Lawitz, Manuel Romero-Gómez, Quentin M. Anstee, Stephen A. Harrison, Catherine Jia, Zobair M. Younossi, Chuhan Chung, Zachary Goodman, Robert P. Myers, Ryan S Huss, Michael Trauner, Vincent Wai-Sun Wong, Andrew J. Muir, Takeshi Okanoue, Jaime Bosch, D. Ding, Nezam H. Afdhal, Manal F. Abdelmalek, Ling Han, Arun J. Sanyal
Publikováno v:
Sanyal, Arun J; Anstee, Quentin M; Trauner, Michael; Lawitz, Eric J; Abdelmalek, Manal F; Ding, Dora; Han, Ling; Jia, Catherine; Huss, Ryan S; Chung, Chuhan; Wong, Vincent Wai-Sun; Okanoue, Takeshi; Romero-Gomez, Manuel; Muir, Andrew J; Afdhal, Nezam H; Bosch, Jaime; Goodman, Zachary; Harrison, Stephen A; Younossi, Zobair M and Myers, Robert P (2022). Cirrhosis Regression is Associated with Improved Clinical Outcomes in Patients with Nonalcoholic Steatohepatitis. Hepatology, 75(5), pp. 1235-1246. Wiley 10.1002/hep.32204
[Background and Aims] Surrogate endpoints that predict complications are necessary for assessment and approval of NASH therapies. We assessed associations between histologic and noninvasive tests (NITs) of fibrosis with liver‐related complications
Autor:
Don C. Rockey, Andrew H. Beck, Murray B. Resnick, Nezam H. Afdhal, Michael Christopher Montalto, Oscar Carrasco-Zevallos, Catherine Jia, Zachary Goodman, Harsha Pokkalla, Mitchell L. Shiffman, Zahil Shanis, Ling Han, Jaime Bosch, Manal F. Abdelmalek, Arun J. Sanyal, Quang Huy Le, Chuhan Chung, Robert P. Myers, Ilan Wapinski, Stephen A. Harrison, Dinkar Juyal
Publikováno v:
Bosch, Jaime; Chung, Chuhan; Carrasco-Zevallos, Oscar M; Harrison, Stephen A; Abdelmalek, Manal F; Shiffman, Mitchell L; Rockey, Don C; Shanis, Zahil; Juyal, Dinkar; Pokkalla, Harsha; Le, Quang Huy; Resnick, Murray; Montalto, Michael; Beck, Andrew H; Wapinski, Ilan; Han, Ling; Jia, Catherine; Goodman, Zachary; Afdhal, Nezam; Myers, Robert P; ... (2021). A Machine Learning Approach to Liver Histological Evaluation Predicts Clinically Significant Portal Hypertension in NASH Cirrhosis. Hepatology, 74(6), pp. 3146-3160. Wiley 10.1002/hep.32087
BACKGROUND AND AIMS The hepatic venous pressure gradient (HVPG) is the standard for estimating portal pressure but requires expertise for interpretation. We hypothesized that HVPG could be extrapolated from liver histology using a machine learning (M
Autor:
Manal F. Abdelmalek, Jeongeun Hyun, Steven R. Patierno, Rebecca Caffrey, Cynthia A. Moylan, Muthana Al Abo, Anna Mae Diehl, Xiyou Zhou, Seh-Hoon Oh, Arun J. Sanyal, Kun Xiang, Rajesh Kumar Dutta, Raquel Maeso-Díaz, Jennifer A. Freedman
Publikováno v:
J Hepatol
Background & Aims Non-alcoholic fatty liver disease (NAFLD), the hepatic correlate of the metabolic syndrome, is a major risk factor for hepatobiliary cancer (HBC). Although chronic inflammation is thought to be the root cause of all these diseases,
Autor:
Alisha Mavis, Kara Wegermann, Ayako Suzuki, Cynthia A. Moylan, Anna Mae Diehl, Manal F. Abdelmalek
Publikováno v:
Hepatology. 73:1199-1206
Autor:
Andrew M. Shearer, Yanling Wang, Elizabeth K. Fletcher, Rajashree Rana, Emily S. Michael, Nga Nguyen, Manal F. Abdelmalek, Lidija Covic, Athan Kuliopulos
Publikováno v:
Hepatology (Baltimore, Md.). 76(6)
Insulin resistance and poor glycemic control are key drivers of the development of NAFLD and have recently been shown to be associated with fibrosis progression in NASH. However, the underlying mechanisms involving dysfunctional glucose metabolism an
Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD
Autor:
Jiayin Zheng, Anna Mae Diehl, Cynthia D. Guy, Ayako Suzuki, Kara Wegermann, Allison E. Ashley-Koch, Shein-Chung Chow, Andrea D. Coviello, Melanie E. Garrett, Cynthia A. Moylan, Manal F. Abdelmalek
Publikováno v:
Hepatology Communications, Vol 5, Iss 4, Pp 598-607 (2021)
Hepatology Communications
Hepatology Communications
The development of fibrosis in nonalcoholic fatty liver disease (NAFLD) is influenced by genetics, sex, and menopausal status, but whether genetic susceptibility to fibrosis is influenced by sex and reproductive status is unclear. Our aim was to iden
Autor:
Sven Francque, Manal F. Abdelmalek, Veronica Miller, Claudia Filozof, Elmer Schabel, Katherine Barradas, Mazen Noureddin, Mark Berner-Hansen, Jörn M. Schattenberg, Stephanie O Omokaro, Oliver Glass
Publikováno v:
Journal of hepatology
Lifestyle modification is the foundation of treatment recommendations for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). The design of clinical trials in NASH may be impeded by the lack of a systematic approach to