Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Dan Xu"'
Autor:
Yunge Lou, Rui Wang, Na Yang, Jiye Aa, Haokai Zhao, Guangji Wang, Dan Xu, Yuan Xie, Yirui Zhang, Ran Zhang
Publikováno v:
Drug Metabolism and Disposition. 49:770-779
Silybin is widely used as a hepatoprotective agent in various liver disease therapies and has been previously identified as a CYP3A inhibitor. However, little is known about the effect of silybin on CYP3A and the regulatory mechanism during high-fat-
Publikováno v:
Journal of Neuroimmune Pharmacology. 16:835-853
Increasing studies showed that several anti-platelet drugs turned out to be a promising strategy for inflammatory response. In this study, we investigated the protective efficiency of pretreatment of indobufen or aspirin combined with clopidogrel or
Publikováno v:
International Immunopharmacology. 70:180-186
Sophocarpine (SOP) is a tetracyclic quinolizidine alkaloid isolated from Sophora alopecuroides L. A number of studies have shown that SOP has anti-inflammatory actions and protects against a variety of tissue and organ injuries. The purpose of this s
Mitoquinone ameliorates cigarette smoke-induced airway inflammation and mucus hypersecretion in mice
Publikováno v:
International immunopharmacology. 90
Background Cigarette smoking, which induces airway inflammation and mucus hypersecretion, is a major risk factor for the development of cigarette smoke (CS)-induced airway disorders. In this study, we investigated the effects and mechanisms of mitoqu
Publikováno v:
Microbial pathogenesis. 137
The anti-inflammatory property of polydatin, a natural active ingredient found in the rhizome of Polygonum cuspidatum, has been verified. Although a variety of physiological functions have been uncovered, the protective effects and mechanism of polyd
Publikováno v:
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 28(11)
Purpose: The present study was to observe the therapeutic efficiency of Clematichinenoside (AR) on cerebral ischemic injury in rats, especially on neurological and motor function recovery and to explore the underlying mechanism. Methods: Following mi
Publikováno v:
Journal of Glaucoma. 24:635-641
Purpose Long-term topical antiglaucoma therapy is considered a significant risk factor for failure of trabeculectomy. We investigated the effects of antiglaucoma drugs on proinflammatory cytokine and chemokine release from cultured human Tenon's caps
Autor:
Yi Nan Wang, Feng Guang Gao, Nan Nan Lu, Dan Dan Xu, Yue Hua Zhang, Shi Zhong Ke, Hua Xiu Sui
Publikováno v:
International journal of oncology. 51(3)
Cholinergic anti-inflammatory pathway has therapeutic effect on inflammation-associated diseases. However, the exact mechanism of nicotine-mediated anti-inflammatory effect is still unclear. TIPE2, a new member of tumor necrosis factor-α-induced pro
Autor:
Dan Han, Yunman Li, Jie Wei, Nian Xia, Dan Xu, Dongcheng Cai, Chen Shen, Yidong Feng, Rui Zhang, Weirong Fang, Wenhuan Ma
Publikováno v:
Scientific Reports
Hyperlipidemia aggravates myocardial ischemia/reperfusion (MI/R) injury through stimulating excessive inflammatory response. Therefore, blockade of inflammatory signal is a potential therapeutic management for MI/R complicated with hyperlipidemia. Hy
Autor:
Dingyu Xu, Fengyu Huang, Hu Zhou, Ziwen Chen, Dan Xu, Xiao-kun Zhang, Yuzhou Bao, Shangjie Guo, Ying Su, Xindao Zhang, Zhiping Zeng
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(16)
Previously we identified the first retinoid X receptor-alpha (RXRα) modulators that regulate the RXRα biological function via binding to the coregulator-binding site. Here we report the characterization of the interactions between the hit molecule