Zobrazeno 1 - 10
of 25
pro vyhledávání: '"James Travis"'
Publikováno v:
Biochemical and Biophysical Research Communications. 294:423-428
Stimulated neutrophils produced vascular permeability enhancing (VPE) activity in the presence of high molecular weight kininogen (HMWK), which was inhibited mainly by a neutrophil elastase (NE) inhibitor or a bradykinin (BK) B(2)-receptor antagonist
Publikováno v:
FEBS Letters. 440:282-286
Gingipains are the major cysteine proteinases synthesized by Porphyromonas gingivalis which, in soluble form, are able to initially convert IL-8 (77 amino acid residues) to a more potent species truncated at the amino terminus, followed by slow degra
Publikováno v:
Biochemical Journal. 300:401-406
In order better to understand the pathophysiology of the equine form of emphysema, two elastinolytic enzymes from horse neutrophils, referred to as proteinases 2A and 2B, have been extensively characterized and compared with the human neutrophil prot
Autor:
Neelesh Bangalore, James Travis
Publikováno v:
Biological Chemistry Hoppe-Seyler. 375:659-666
Stimulation of human neutrophils with micromolar concentrations of N-formyl-methionyl-leucyl-phenyl-alanine (fMLP) or 4 beta-phorbol-12 beta-myristate-13 alpha-acetate (PMA), results in their degranulation and/or lysis with a concomitant release of H
Publikováno v:
Journal of Biological Chemistry. 266:21482-21487
The effect of several microbial and mammalian proteinases on the inhibitory activity of human plasma alpha-1-anti-chymotrypsin (alpha-1-Achy) has been tested. Most of these enzymes caused rapid inactivation of the inhibitor by cleavage at single site
Publikováno v:
Analytical biochemistry. 260(2)
The need for a quick, simple screening method for the detection of general proteolytic activity prompted us to determine whether cleavage within the reactive site loop region (RSL) of alpha1-proteinase inhibitor (alpha1-PI), a well-characterized memb
Publikováno v:
Infection and immunity. 64(6)
The anaerobic bacterium Porphyromonas gingivalis has been implicated as a primary causative agent in adult periodontitis. Several proteinases are produced by this bacterium, and it is suggested that they contribute to virulence and to local tissue in
Publikováno v:
Scopus-Elsevier
Pulmonary emphysema and periodontal disease are each characterized by the uncontrolled proteolysis of connective tissue proteins by proteinases derived from human neutrophils. Although these diseases would not appear to be related in terms of the ini
Autor:
Hans Fritz, James Travis
Publikováno v:
The American review of respiratory disease. 143(6)
Publikováno v:
The Journal of Parasitology. 77:775
The role of human neutrophil cathepsin G (Cat G) on Eimeria tenella sporozoites was studied in vitro. Sporozoites were incubated for 2 hr at 37 C in PO4 buffer, 0.9% NaCl (PBS), pH 7.6 in the presence of Cat G (50 micrograms/ml), diisopropyl fluoroph