Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Thomas C. Foster"'
Publikováno v:
Aging (Albany NY)
We examined the contribution of N-methyl-D-aspartate receptor (NMDAR) subunits in the redox-mediated decline in NMDAR function during aging. GluN2A and GluN2B selective antagonists decreased peak NMDAR currents to a similar extent in young and aged a
Autor:
Ashok Kumar, Thomas C. Foster
Publikováno v:
Neurochemical Research. 44:38-48
Glutamate is the primary excitatory neurotransmitter in neurons and glia. N-methyl-D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainate receptors are major ionotropic glutamate receptors. Glutamatergic neurotr
Publikováno v:
Antioxidants & Redox Signaling. 28:1724-1745
Oxidative stress increases in the brain with aging and neurodegenerative diseases. Previous work emphasized irreversible oxidative damage in relation to cognitive impairment. This research has evolved to consider a continuum of alterations, from redo
Publikováno v:
Behavioural Brain Research. 322:223-232
Increased human longevity has magnified the negative impact that aging can have on cognitive integrity of older individuals experiencing some decline in cognitive function. Approximately 30% of the elderly will have cognitive problems that influence
Publikováno v:
Hippocampus. 25:1556-1566
Estradiol rapidly modulates hippocampal synaptic plasticity and synaptic transmission; however, the contribution of the various estrogen receptors to rapid changes in synaptic function is unclear. This study examined the effect of estrogen receptor s
Publikováno v:
The Journal of Neuroscience. 35:3966-3977
Young (3–6 months) and middle-age (10–14 months) rats were trained on the five-choice serial reaction time task. Attention and executive function deficits were apparent in middle-age animals observed as a decrease in choice accuracy, increase in
Autor:
Ashok Kumar, Thomas C. Foster
Publikováno v:
The Journal of Neuroscience. 33:15710-15715
NMDA receptors (NMDARs) play a critical role in learning and memory; however, there is a lack of evidence for a direct relationship between a well characterized decline in NMDAR function and impaired cognition during aging. The present study was desi
Autor:
Ling Jin, Brenna L Brim, N.M. Ellinwood, R. Haskell, Kathy R. Magnusson, Arvind Kumar, Thomas C. Foster, R. Awedikian
Publikováno v:
Behavioural Brain Research. 238:211-226
The GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor shows age-related declines in expression across the frontal cortex and hippocampus. This decline is strongly correlated to age-related memory declines. This study was designed to determin
Autor:
Thomas C. Foster
Publikováno v:
Frontiers in Neuroendocrinology. 26:51-64
Estrogen treatment during middle-age postpones memory impairments, which depend on the hippocampus. However, estrogen responsiveness diminishes with advanced age. The challenge remains to determine, which processes are important for delaying brain ag
Publikováno v:
Neuroscience. 113:89-97
Estradiol influences Ca(2+) regulation and Ca(2+)-dependent synaptic plasticity, suggesting estrogenic effects on Ca(2+)-dependent enzymes that regulate synaptic plasticity may mediate hormonal influences on cognition. In ovariectomized female rats,