Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Thomas C. Foster"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
There are sex differences in vulnerability and resilience to the stressors of aging and subsequent age-related cognitive decline. Cellular senescence occurs as a response to damaging or stress-inducing stimuli. The response includes a state of irreve
Externí odkaz:
https://doaj.org/article/b105104a5d394f09ab5acc7231aa9874
Autor:
Jessica A. Peterson, Joshua A. Crow, Alisa J. Johnson, Lingsong Meng, Asha Rani, Zhiguang Huo, Thomas C. Foster, Roger B. Fillingim, Yenisel Cruz-Almeida
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionChronic pain is one of the leading causes of disability that may accelerate biological aging and reduce physical function. Epigenetic clocks provide an estimate of how the system ages and can predict health outcomes such as physical funct
Externí odkaz:
https://doaj.org/article/d3818217c6ef44e7834a626ca2d40dc7
Autor:
Soamy Montesino-Goicolea, Lingsong Meng, Asha Rani, Zhiguang Huo, Thomas C. Foster, Roger B. Fillingim, Yenisel Cruz-Almeida
Publikováno v:
Neurobiology of Pain, Vol 12, Iss , Pp 100107- (2022)
Our study aimed to identify differentially methylated regions (i.e., genomic region where multiple adjacent CpG sites show differential methylation) and their enriched genomic pathways associated with knee osteoarthritis pain (KOA). We recruited cogn
Externí odkaz:
https://doaj.org/article/38703b23431746f489939e172fec646e
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Aging is the most prominent risk factor for cognitive decline, yet behavioral symptomology and underlying neurobiology can vary between individuals. Certain individuals exhibit significant age-related cognitive impairments, while others maintain inta
Externí odkaz:
https://doaj.org/article/c7eca479fd6a49009691e455c0587e92
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
There is a critical window for estrogen replacement therapy, beyond which estradiol (E2) fails to enhance cognition and N-methyl-D-aspartate (NMDA) receptor function, and E2-responsive transcription decreases. Much less attention has been given to th
Externí odkaz:
https://doaj.org/article/dd9c3740a3e94e0db14a852d811ea1d4
Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies
Autor:
Joseph A. McQuail, Amy R. Dunn, Yaakov Stern, Carol A. Barnes, Gerd Kempermann, Peter R. Rapp, Catherine C. Kaczorowski, Thomas C. Foster
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2021)
The goal of this review article is to provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and function throughout life. We propose that forth
Externí odkaz:
https://doaj.org/article/36f44c766a3f4b158589d4ac6f731c19
Autor:
Marcelo Febo, Asha Rani, Brittney Yegla, Jolie Barter, Ashok Kumar, Christopher A. Wolff, Karyn Esser, Thomas C. Foster
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
The current longitudinal study examined factors (sex, physical function, response to novelty, ability to adapt to a shift in light/dark cycle, brain connectivity), which might predict the emergence of impaired memory during aging. Male and female Fis
Externí odkaz:
https://doaj.org/article/2f5e49f825f34b04a82dcb34b4c4cb43
Autor:
Lara Ianov, Matt De Both, Monica K. Chawla, Asha Rani, Andrew J. Kennedy, Ignazio Piras, Jeremy J. Day, Ashley Siniard, Ashok Kumar, J. David Sweatt, Carol A. Barnes, Matthew J. Huentelman, Thomas C. Foster
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
The current study employed next-generation RNA sequencing to examine gene expression differences related to brain aging, cognitive decline, and hippocampal subfields. Young and aged rats were trained on a spatial episodic memory task. Hippocampal reg
Externí odkaz:
https://doaj.org/article/7f174db43057465d9cea4d44290dcdc8
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Community dwelling older individuals from the North Florida region were examined for health status and a comprehensive neuropsychological battery, including the Montreal Cognitive Assessment (MoCA), was performed on each participant. A subpopulation
Externí odkaz:
https://doaj.org/article/945d39f7db73458d8640a50f8dc546ab
Autor:
James A. McGuiness, Rachel B. Scheinert, Aditya Asokan, Vivien-Charlott Stadler, Christian S. Lee, Asha Rani, Ashok Kumar, Thomas C. Foster, Brandi K. Ormerod
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
We tested whether indomethacin or rosiglitazone treatment could rejuvenate spatial ability and hippocampal neurogenesis in aging rats. Young (4 mo; n = 30), middle-aged (12 mo; n = 31), and aged (18 mo; n = 31) male Fischer 344 rats were trained and
Externí odkaz:
https://doaj.org/article/e559d91a5d3842d8b13d64e439421ced