Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Christoph Kellendonk"'
Autor:
Joseph M. Villarin, Eric Teboul, Peter D. Balsam, Christoph Kellendonk, Jonathan A. Javitch, Julia E. Greenwald, Kelly M. Martyniuk, Eduardo F. Gallo, Yulong Li, Jenna Yeisley
Publikováno v:
Molecular Psychiatry. 27:1502-1514
Cholinergic interneurons (CINs) in the striatum respond to salient stimuli with a multiphasic response, including a pause, in neuronal activity. Slice-physiology experiments have shown the importance of dopamine D2 receptors (D2Rs) in regulating CIN
Autor:
Eduardo F. Gallo, Peter D. Balsam, Eleanor H. Simpson, Jonathan A. Javitch, Christoph Kellendonk
Publikováno v:
Mol Psychiatry
It was first posited, more than five decades ago, that the etiology of schizophrenia involves overstimulation of dopamine receptors. Since then, advanced clinical research methods, including brain imaging, have refined our understanding of the relati
Publikováno v:
Behav Neurosci
Ventral striatal dopamine is thought to be important for associative learning. Dopamine exerts its role via activation of dopamine D1 and D2 receptors in the ventral striatum. Upregulation of dopamine D2R in ventral striatopallidal neurons impairs in
Autor:
Sarah E. Canetta, Emma S. Holt, Laura J. Benoit, Eric Teboul, Gabriella M. Sahyoun, R. Todd Ogden, Alexander Z. Harris, Christoph Kellendonk
Publikováno v:
eLife. 11
SummaryIn their seminal findings, Hubel and Wiesel identified sensitive periods in which experience can exert lasting effects on adult visual cortical functioning and behavior via transient changes in neuronal activity during development. Whether com
Autor:
Chia-Yuan Chang, Daniel C. Lowes, Alan J. Park, Joshua A. Gordon, Atheir I. Abbas, Christoph Kellendonk, Alexander Z. Harris, Kelly M. Martyniuk, Joseph A. Gogos
Publikováno v:
Nature. 591:615-619
The ability to rapidly adapt to novel situations is essential for survival, and this flexibility is impaired in many neuropsychiatric disorders1. Thus, understanding whether and how novelty prepares, or primes, brain circuitry to facilitate cognitive
Publikováno v:
Biotechniques
The increasing interest in manipulating neural circuits in developing brains has created a demand for reliable and accurate methods for delivering viruses to newborn mice. Here we describe a novel 3D-printed mouse neonatal stereotaxic adaptor for int
Autor:
Yan Sun, Kevin A. Strauss, Raju Tomer, Bin Xu, Christoph Kellendonk, Sander Markx, Bianca Migliori, Job O. de Jong, Steven A. Kushner, Francesco Gavino Brundu, Giuseppe P. Cortese, Ceyda Llapashtica, Matthieu Genestine, Jonathan A. Javitch, Huixiang Zhu, Frank A. Provenzano, Barbara Corneo, Karlla W. Brigatti
Publikováno v:
Nature Communications, 12(1):4087. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
We utilized forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form of Autism Spectrum Disorder (ASD) with a homozygous protein-truncating mutation in CNTNAP2, to study its effects on embryonic cortical dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec795b51cca40bc7491b4e4ecfd28d92
https://pure.eur.nl/en/publications/30757659-7b90-4a4d-9440-a5a4a7c035ab
https://pure.eur.nl/en/publications/30757659-7b90-4a4d-9440-a5a4a7c035ab
Autor:
Laura J. Benoit, Emma S. Holt, Lorenzo Posani, Stefano Fusi, Alexander Z. Harris, Sarah Canetta, Christoph Kellendonk
Impaired cortical maturation is a postulated mechanism in the etiology of neurodevelopmental disorders, including schizophrenia. In sensory cortex, activity relayed by the thalamus during a postnatal sensitive period is essential for proper cortical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6458e2b65acffe4f6f4562f8d7d1d32
https://doi.org/10.21203/rs.3.rs-730508/v1
https://doi.org/10.21203/rs.3.rs-730508/v1
Autor:
Sarah Canetta, Christoph Kellendonk
Publikováno v:
Cell. 178:1282-1284
Can we one day prevent mental disorders? Mukherjee et al. (2019) use a genetic mouse model of schizophrenia-risk with established abnormalities in adult hippocampal-prefrontal circuit function and cognitive behaviors to identify circuit-specific trea
Autor:
Neil L. Harrison, Joshua A. Gordon, Christoph Kellendonk, Sarah Canetta, Emma S Holt, Nancy Padilla-Coreano, Scott S. Bolkan, Eric Teboul
Publikováno v:
Cerebral Cortex Communications
The medial prefrontal cortex (mPFC) integrates inputs from multiple subcortical regions including the mediodorsal nucleus of the thalamus (MD) and the ventral hippocampus (vHPC). How the mPFC differentially processes these inputs is not known. One po