Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Olga Garaschuk"'
Autor:
Nithi Asavapanumas, Michael T. Heneka, Nima Mojtahedi, Olga Garaschuk, Karin Odoj, Bianca Brawek
Publikováno v:
Brain, behavior and immunity 96, 113-126 (2021). doi:10.1016/j.bbi.2021.05.021
Peripheral inflammation is known to impact brain function, resulting in lethargy, loss of appetite and impaired cognitive abilities. However, the channels for information transfer from the periphery to the brain, the corresponding signaling molecules
Publikováno v:
Cell calcium. 98
Endogenous neuronal activity is a hallmark of the developing brain. In rodents, a handful of such activities were described in different cortical areas but the unifying macroscopic perspective is still lacking. Here we combined large-scale in vivo Ca
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 1091, p 1091 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 1091, p 1091 (2021)
Microglia, the innate immune cells of the brain, are commonly perceived as resident macrophages of the central nervous system (CNS). This definition, however, requires further specification, as under healthy homeostatic conditions, neither morphologi
Publikováno v:
Cell Calcium. 94:102334
S100B is an EF-hand type Ca2+-binding protein of the S100 family, known to support neurogenesis and to promote the interactions between brain's nervous and immune systems. Here, we characterized the expression of S100B in the mouse olfactory bulb, a
Autor:
Bianca, Brawek, Olga, Garaschuk
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2034
Similar to many nonexcitable cells, microglia utilize intracellular Ca
Autor:
Yajie Liang, Diego Gomez-Nicola, Yury Kovalchuk, Kristoffer Riecken, Olga Garaschuk, Kaizhen Li, Boris Fehse, Anatoliy Maslyukov
Publikováno v:
Cell Research. 26:805-821
The behavior of adult-born cells can be easily monitored in cell culture or in lower model organisms, but longitudinal observation of individual mammalian adult-born cells in their native microenvironment still proves to be a challenge. Here we have
Publikováno v:
Neurobiology of disease. 121
Besides deficits in memory and cognition, impaired visual processing is common for Alzheimer's disease (AD) patients and mouse models of AD but underlying mechanisms still remain unclear. Using in vivo Ca
Autor:
Chommanad, Lerdkrai, Nithi, Asavapanumas, Bianca, Brawek, Yury, Kovalchuk, Nima, Mojtahedi, Maria, Olmedillas Del Moral, Olga, Garaschuk
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(6)
Although both patients with Alzheimer’s disease (AD) and mouse models of the disease suffer from a profound neuronal hyperactivity mediating an impairment of memory and cognition, the underlying mechanisms remain elusive. Here, we show that neurona
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1813(5):1014-1024
In the healthy adult brain microglia, the main immune-competent cells of the CNS, have a distinct (so-called resting or surveying) phenotype. Resting microglia can only be studied in vivo since any isolation of brain tissue inevitably triggers microg
Autor:
Bruno Pichler, Yury Kovalchuk, Olga Garaschuk, Arthur Konnerth, Ruxandra-Iulia Milos, Madoka Narushima, Nathalie L. Rochefort, Nima Marandi
Publikováno v:
Proceedings of the National Academy of Sciences. 106:15049-15054
Eye-opening represents a turning point in the function of the visual cortex. Before eye-opening, the visual cortex is largely devoid of sensory inputs and neuronal activities are generated intrinsically. After eye-opening, the cortex starts to integr