Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Matthew R. Sarkisian"'
Autor:
Matthew R. Sarkisian, Megan M. Le, George Ugartemendia, Lan Hoang-Minh, Tyler S. Smith, Alexander K. Parker, Jason E. Coleman, Eric W. Atkinson, Susan L. Semple-Rowland
Publikováno v:
Experimental Neurology. 282:119-127
Neonatal or early-life seizures (ELS) are often associated with life-long neurophysiological, cognitive and behavioral deficits, but the underlying mechanisms contributing to these deficits remain poorly understood. Newborn, post-migratory cortical n
Autor:
Xin Yu, Baoli Yang, Simon D'Alton, Joshua Knight, Ian M. Farnham, Rachel M. Bailey, Yong Jie Zhang, John Howard, Monica Castanedes-Casey, Matthew R. Sarkisian, Brittany Scott, Jada Lewis, Linda Rousseau, Ashley Cannon, Dennis W. Dickson, Wen-Lang Lin, Leonard Petrucelli, Michael Jurasic, Charles A. Wuertzer
Publikováno v:
Acta Neuropathologica
Ubiquitin-immunoreactive neuronal inclusions composed of TAR DNA binding protein of 43 kDa (TDP-43) are a major pathological feature of frontotemporal lobar degeneration (FTLD-TDP). In vivo studies with TDP-43 knockout mice have suggested that TDP-43
Autor:
Raddy L, Ramos, Alyssa R, Toia, Daniel M, Pasternack, Timothy P, Dotzler, Joshua A, Cuoco, Anthony W, Esposito, Megan M, Le, Alexander K, Parker, Jeffrey H, Goodman, Matthew R, Sarkisian
Publikováno v:
Neuroscience. 337
Subcortical band heterotopia (SBH) are malformations of the human cerebral cortex typically associated with epilepsy and cognitive delay/disability. Rodent models of SBH have demonstrated strong face validity as they are accompanied by both cognitive
Autor:
Joseph J. LoTurco, Xiuyin Yin, Yu Wang, Glenn D. Rosen, Lisa A. Gabel, Matthew R. Sarkisian, Sarah M. Guadiana, Albert M. Galaburda
Publikováno v:
Neuroscience. 190:398-408
The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. Here we report the first phenotypic analysis of a Dcdc2 knockout mouse. Comparisons between Dcdc2
Publikováno v:
Science. 302:1560-1563
Cells undergoing apoptosis during development are removed by phagocytes, but the underlying mechanisms of this process are not fully understood. Phagocytes lacking the phosphatidylserine receptor (PSR) were defective in removing apoptotic cells. Cons
Publikováno v:
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 21(2)
Recognition that virtually every neuronal progenitor cell and neuron in the cerebral cortex is ciliated has triggered intense interest in neuronal cilia function. Here, we review recent studies that suggest the primary cilia of cortical progenitor ce
Autor:
Gregory L. Holmes, Matthew R. Sarkisian, Pushpa Tandon, Guo-rong Zhang, Yaming Wang, John C. Neill, Zhao Liu, Linda Yu, Alfred I. Geller
Publikováno v:
Molecular Brain Research. 93:127-136
The hippocampus has a central role in specific types of learning, but there is only limited evidence identifying the requisite molecular changes in ensembles of hippocampal neurons. To investigate the role of protein kinase C (PKC) pathways in hippoc
Autor:
Joshua J. Breunig, Sarah M. Guadiana, Kirk Mykytyn, Matthew R. Sarkisian, Irina Madorsky, Daniel Daroszewski, Susan L. Semple-Rowland
The formation of primary cilia is a highly choreographed process that can be disrupted in developing neurons by overexpressing neuromodulatory G-protein-coupled receptors GPCRs or by blocking intraflagellar transport. Here, we examined the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb73c6bc365e2d4d82c745424b8be141
https://europepmc.org/articles/PMC6619186/
https://europepmc.org/articles/PMC6619186/
Publikováno v:
The Journal of comparative neurology. 520(4)
Neuronal primary cilia are not generally recognized, but they are considered to extend from most, if not all, neurons in the neocortex. However, when and how cilia develop in neurons are not known. This study used immunohistochemistry for adenylyl cy
Autor:
Sara B. Anastas, Dorit Mueller, Joshua J. Breunig, Matthew R. Sarkisian, Susan L. Semple-Rowland
Publikováno v:
Cerebral cortex (New York, N.Y. : 1991). 21(2)
Most, if not all, cortical neurons possess a single primary cilium; however, little is known about the mechanisms that control neuronal ciliogenesis. The Citron kinase-deficient (Citron-K(fh/fh)) rat, a model in which failed cytokinesis during develo