Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael R. Vasko"'
Autor:
Gary R. Strichartz, Michael R. Vasko, Saurav Shrestha, Neilia G. Gracias, Florence H. Mujenda, Alla Khodorova
Publikováno v:
The Journal of Pain. 10:702-714
Subcutaneous injection of endothelin-1 (ET-1) into the glabrous skin of the rat's hind paw is known to produce impulses in nociceptors and acute nocifensive behavioral responses, such as hind paw flinching, and to sensitize the skin to mechanical and
Publikováno v:
Pain. 113:113-122
Tumor necrosis factor alpha (TNFalpha) and interleukin 1beta (IL-1beta) are pro-inflammatory cytokines capable of altering the sensitivity of sensory neurons. Because sensitization elicited by IL-1beta and TNFalpha is blocked by inhibition of the ind
Publikováno v:
Pain. 105:133-141
Gabapentin and pregabalin are amino acid derivatives of gamma-amino butyric acid that have anticonvulsant, analgesic, and anxiolytic-like properties in animal models. The mechanisms of these effects, however, are not well understood. To ascertain whe
Publikováno v:
Pain. 88:277-285
Sensitization of sensory neurons is a critical component of hypersensitivity that occurs during chronic pain and inflammation. Questions remain, however, whether this sensitization depends on the continuous activation of signal transduction pathways
Autor:
J. David Clark, George L. Wilcox, Robert H. Spencer, Todd W. Vanderah, Uhtaek Oh, Michael R. Vasko, Aaron C. Overland, Christoph Stein
This review summarizes recent findings on peripheral mechanisms underlying the generation and inhibition of pain. The focus is on events occurring in peripheral injured tissues that lead to the sensitization and excitation of primary afferent neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b46d2738bd79ee7127733fa9e96e79
https://europepmc.org/articles/PMC2730351/
https://europepmc.org/articles/PMC2730351/
Autor:
Yan-Gang Sun, Robert W. Gereau, Zhou-Feng Chen, Neilia G. Gracias, Julie K. Drobish, Michael R. Vasko
Publikováno v:
Pain. 144(1-2)
Protein kinase signal transduction pathways play critical roles in regulating nociception. Here we show that c-kit, a tyrosine kinase receptor, is expressed in lamina I and II layer of the dorsal horn. Moreover, the superficial c-kit + fibers origina
Publikováno v:
The journal of pain. 10(7)
Intraplantar injection of endothelin-1 (ET-1) (1.5–10 μM) in the rat produces mechanical allodynia. Here we identify the receptor subtypes for ET-1, glutamate and CGRP critical to such allodynia. Antagonism of ET A or ET B receptors alone, by BQ12
Publikováno v:
PainReferences. 96(3)
Although the tissue levels of prostaglandins are elevated for a relatively long period during injury or inflammation, few studies have been performed to assess the effects of prolonged prostaglandin exposure on receptor binding and activity in sensor
Publikováno v:
Brain research. 712(2)
To determine whether the sensitizing action of prostaglandins on sensory neurons are due to modulation of voltage-sensitive calcium channels (VSCC) we examined the effects of inhibiting these channels on PGE2-induced enhancement of evoked peptide rel
Autor:
Michael R. Vasko, Cynthia M. Hingtgen
Publikováno v:
Brain research. 655(1-2)
Prostacyclin (PGI2) is a potent prostanoid producing various symptoms of inflammation, including an increased sensitivity to noxious stimulation. One component of these PGI2-mediated actions may involve activation or sensitization of sensory neurons