Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Maria Tsoli"'
Autor:
Yolanda Colino Sanguino, Laura Rodriguez de la Fuente, Dana Kisswani, Padraic Kearney, Evangeline Jackson, Ryan Duchatel, Holly Holliday, Nada Jabado, Maria Tsoli, David Ziegler, Matthew Dun, Fatima Valdes Mora
Publikováno v:
Neuro-Oncology. 24:i26-i27
Diffuse intrinsic pontine glioma (DIPG) is the most aggressive brain tumor found in children with a peak incidence of 5-7 years of age, with median survival after diagnosis less than one year. In more than 60% of DIPG cases, a recurring somatic mutat
Autor:
Jessica W Tsai, Paloma Cejas, Dayle K Wang, Smruti Patel, David W Wu, Phonepasong Arounleut, Xin Wei, Ningxuan Zhou, Sudeepa Syamala, Frank P B Dubois, Alexander Crane, Kristine Pelton, Jayne Vogelzang, Cecilia Sousa, Audrey Baguette, Xiaolong Chen, Alexandra L Condurat, Sarah E Dixon-Clarke, Kevin N Zhou, Sophie D Lu, Elizabeth M Gonzalez, Madison S Chacon, Jeromy J Digiacomo, Rushil Kumbhani, Dana Novikov, J'Ya Hunter, Maria Tsoli, David S Ziegler, Uta Dirksen, Natalie Jager, Gnana Prakash Balasubramanian, Christof M Kramm, Michaela Nathrath, Stefan Bielack, Suzanne J Baker, Jinghui Zhang, James M McFarland, Gad Getz, Francois Aguet, Nada Jabado, Olaf Witt, Stefan M Pfister, Keith L Ligon, Claudia L Kleinman, Henry Long, David T W Jones, Pratiti Bandopadhayay, Timothy N Phoenix
BACKGROUND: Understanding how aberrant transcription factors (TFs) hijack normal development to induce oncogenesis is a critical question in oncology. Forkhead box (FOX) proteins are a superfamily of transcriptional regulators characterized by a fork
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d62d7fc7e751a4d28899955a247a5d
Autor:
Dannielle Upton, Sandra George, Jie Liu, Dongpo Doug Cai, Steven Yung-Chang Su, Benjamin Rayner, Maria Tsoli, David Ziegler
Publikováno v:
Neuro-Oncology. 24:i19-i19
Diffuse Intrinsic Pontine Gliomas (DIPG) are a subset of Diffuse Midline Gliomas (DMG) and are the most devastating of all brain tumours. There are currently no effective treatments. ACT001 is a novel anti-cancer agent in clinical development that is
Autor:
Caitlin Ung, Dannielle H Upton, Pooja Venkat, Ruby Pandher, Flavio Curnis, Angelo Corti, Joesph Nicolazzo, Chelsea Mayoh, Maria Tsoli, David S Ziegler
Publikováno v:
Neuro-Oncology. 24:i22-i22
Diffuse Intrinsic Pontine Glioma (DIPG) is an aggressive paediatric high-grade glioma with no effective therapies. The blood-brain barrier (BBB) presents a significant obstacle for delivery of therapeutics into the brain, especially in the brainstem.
Autor:
Stacey Line, Babu Velayuthan Sajesh, Kelly Schwinghamer, Vinith Yathindranath, Maria Tsoli, David Ziegler, Teruna Siahaan, Donald Miller, Magimairajan Issai Vanan
Publikováno v:
Neuro-Oncology. 24:i32-i32
BACKGROUND: Diffuse midline glioma of the Pons (DMG-P) is the most common brainstem tumor of childhood and is universally fatal. The BBB is frequently intact in DIPG and restricts entry of systemically administered conventional and biological therapi
Autor:
Filip Michniewicz, Jessica Bell, Federica Saletta, Tayla Watkinson, Daniele Mercatelli, Federico M Giorgi, Christopher K Barlow, Pouya Faridi, Maria Tsoli, David Ziegler, Orazio Vittorio
Publikováno v:
Neuro-Oncology. 24:i22-i22
DIPG is an incurable pediatric brain cancer of the ventral pons characterized by its complex epigenetic profile. Up to 81% of patients present with mutation H3K27M, resulting in the global reduction of H3K27 trimethylation and increased H3K27 acetyla
Autor:
Holly Holliday, Anahid Ehteda, Aaminah Khan, Brian Krug, Jourdin R C Rouaen, Nisitha Jayatilleke, Chelsea Mayoh, Orazio Vittorio, Nada Jabado, Maria Tsoli, David S Ziegler
Publikováno v:
Neuro-Oncology. 24:i18-i18
Effective treatments are urgently needed for the incurable paediatric brainstem tumour Diffuse Midline Glioma (DMG). Most DMGs contain Histone H3 mutations (H3K27M), which produce extensive epigenetic dysregulation by inhibiting EZH2-mediated trimeth
Autor:
Cynthia Hawkins, Scott Ryall, Cecilia Chang, Jie Liu, Swapna Joshi, Yevgen Chornenkyy, Man Yu, David S. Ziegler, Maria Tsoli, Han Shen, Robert Siddaway
Publikováno v:
Neuro-Oncology
Background Despite increased understanding of the genetic events underlying pediatric high-grade gliomas (pHGGs), therapeutic progress is static, with poor understanding of nongenomic drivers. We therefore investigated the role of alterations in mito
Autor:
John Caird, Stephanie Francis, Rachid Drissi, Chris Jones, Anahid Ehteda, Maria Vinci, Cynthia Hawkins, Jordan R. Hansford, Darach Crimmins, Alexander Plessier, Dannis G. van Vuurden, Tim Hassall, Danielle Upton, Bing Liu, David Castel, Jane Pears, Jane Cryan, Michael Farrell, Louise E. Ludlow, Esther Hulleman, Diana Carvalho, Michelle Monje, Chelsea Mayoh, Michaël H. Meel, Maria Tsoli, Jacques Grill, Andrea Carai, Maryam Fouladi, Maria Kirby, David S. Ziegler, Angela Mastronuzzi, Nicholas G. Gottardo, Han Shen, Laura Franshaw
Publikováno v:
Tsoli, M, Shen, H, Mayoh, C, Franshaw, L, Ehteda, A, Upton, D, Carvalho, D, Vinci, M, Meel, M H, van Vuurden, D, Plessier, A, Castel, D, Drissi, R, Farrell, M, Cryan, J, Crimmins, D, Caird, J, Pears, J, Francis, S, Ludlow, L E A, Carai, A, Mastronuzzi, A, Liu, B, Hansford, J, Gottardo, N, Hassall, T, Kirby, M, Fouladi, M, Hawkins, C, Monje, M, Grill, J, Jones, C, Hulleman, E & Ziegler, D S 2019, ' International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma ', Journal of Neuro-Oncology, vol. 141, no. 2, pp. 253-263 . https://doi.org/10.1007/s11060-018-03038-2
Journal of Neuro-Oncology, 141(2), 253-263. Kluwer Academic Publishers
Journal of Neuro-Oncology, 141(2), 253-263. Kluwer Academic Publishers
Purpose: Diffuse intrinsic pontine glioma is the most aggressive form of high grade glioma in children with no effective therapies. There have been no improvements in survival in part due poor understanding of underlying biology, and lack of represen
Autor:
Nicole Yeung, Isabella Orienti, Anahid Ehteda, Jie Liu, Giovanna Farruggia, Han Shen, Patrick Reynolds, Sandra George, Caitlin Ung, Maria Tsoli, Laura Franshaw, Santosh Valvi, Aaminah Khan, Dannielle Upton, David S. Ziegler
Publikováno v:
Neuro-Oncology
Diffuse Intrinsic Pontine Gliomas (DIPGs) are the most devastating of all brain tumors. There are no effective treatments, hence almost all children will die of their tumor within 12-months. There is an urgent need for novel effective therapies for t