Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Bruce R. Ransom"'
Autor:
Margaret Hamner, Ashley McDonough, Cara Nielson, Davin Gong, Levi Todd, German Rojas, Thomas Reh, Bruce R Ransom, Jonathan R Weinstein
Publikováno v:
Stroke. 54
Background: Ischemic preconditioning (IPC) is a robust protective phenomenon whereby brief ischemic exposure confers protection against a subsequent prolonged ischemic challenge. IPC has been studied primarily in gray matter predominant models, howev
Autor:
Angus M. Brown, Bruce R. Ransom
Publikováno v:
Metabolic Brain Disease. 30:233-239
Energy metabolism in the brain is a complex process that is incompletely understood. Although glucose is agreed as the main energy support of the brain, the role of glucose is not clear, which has led to controversies that can be summarized as follow
Autor:
Angus M. Brown, Margaret A. Hamner, Xin Yang, Richard D. Evans, Bruce R. Ransom, Zu Cheng Ye, Sheng-Di Chen
Publikováno v:
Annals of Neurology. 75:492-507
Objective: Hypoglycemia is a common adverse event and can injure central nervous system (CNS) white matter (WM). We determined if glutamate receptors were involved in hypoglycemic WM injury. Methods: Mouse optic nerves (MON), CNS WM tracts, were main
Publikováno v:
Journal of neuroimmunology. 298
Neuromyelitis optica (NMO) is a recurrent inflammatory disease that preferentially targets the optic nerves and spinal cord. The presence of antibodies to the water channel protein aquaporin-4 (AQP4), expressed almost exclusively in astrocytes in the
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 31:996-1002
The mammalian central nervous system (CNS) is generally believed to be completely dependent on the presence of oxygen (O2) to maintain energy levels necessary for excitability. However, previous studies on CNS white matter (WM) have shown that a larg
Publikováno v:
Parkinsonism & Related Disorders. 10:47-50
Corticobasal degeneration (CBD) is a movement disorder characterized by early apraxia and asymmetric parkinsonism that responds poorly to anti-Parkinson medications. There are clinical manifestations reflecting dysfunction in both the cerebral cortex
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 21:385-395
The authors investigated ionic mechanisms underlying aglycemic axon injury in adult rat optic nerve, a central white matter tract. Axon function was assessed using evoked compound action potentials (CAPs). Glucose withdrawal led to delayed CAP failur
Publikováno v:
Molecular and Chemical Neuropathology. 27:107-129
Anoxia/ischemia in the CNS is a common and devastating phenomenon. It is possible that the best hopes for protection against anoxic/ischemic injury may involve recruiting and/or augmenting any autoprotective systems that evolution has provided for th
Publikováno v:
Cerebrovascular Diseases. 6:59-65
The incidence of stroke involving CNS white matter is relatively high, yet there are currently no protective treatments that limit irreversible dysfunction in white matter stroke. The events that lead
Publikováno v:
Brain Research. 706:210-216
It is generally known that hyperventilation produces an increase in neuronal excitability. However, the mechanism whereby a change in CO2 partial pressure (Pco2) leads to changes in neural excitability is not known. We have studied this phenomenon in