Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Achim Schmidtko"'
Autor:
Achim Schmidtko, Lea Kennel, Oliver Drees, Doris Koesling, Wiebke Kallenborn-Gerhardt, Jonas Petersen, Catherine Isabell Real, Rebecca Dorothee Steubing, Andreas Friebe, Evanthia Mergia, Ruirui Lu
Publikováno v:
Pain. 160:607-618
A large body of evidence indicates that nitric oxide (NO)/cGMP signaling essentially contributes to the processing of chronic pain. In general, NO-induced cGMP formation is catalyzed by 2 isoforms of guanylyl cyclase, NO-sensitive guanylyl cyclase 1
Autor:
Mirco Steger, Lea Kennel, Gerd Geisslinger, Ruirui Lu, Reynir Scheving, Irmgard Tegeder, Wiebke Kallenborn-Gerhardt, Aimee L. Edinger, Jonas Petersen, Jana E. Lorenz, Juliana Heidler, Christine V. Möser, Achim Schmidtko, Heinrich Heide, Cathrin Flauaus, Ilka Wittig
Publikováno v:
Pain. 158(7)
Chronic pain is accompanied by production of reactive oxygen species (ROS) in various cells that are important for nociceptive processing. Recent data indicate that ROS can trigger specific redox-dependent signaling processes, but the molecular targe
Autor:
Achim Schmidtko, Ronald Schmidt, Maria Burian, Kosta Altis, Carlo Angioni, Gerd Geisslinger, Katja Hardt, Maurizio Podda
Publikováno v:
Pain. 127:287-295
Induction of a freeze lesion in human skin is an experimental model of hyperalgesia that allows assessing the antihyperalgesic effects of traditional non-steroidal anti-inflammatory drugs (NSAIDs). We have investigated whether this model is also sens
Autor:
Peter Ruth, Irmgard Tegeder, Ellen Niederberger, Achim Schmidtko, Corina Ehnert, Domenico Del Turco, Gerd Geisslinger, Thomas Deller, Ovidiu Coste
Publikováno v:
Pain. 115:171-181
The synaptic vesicle protein synapsin II plays an important role in the regulation of neurotransmitter release and synaptic plasticity. Here, we investigated its involvement in the synaptic transmission of nociceptive signals in the spinal cord and t
Autor:
Andreas Weigert, Bernhard Brüne, Achim Schmidtko, Stephan W. Hohmann, Gerd Geisslinger, Wiebke Kallenborn-Gerhardt, Marco Sisignano, Katrin Schröder, Katharina M.J. Syhr, Ralf P. Brandes, Ruirui Lu, Jana E. Lorenz
Publikováno v:
Pain. 155(10)
Emerging lines of evidence indicate that production of reactive oxygen species (ROS) at distinct sites of the nociceptive system contributes to the processing of neuropathic pain. However, the mechanisms underlying ROS production during neuropathic p
Autor:
Achim Schmidtko, Marco Sisignano, Gerd Geisslinger, Ruirui Lu, Matthias Sausbier, Rohini Kuner, Peter Ruth, Claus-Dieter Schuh, Dong Dong Zhang, Robert Lukowski
Publikováno v:
PainReferences. 155(3)
Summary: The in vivo function of large conductance calcium‐activated potassium channels in sensory neurons includes control of inflammatory pain, but not of acute nociceptive or nerve injury‐induced neuropathic pain. ABSTRACT: Large conductance c
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 12, p e29240 (2011)
PLoS ONE, Vol 6, Iss 12, p e29240 (2011)
Accumulating evidence indicates that increased generation of reactive oxygen species (ROS) contributes to the development of exaggerated pain hypersensitivity during persistent pain. In the present study, we investigated the antinociceptive efficacy
Autor:
Gerd Geisslinger, Jörn Lötsch, Helmut Schmidt, Kosta Altis, Carlo Angioni, Achim Schmidtko, Irmgard Tegeder, Karina Kuczka
Publikováno v:
Pain. 147(1-3)
We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers. Tramadol 100mg significantly reduced ment
Publikováno v:
PainReferences. 139(3)
The synaptic vesicle protein synapsin II is specifically expressed in synaptic terminals of primary afferent nociceptive neurons and regulates transmitter release in the spinal cord dorsal horn. Here, we assessed its role in nerve injury-evoked molec
Autor:
Susanne Kunz, Corina Ehnert, Jochen Kruip, Ellen Niederberger, Thomas M Wendrich, Achim Schmidtko, Anja Pfenninger, Gerd Geisslinger, Irmgard Tegeder, Ovidiu Coste
Publikováno v:
Pain. 110(1-2)
Since long-term hyperexcitability of nociceptive neurons in the spinal cord has been suggested to be caused and maintained by changes of protein expression we assessed protein patterns in lumbar spinal cord during a zymosan induced paw inflammation e