Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jeffrey E. DeClue"'
Autor:
Giovanna Benvenuto, Nancy Ratner, Bo Ling, William C. Vass, David Viskochil, Shaowei Li, Sue C. Heffelfinger, Jeffrey E. DeClue, Wen Rui
Publikováno v:
Journal of Clinical Investigation. 105:1233-1241
We have found that EGF-R expression is associated with the development of the Schwann cell-derived tumors characteristic of neurofibromatosis type 1 (NF1) and in animal models of this disease. This is surprising, because Schwann cells normally lack E
Publikováno v:
Proceedings of the National Academy of Sciences. 90:5539-5543
The NF1 gene, which is altered in patients with type 1 neurofibromatosis, encodes neurofibromin, a protein whose GTPase-activating function can negatively regulate GTP-Ras by accelerating its conversion to inactive GDP-Ras. In schwannoma cell lines f
Autor:
Jonathan A. Fletcher, Douglas R. Lowy, Nancy Ratner, Scott R. Diehl, William C. Vass, Jeffrey E. DeClue, Alex G. Papageorge
Publikováno v:
Cell. 69:265-273
Tumor cell lines derived from malignant schwannomas removed from patients with neurofibromatosis type 1 (NF1) have been examined for the level of expression of NF1 protein. All three NF1 lines examined expressed lower levels of NF1 protein than contr
Publikováno v:
Proceedings of the National Academy of Sciences. 88:9914-9918
The neurofibromatosis type 1 (NF1) gene responsible for von Recklinghausen neurofibromatosis is related to regulators of ras proteins, and a portion of NF1 that is homologous to the ras GTPase-activating protein (GAP) encodes a similar GTPase-stimula
Autor:
A T Look, M B Valentine, Douglas R. Lowy, Berthe M. Willumsen, H. Cen, Jeffrey E. DeClue, Ke Zhang, Alex G. Papageorge, William C. Vass, M. R. Johnson
Publikováno v:
Ciba Foundation Symposium 176-The GTPase Superfamily
We are studying the biological activity and regulation of mammalian Ras protein in tumours and in physiological signalling. We have shown that GAP (the GTPase-activating protein) is a potent negative regulator of normal Ras in cells. Reduction or los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d47c0c2231f02e237c275e3c2260b9b2
https://doi.org/10.1002/9780470514450.ch5
https://doi.org/10.1002/9780470514450.ch5
Autor:
Shyra J. Miller, Tilat A. Rizvi, Gabrielle deCourten-Myers, Jianqiang Wu, Nancy Ratner, Benjamin C. Ling, Kelly R. Monk, Kristine S. Vogel, Jeffrey E. DeClue, Rania Shamekh
Publikováno v:
Cancer cell. 7(1)
Benign neurofibromas and malignant peripheral nerve sheath tumors are serious complications of neurofibromatosis type 1. The epidermal growth factor receptor is not expressed by normal Schwann cells, yet is overexpressed in subpopulations of Nf1 muta