Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Manabu, Igarashi"'
Publikováno v:
PeerJ Physical Chemistry, Vol 3, p e19 (2021)
The substitution of Ile to Val at residue 117 (I117V) of neuraminidase (NA) reduces the susceptibility of the A/H5N1 influenza virus to oseltamivir (OTV). However, the molecular mechanism by which the I117V mutation affects the intermolecular interac
Externí odkaz:
https://doaj.org/article/2ec2189464f945cbaa831c4abf17bdf6
Publikováno v:
PeerJ Physical Chemistry, Vol 3, p e19 (2021)
The substitution of Ile to Val at residue 117 (I117V) of neuraminidase (NA) reduces the susceptibility of the A/H5N1 influenza virus to oseltamivir (OTV). However, the molecular mechanism by which the I117V mutation affects the intermolecular interac
Publikováno v:
PeerJ
PeerJ, Vol 9, p e11552 (2021)
PeerJ, Vol 9, p e11552 (2021)
Background Oseltamivir (OTV)-resistant influenza virus exhibits His-to-Tyr mutation at residue 274 (H274Y) in N1 neuraminidase (NA). However, the molecular mechanisms by which the H274Y mutation in NA reduces its binding affinity to OTV have not been
Autor:
Manabu Igarashi
Publikováno v:
YAKUGAKU ZASSHI. 135:1015-1021
For the prevention and control of infectious viral diseases, vaccines and antiviral drugs targeting viral proteins are of great importance. Amino acid substitutions in viral proteins occasionally cause the emergence of antibody-escape and drug-resist
Autor:
Shinichiro Nakamura, Yasushi Itoh, Misako Nakayama, Kazumasa Ogasawara, Masatoshi Okamatsu, Michiko Doi, Masanori Shiohara, Hiroshi Kida, Yoshihiro Sakoda, Hideaki Ishida, Hirohito Ishigaki, Akihiro Ishii, Naoko Kitagawa, Hideaki Tsuchiya, Manabu Igarashi, Shintaro Shichinohe, Takako Sasamura
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:4962-4973
The number of patients infected with H7N9 influenza virus has been increasing since 2013. We examined the efficacy of neuraminidase (NA) inhibitors and the efficacy of a vaccine against an H7N9 influenza virus, A/Anhui/1/2013 (H7N9), isolated from a
Autor:
Naganori Nao, Junya Yamagishi, Hiroko Miyamoto, Manabu Igarashi, Rashid Manzoor, Aiko Ohnuma, Yoshimi Tsuda, Wakako Furuyama, Asako Shigeno, Masahiro Kajihara, Noriko Kishida, Reiko Yoshida, Ayato Takada, Mary K. Estes
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
mBio, Vol 8, Iss 1, p e02298-16 (2017)
mBio
mBio, Vol 8, Iss 1, p e02298-16 (2017)
mBio
Highly pathogenic avian influenza viruses with H5 and H7 hemagglutinin (HA) subtypes evolve from low-pathogenic precursors through the acquisition of multiple basic amino acid residues at the HA cleavage site. Although this mechanism has been observe
Autor:
Kimihito Ito, Yoshihiro Kawaoka, Ryo Takano, Masakazu Sekijima, Ayato Takada, Maki Kiso, Manabu Igarashi, Quynh Mai Le
Publikováno v:
The Journal of Infectious Diseases. 207:89-97
Background. The neuraminidase (NA) inhibitor oseltamivir is widely used to treat patients infected with influenza viruses. An Ile-to-Val change at position 117 in influenza A virus subtype H5N1 NA (NA-I117V) confers a reduction in susceptibility to o
Autor:
Hiroko Miyamoto, Manabu Igarashi, Reiko Yoshida, Ken Maeda, Junki Maruyama, Hirohito Ogawa, Ayato Takada, Naganori Nao
Publikováno v:
Virology
Recently found bat-derived influenza viruses (BatIVs) have hemagglutinin (HA) and neuraminidase (NA) gene segments distinct from those of previously known influenza A viruses. However, pathogenicities of these BatIVs remain unknown since infectious v