Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Yuji Ikegaya"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 144, Iss 4, Pp 212-217 (2020)
The hippocampus is a brain region well-known to exhibit structural and functional changes in temporal lobe epilepsy. Studies analyzing the brains of patients with epilepsy and those from animal models of epilepsy have revealed that microglia are exce
Autor:
Yuji Ikegaya, Satoshi Iwasaki
Publikováno v:
Cerebral Cortex. 31:785-794
Memory retrieval depends on reactivation of memory engram cells. Inadvertent activation of these cells is expected to cause memory-retrieval failure, but little is known about how noisy activity of memory-irrelevant neurons impacts mnemonic processes
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Dopaminergic neurons in the ventral tegmental area (VTA) play a crucial role in the processing of reward-related information. Recent studies with pharmacological manipulations of VTA neuronal activity demonstrated a VTA-induced immunoenhancement in p
Publikováno v:
Neuropsychopharmacology Reports
Background Status epilepticus‐induced hippocampal neuronal death, astrogliosis, and the activation of microglia are common pathological changes in mesial temporal lobe epilepsy (mTLE) with resistance to antiepileptic drugs. Neuronal death in mTLE g
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100572-(2021)
STAR Protocols
STAR Protocols
Summary A major challenge in neuroscience is linking synapses to cognition and behavior. Here, we developed an experimental technique to concurrently conduct a whole-cell recording of a prefrontal neuron and a multiunit recording of hippocampal neuro
Publikováno v:
Cells, Vol 10, Iss 1348, p 1348 (2021)
Cells
Cells
Phagocytosis by glial cells has been shown to play an important role in maintaining brain homeostasis. Microglia are currently considered to be the major phagocytes in the brain parenchyma, and these cells phagocytose a variety of materials, includin
Publikováno v:
Frontiers in Neuroanatomy, Vol 15 (2021)
Frontiers in Neuroanatomy
Frontiers in Neuroanatomy
Excitatory neurons and GABAergic interneurons constitute neural circuits and play important roles in information processing. In certain brain regions, such as the neocortex and the hippocampus, there are fewer interneurons than excitatory neurons. In
Publikováno v:
Physiology International.
During behavioral states of immobility, sleep, and anesthesia, the hippocampus generates high-frequency oscillations called ripples. Ripples occur simultaneously with synchronous neuronal activity in the neocortex, known as slow waves, and contribute
Publikováno v:
Journal of neurophysiology. 125(4)
Mean firing rates vary across neurons in a neuronal network. Although most neurons infrequently emit spikes, a small fraction of neurons exhibit extremely high frequencies of spikes; this fraction of neurons plays a pivotal role in information proces
Publikováno v:
Neuropsychopharmacology Reports
Aim The accumulation of amyloid beta (Aβ) is one of the characteristics of Alzheimer's disease. The excessive accumulation of Aβ has been suggested to result in a decrease in the number of synapses. Although the number of synapses is generally modu