Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Grady Phillips"'
Autor:
Gina Samuelson, Ruth M. Gill, Celia Jenkinson, Duane Delimont, Radko Komers, Jared J. Hartsock, Grady Phillips, Dominic Cosgrove, Michael Anne Gratton, James Hasson, Daniel T. Meehan, Brianna Dufek
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims In Alport syndrome (AS), endothelin type A receptor (ETAR) activation plays a role in both renal and inner ear pathologies. Currently, angiotensin converting enzyme inhibitors or angiotensin II type 1 receptor (AT1R) blockers are
Autor:
Shiguang Liu, Duane Delimont, Brianna Dufek, Michael Anne Gratton, Linda Cheung, Wenping Song, Grady Phillips, Daniel T. Meehan, Dominic Cosgrove
Publikováno v:
Kidney International. 90:300-310
Recent work demonstrates that Alport glomerular disease is mediated through a biomechanical strain-sensitive activation of mesangial actin dynamics. This occurs through a Rac1/CDC42 cross-talk mechanism that results in the invasion of the subcapillar
Autor:
Grady Phillips, Michael Anne Gratton, Duane Delimont, Deidre A. MacKenna, Gretchen Bain, Dominic Cosgrove, Daniel T. Meehan, Brianna Dufek, Michael Hartnett, Gina Samuelson
Publikováno v:
Kidney Int
Lysyl oxidase like-2 (LOXL2) is an amine oxidase with both intracellular and extracellular functions. Extracellularly, LOXL2 promotes collagen and elastin crosslinking, whereas intracellularly, LOXL2 has been reported to modify histone H3, stabilize
Autor:
Duane Delimont, Grady Phillips, Daniel T. Meehan, Dominic Cosgrove, Brianna Dufek, Marisa Zallocchi, Michael Anne Gratton
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99083 (2014)
PLoS ONE
PLoS ONE
It has been known for some time that laminins containing α1 and α2 chains, which are normally restricted to the mesangial matrix, accumulate in the glomerular basement membranes (GBM) of Alport mice, dogs, and humans. We show that laminins containi