Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Xiumei Huang"'
Autor:
Jiangwei Wang, Xiaolin Su, Lingxiang Jiang, Matthew W. Boudreau, Lindsay E. Chatkewitz, Jessica A. Kilgore, Kashif Rafiq Zahid, Noelle S. Williams, Yaomin Chen, Shaohui Liu, Paul J. Hergenrother, Xiumei Huang
Publikováno v:
Cancers, Vol 15, Iss 24, p 5844 (2023)
Lung and breast cancers rank as two of the most common and lethal tumors, accounting for a substantial number of cancer-related deaths worldwide. While the past two decades have witnessed promising progress in tumor therapy, developing targeted tumor
Externí odkaz:
https://doaj.org/article/e68fc5c06b6b49fc825f9ed81528a168
Autor:
Soumya Tumbath, Lingxiang Jiang, Xiaoguang Li, Taolan Zhang, Kashif Rafiq Zahid, Ye Zhao, Hao Zhou, Zhijun Yin, Tao Lu, Shu Jiang, Yaomin Chen, Xiang Chen, Yang-Xin Fu, Xiumei Huang
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
NAD(P)H:quinone oxidoreductase 1 (NQO1) is overexpressed in most solid cancers, emerging as a promising target for tumor-selective killing. β-Lapachone (β-Lap), an NQO1 bioactivatable drug, exhibits significant antitumor effects on NQO1-positive ca
Externí odkaz:
https://doaj.org/article/949b1bfe9fef4f57be1db5d9a66f7789
Autor:
Aishat Motolani, Matthew Martin, Benlian Wang, Guanglong Jiang, Faranak Alipourgivi, Xiumei Huang, Ahmad Safa, Yunlong Liu, Tao Lu
Publikováno v:
Cancers, Vol 15, Iss 19, p 4742 (2023)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with a mere 5-year survival of ~10%. This highlights the urgent need for innovative treatment options for PDAC patients. The nuclear factor κB (NF-κB) is a crucial tran
Externí odkaz:
https://doaj.org/article/a33f8bdcc9f94338aabaff7a7e796e6b
Autor:
Lingxiang Jiang, Yingchun Liu, Xiaolin Su, Jiangwei Wang, Ye Zhao, Soumya Tumbath, Jessica A. Kilgore, Noelle S. Williams, Yaomin Chen, Xiaolei Wang, Marc S. Mendonca, Tao Lu, Yang-Xin Fu, Xiumei Huang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have exhibited great promise in the treatment of tumors with homologous recombination (HR) deficiency, however, PARPi resistance, which ultimately recovers DNA repair and cell progress, has becom
Externí odkaz:
https://doaj.org/article/7294b000718d473d9094375b83e0e831
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Neutrophils, the most copious leukocytes in human blood, play a critical role in tumorigenesis, cancer progression, and immune suppression. Recently, neutrophils have attracted the attention of researchers, immunologists, and oncologists because of t
Externí odkaz:
https://doaj.org/article/206a74b079c647989cb2418a94bbdd52
Autor:
Wenxiu Zhao, Lingxiang Jiang, Ting Fang, Fei Fang, Yingchun Liu, Ye Zhao, Yuting You, Hao Zhou, Xiaolin Su, Jiangwei Wang, Sheng Liu, Yaomin Chen, Jun Wan, Xiumei Huang
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death globally. Currently there is a lack of tumor-selective and efficacious therapies for hepatocellular carcinoma. β-Lapachone (ARQ761 in clinical form) selectively kill
Externí odkaz:
https://doaj.org/article/b6644f8b793e46278c14dc25851e6d0e
Autor:
Colton L. Starcher, S. Louise Pay, Naveen Singh, I-Ju Yeh, Snehal B. Bhandare, Xiaolin Su, Xiumei Huang, Erik A. Bey, Edward A. Motea, David A. Boothman
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Ionizing radiation (IR) creates lethal DNA damage that can effectively kill tumor cells. However, the high dose required for a therapeutic outcome also damages healthy tissue. Thus, a therapeutic strategy with predictive biomarkers to enhance the ben
Externí odkaz:
https://doaj.org/article/a9f93e68362c453783961f81542a9d68