Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sang Hyun Song"'
Autor:
Myungshin Kim, Sang-Hyun Song, Yonggoo Kim, Changill Ban, Hayoung Choi, Sourav Mishra, Joon Won Park, Tae-You Kim, Jinseong Jeon, Jun-Kyu Kang
Publikováno v:
Nano Letters. 21:9061-9068
Cell-free DNA (cfDNA) analysis, specifically circulating tumor DNA (ctDNA) analysis, provides enormous opportunities for noninvasive early assessment of cancers. To date, PCR-based methods have led this field. However, the limited sensitivity/specifi
Autor:
Meihui Li, Xianyu Wen, Young Hoon Kim, Yun Jee Kim, Nam Yun Cho, Yun Joo Shin, Gyeong Hoon Kang, Sang Hyun Song
Publikováno v:
Gastric Cancer. 24:602-610
Gastric cancer (GC) is a leading cause of cancer morbidity and mortality worldwide. This is due to the heterogeneous features of GC, which consist of a diverse molecular phenotype. Epstein–Barr virus (EBV)-positive GC and microsatellite instability
Autor:
Yoo Joo Lim, Tae-You Kim, Sung Jin Kim, Young Won Cho, Sae-Won Han, Sang Hyun Song, Dong Wook Min, Ye Lim Park, Kyu Joo Park, Seul Ki Cheon, Hwang-Phill Kim
Publikováno v:
International Journal of Cancer. 144:389-401
PIK3CA is a frequently mutated gene in cancer, including about ~15 to 20% of colorectal cancers (CRC). PIK3CA mutations lead to activation of the PI3K/AKT/mTOR signaling pathway, which plays pivotal roles in tumorigenesis. Here, we investigated the m
Autor:
Ye-Lim, Park, Hwang-Phill, Kim, Young-Won, Cho, Dong-Wook, Min, Seul-Ki, Cheon, Yoo Joo, Lim, Sang-Hyun, Song, Sung Jin, Kim, Sae-Won, Han, Kyu Joo, Park, Tae-You, Kim
Publikováno v:
International Journal of Cancer
PIK3CA is a frequently mutated gene in cancer, including about ~15 to 20% of colorectal cancers (CRC). PIK3CA mutations lead to activation of the PI3K/AKT/mTOR signaling pathway, which plays pivotal roles in tumorigenesis. Here, we investigated the m
Publikováno v:
Oncogene. 34:5677-5684
The CCCTC-binding factor (CTCF)/cohesin complex regulates gene transcription via high-order chromatin organization of the genome. De novo methylation of CpG islands in the promoter region is an epigenetic hallmark of gene silencing in cancer. Althoug
Autor:
Eun Goo Jeong, Sae-Won Han, Hwang-Phill Kim, Seock-Ah Im, Tae-You Kim, Min Young Lee, Sang-Hyun Song, Y-J. Bang, Daehee Hwang
Publikováno v:
Oncogene. 33:3334-3341
Human epidermal growth factor receptor 2 (HER2)-directed treatment using trastuzumab has shown clinical benefit in HER2-positive gastric cancer. Clinical trials using lapatinib in HER2-positive gastric cancer are also currently underway. As with othe
Dynamic cohesin-mediated chromatin architecture controls epithelial-mesenchymal plasticity in cancer
Publikováno v:
EMBO reports. 17(9)
Epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET) are important interconnected events in tumorigenesis controlled by complex genetic networks. However, the cues that activate EMT-initiating factors and the mech
Publikováno v:
Drugs. 71:2391-2403
Epigenetic gene silencing is a hallmark of cancer cells. Two important types of epigenetic changes are DNA methylation and histone modification. These modifications are catalysed by DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), res
Autor:
Sang Hyun Song, Do Youn Oh, Hyun Jin Nam, Seock-Ah Im, Maeng Sup Kim, Hyung Seok Hur, Hwang-Phill Kim, Young Kwang Yoon, Tae-You Kim, Sae-Won Han, Yung-Jue Bang, Gwan Sun Lee
Publikováno v:
Cancer letters. 302(2)
Trastuzumab, a HER2 directed treatment has shown clinical benefit in HER2 amplified gastric cancer. This study demonstrated the potent antitumor activity of HM781-36B, a quinazoline-based irreversible pan-HER inhibitor, in HER2 amplified gastric canc
Autor:
Tae-You Kim, Heesun Kim, Sang-Hyun Song, Yeonjoo Jung, Seock-Ah Im, Yung-Jue Bang, Sae-Won Han, Jinah Park, Do-Youn Oh
Publikováno v:
International journal of oncology. 36(6)
DNA methyltransferase (DNMT) 1 and 3 are primarily responsible for abnormal methylation in cancer. Unlike these DNMTs, DNA methyltransferase 3-like (DNMT3L) harbors no conserved catalytic domain, and has been shown to function as a regulatory cofacto