Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Hariharan Easwaran"'
Autor:
Sharon Wu, Elizabeth M. Jaffee, Joanne Xiu, Evanthia T. Roussos Torres, Jerry Lee, Ashani T. Weeraratna, Claudine Isaacs, Michael J. Topper, Jennifer La, Ilya G. Serebriiskii, Igor Astsaturov, Reva Basho, Rossin Erbe, Marc E. Lippman, Elana J. Fertig, Nathanael Fillmore, Hariharan Easwaran, Zheyu Wang, Nicolas A. Giraldo, John Marshall, Josephine A. Taverna, Neeha Zaidi, David Tuck, Stephen B. Baylin, Heinz-Josef Lenz
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110033-(2021)
Cell reports
Cell Reports, Vol 36, Iss 8, Pp 109599-(2021)
Cell reports
Cell Reports, Vol 36, Iss 8, Pp 109599-(2021)
SUMMARY Both tumors and aging alter the immune landscape of tissues. These interactions may play an important role in tumor progression among elderly patients and may suggest considerations for patient care. We leverage large-scale genomic and clinic
Autor:
Yang W. Zhang, Wenbing Xie, Ray Whay Chiu Yen, Hariharan Easwaran, Limin Xia, Yana Li, Zhihong Wang, Yi Cai, Jianjun Luo, Stephen B. Baylin
Publikováno v:
Molecular Cell. 65:323-335
TET proteins, by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), are hypothesized, but not directly shown, to protect promoter CpG islands (CGIs) against abnormal DNA methylation (DNAm) in cancer. We define such a protective role
Autor:
Zhihao, Lu, Jianling, Zou, Shuang, Li, Michael J, Topper, Yong, Tao, Hao, Zhang, Xi, Jiao, Wenbing, Xie, Xiangqian, Kong, Michelle, Vaz, Huili, Li, Yi, Cai, Limin, Xia, Peng, Huang, Kristen, Rodgers, Beverly, Lee, Joanne B, Riemer, Chi-Ping, Day, Ray-Whay Chiu, Yen, Ying, Cui, Yujiao, Wang, Yanni, Wang, Weiqiang, Zhang, Hariharan, Easwaran, Alicia, Hulbert, KiBem, Kim, Rosalyn A, Juergens, Stephen C, Yang, Richard J, Battafarano, Errol L, Bush, Stephen R, Broderick, Stephen M, Cattaneo, Julie R, Brahmer, Charles M, Rudin, John, Wrangle, Yuping, Mei, Young J, Kim, Bin, Zhang, Ken Kang-Hsin, Wang, Patrick M, Forde, Joseph B, Margolick, Barry D, Nelkin, Cynthia A, Zahnow, Drew M, Pardoll, Franck, Housseau, Stephen B, Baylin, Lin, Shen, Malcolm V, Brock
Publikováno v:
Nature. 579(7798)
Cancer recurrence after surgery remains an unresolved clinical problem
Autor:
Fabian M. Johnston, Yen-Yi Juo, Nita Ahuja, Emmanouil P. Pappou, M. van Engeland, Tsung Yu, Hariharan Easwaran, Han Wang, Steve Baylin, H. H. Juo, Dongyu Zhang
Publikováno v:
Annals of Oncology, 25(12), 2314-2327. Oxford University Press
Background Divergent findings regarding the prognostic value of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) patients exist in current literature. We aim to review data from published studies in order to examine the association b
Autor:
Jiang Qian, Dylan Z. Kelley, Daria A. Gaykalova, Alexander V. Favorov, Emily Flam, Heather C. Wick, Luciane T. Kagohara, Elana J. Fertig, Hariharan Easwaran, Genevieve Stein-O’Brien, Ludmila Danilova
Publikováno v:
Briefings in Functional Genomics
Cancer is a complex disease, driven by aberrant activity in numerous signaling pathways in even individual malignant cells. Epigenetic changes are critical mediators of these functional changes that drive and maintain the malignant phenotype. Changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d0b13ef7dbd8bde9336bce36fde098
Publikováno v:
Molecular Cell. 54:716-727
The existence of subpopulations of cells in cancers with increased tumor-initiating capacities and self-renewal potential, often termed "cancer stem cells," is a much discussed and key area of cancer biology. Such cellular heterogeneity is very impor
Autor:
Roisin M. Connolly, Angela A. Guzzetta, Stephen B. Baylin, Vered Stearns, Nancy E. Davidson, Cynthia A. Zahnow, Dennis J. Slamon, Nilofer S. Azad, Rajita Vatapalli, Huili Li, Jianjun Luo, Nita Ahuja, Katherine B. Chiappinelli, Michael J. Topper, Peter A. Jones, Drew M. Pardoll, Ray Whay Chiu Yen, Hariharan Easwaran
Publikováno v:
Oncotarget
// Huili Li 1,* , Katherine B. Chiappinelli 1,* , Angela A. Guzzetta 1,* , Hariharan Easwaran 1 , Ray-Whay Chiu Yen 1 , Rajita Vatapalli 1 , Michael J. Topper 1 , Jianjun Luo 1 , Roisin M. Connolly 1,2 , Nilofer S. Azad 1 , Vered Stearns 1,2 , Drew M
Autor:
Leander Van Neste, Eric A. Collisson, Jingchun Zhu, Srinivasan Yegnasubramanian, Tim Mosbruger, William Matsui, Daniel J. Weisenberger, Sarah E. Johnstone, Martin J. Aryee, Qiuju Wang, Nita Ahuja, Joyce E. Ohm, Patrick Joyce, Hariharan Easwaran, Stephen B. Baylin
Publikováno v:
Genome Research. 22:837-849
Many DNA-hypermethylated cancer genes are occupied by the Polycomb (PcG) repressor complex in embryonic stem cells (ESCs). Their prevalence in the full spectrum of cancers, the exact context of chromatin involved, and their status in adult cell renew
Autor:
Stephen B. Baylin, Subhojit Sen, Leslie Cope, Leander Van Neste, Gayle Jeannette Pageau, Kornel E. Schuebel, Hariharan Easwaran, Jeanne B. Lawrence, Helai P. Mohammad, James G. Herman
Publikováno v:
Cancer Research. 70:8015-8024
Aberrant promoter DNA-hypermethylation and repressive chromatin constitutes a frequent mechanism of gene inactivation in cancer. There is great interest in dissecting the mechanisms underlying this abnormal silencing. Studies have shown changes in th
Autor:
Helai P. Mohammad, Heather M. O'Hagan, Stephen B. Baylin, Joyce E. Ohm, Yi Cai, Hariharan Easwaran, Leander Van Neste, Kelly M. McGarvey
Publikováno v:
Cancer Research. 69:6322-6330
Epigenetic silencing of genes in association with aberrant promoter DNA hypermethylation has emerged as a significant mechanism in the development of human cancers. Such genes are also often targets of the polycomb group repressive complexes in embry