Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Brian Houck-Loomis"'
Autor:
Agnes Viale, Ellinor I.B. Peerschke, Michael Wutkowski, Brian Houck-Loomis, Michael F. Berger, Melissa S. Pessin, Aliaksandra Samoila, Jose Sosa, Jessica Padilla, Katelynd Vanness
Publikováno v:
The Journal of Applied Laboratory Medicine. 5:788-797
Background Cell-free DNA (cfDNA) analysis using peripheral blood represents an exciting, minimally invasive technology for cancer diagnosis and monitoring. The reliability of testing is dependent on the accuracy and sensitivity of specific molecular
Autor:
Maha Shady, Nicholas D. Socci, Julie L. Yang, Helen Won, Maria E. Arcila, Marc Ladanyi, Gopa Iyer, Michael L. Cheng, Xiaohong Jing, Hongxin Zhang, Jonathan Rosenberg, Ahmet Zehir, Pedram Razavi, Kety Huberman, Agnes Viale, Fanli Meng, Darren R. Feldman, Debyani Chakravarty, Michael F. Berger, Venkatraman E. Seshan, S. Duygu Selcuklu, Dennis Stephens, Wassim Abida, Maysun Hasan, Dana E. Rathkopf, Dean F. Bajorin, Erika Gedvilaite, Dana W.Y. Tsui, Preethi Srinivasan, Howard I. Scher, David B. Solit, Juber Patel, Samuel Funt, Ryma Benayed, Ian Johnson, Bob T. Li, Brian Houck-Loomis
Publikováno v:
Genome Medicine
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
BackgroundCell-free DNA (cfDNA) profiling is increasingly used to guide cancer care, yet mutations are not always identified. The ability to detect somatic mutations in plasma depends on both assay sensitivity and the fraction of circulating DNA in p
Autor:
Brian Houck-Loomis, James Cownie, Emiliano Cocco, Elisa de Stanchina, Marc Ladanyi, Kevin Ebata, Ryan Ptashkin, Sandra Misale, Helen Won, Aliaksandra Samoila, Alexander Drilon, Michael F. Berger, Marissa Mattar, David M. Hyman, Juber Patel, Rona Yaeger, Sean Guzman, Richard B. Lanman, Romel Somwar, Alison M. Schram, Jaclyn F. Hechtman, Amanda Kulick, Rebecca J. Nagy, Maurizio Scaltriti, Sophie Shifman, Brian B. Tuch, Pedram Razavi, Eneda Toska, S. Duygu Selcuklu
Publikováno v:
Nature medicine
TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly predict tumor-agnostic efficacy of TRK inhibition1–8. With the recent approval of the first selective TRK inhibitor, larotrectinib, for patients with any
Autor:
Steven T. K. Hill, Rafael C. Schulman, Margaret K. Callahan, Patrick O. Bolan, Gavin Ha, Nicolas Robine, Sunil Deochand, Chelston Ang, Brian Houck-Loomis, Adam J. Widman, Asaf Zviran, Catherine F. Spinelli, Christian Stolte, Viktor A. Adalsteinsson, Alexi M. Runnels, Giorgio Inghirami, Sarah C. Reed, Federico Gaiti, Benchun Miao, Jedd D. Wolchok, Cole C. Khamnei, Nasser K. Altorki, Samantha Fennessey, Murtaza Malbari, Genevieve M. Boland, Will Liao, Dillon Maloney, Jennifer Ishii, Tatyana Sharova, Kevin Y. Huang, Kristofer Patel, Tommy Kim, Nathaniel D. Omans, Denisse Rotem, Dan A. Landau, Andrew Lipsky, Justin Rhoades, Selena Kazancioglu, Greg Gydush, Minita Shah, Phillip Wong, Dennie T. Frederick
Publikováno v:
Nat Med
In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a39e84c85ee6c6a61dd9d8a91de2d20
https://europepmc.org/articles/PMC8108131/
https://europepmc.org/articles/PMC8108131/
Autor:
Gaia Schiavon, Juber Patel, José Baselga, Barry S. Taylor, Lillian M. Smyth, David B. Solit, Salvatore Piscuoglio, Pedram Razavi, Michael F. Berger, Aliaksandra Samoila, Bob T. Li, Brian Houck-Loomis, Jiabin Tang, Duygu Selcuklu, Jorge S. Reis-Filho, David M. Hyman, Daoqi You, Jonathan Reichel, Sarat Chandarlapaty, Fanli Meng
Publikováno v:
JCO Precis Oncol
PURPOSECell-free DNA (cfDNA) analysis offers a noninvasive means to access the tumor genome. Despite limited sensitivity of broad-panel sequencing for detecting low-frequency mutations in cfDNA, it may enable more comprehensive genomic characterizati