Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Xinxin Ding"'
Autor:
Lei Li1, Carratt, Sarah2, Hartog, Matthew3, Kovalchuk, Nataliia1, Kunzhi Jia1, Yanan Wang1, Qing-Yu Zhang1, Edwards, Patricia2, Van Winkle, Laura2 lsvanwinkle@ucdavis.edu, Xinxin Ding3 xding@sunypoly.edu
Publikováno v:
Environmental Health Perspectives. Jun2017, Vol. 125 Issue 6, p1-10. 10p. 2 Diagrams, 2 Charts, 2 Graphs.
Autor:
Nataliia Kovalchuk, Yanan Wang, Matthew Hartog, Sarah A. Carratt, Lei Li, Patricia C. Edwards, Qing Yu Zhang, Xinxin Ding, Laura S. Van Winkle, Kunzhi Jia
Publikováno v:
Environmental health perspectives, vol 125, iss 6
Environmental Health Perspectives
Environmental Health Perspectives
Background: The potential carcinogenicity of naphthalene (NA), a ubiquitous environmental pollutant, in human respiratory tract is a subject of intense debate. Chief among the uncertainties in risk assessment for NA is whether human lung CYP2A13 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cf0f17ae1b890aa1a66416918f7c61
https://escholarship.org/uc/item/0qp5m9mz
https://escholarship.org/uc/item/0qp5m9mz
Publikováno v:
Chemical Research in Toxicology. 26:388-398
The herbicide 2,6-dichlorobenzonitrile (DCBN) is a potent nasal toxicant in rodents; however, it is not known whether DCBN causes similar nasal toxicity in humans. The tissue-selective toxicity of DCBN in mouse nasal mucosa is largely dependent on ta
Autor:
Zhihua Liu, Qing Yu Zhang, Jaime D'Agostino, Xin Zhou, Yuan Wei, Xinxin Ding, Yunyi Yao, Guoyu Ling, Yan Weng, Hong Wu, Lei Li, Kerri Kluetzman, Xiuling Zhang
Publikováno v:
Drug Metabolism and Disposition. 40:1144-1150
CYP2A13, CYP2B6, and CYP2F1, which are encoded by neighboring cytochrome P450 genes on human chromosome 19, are active in the metabolic activation of many drugs, respiratory toxicants, and chemical carcinogens. To facilitate studies on the regulation
Autor:
Dean W. Roberts, Xinxin Ding, Fang Xie, Kerri Kluetzman, Robert C. Karn, Qing Yu Zhang, Christina M. Laukaitis, Jun Gu, Xin Zhou, Yuan Wei
Publikováno v:
Molecular Pharmacology. 79:710-723
To identify novel factors or mechanisms that are important for the resistance of tissues to chemical toxicity, we have determined the mechanisms underlying the previously observed increases in resistance to acetaminophen (APAP) toxicity in the latera
Autor:
Pamela Dalton, Xinxin Ding, Karen K. Yee, Nina Sneitz, Kaisa Laajanen, Xiuling Zhang, Michael H. Court, Moshe Finel
Publikováno v:
Pharmacogenetics and Genomics. 19:923-934
Characterize the expression and glucuronidation activities of the human uridine 5'-diphospho (UDP)-glucuronosyltransferase (UGT) 2A2.UGT2A1 was cloned from nasal mucosa mRNA. Synthetic cDNA for UGT2A2 was constructed assuming exon sharing between UGT
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 117:81-86
To better understand androgen function in the mammalian nose, we have determined the levels of testosterone (T) in the olfactory mucosa (OM, which harbors the olfactory receptor neurons) and the lateral nasal gland (LNG, which is the largest anterior
Autor:
Sharon E. Murphy, Hansen L. Wong, Qing Yu Zhang, Xinxin Ding, Xiuling Zhang, Jun Gu, Stephen S. Hecht
Publikováno v:
Chemical Research in Toxicology. 18:913-918
Among human P450s studied to date, P450 2A13 is the most efficient catalyst of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) alpha-hydroxylation. This reaction is a key bioactivation pathway in NNK-induced carcinogenesis. P450 2A13 mRNA has be
Autor:
Jun Gu, Huadong Cui, Pam Swiatek, Xiaoliang Zhuo, Xinxin Ding, Doris N. Collins, Melissa Behr, Qing Yu Zhang, Yingqiu Xie
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 308:719-728
CYP2G1 is a cytochrome P450 monooxygenase expressed uniquely in the olfactory mucosa (OM). We have generated Cyp2g1-null mice to identify the roles of CYP2G1 in the biology and the tissue-specific toxicity of xenobiotic compounds in the nose. Homozyg
Publikováno v:
Biochemical and Biophysical Research Communications. 289:1225-1228
The aim of this study was to determine whether the NPTA element of the olfactory mucosa-predominant CYP2A3 gene can be activated by NFI-A2, a recently identified member of the nuclear factor 1 family of transcription factors. Isoform-specific RNA-PCR