Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Xinxin Ding"'
Autor:
Pedro Felipe Malacarne, Corina Ratiu, Anna Gajos-Draus, Niklas Müller, Melina Lopez, Beatrice Pflüger-Müller, Xinxin Ding, Timothy Warwick, James Oo, Mauro Siragusa, Carlo Angioni, Stefan Günther, Andreas Weigert, Gerd Geißlinger, Dieter Lütjohann, Wolf-Hagen Schunck, Ingrid Fleming, Ralf P. Brandes, Flávia Rezende
Publikováno v:
Hypertension. 79:1216-1226
Background: POR (cytochrome P450 reductase) provides electrons for the catalytic activity of the CYP (cytochrome P450) monooxygenases. CYPs are dual-function enzymes as they generate protective vasoactive mediators derived from polyunsaturated fatty
Autor:
Senyan Liu, Stewart Sell, Lei Li, Kathleen G. Dickman, Changlin Mei, Xinxin Ding, Xiaochen Bao, Liang Ding, Jun Gu, Qing Yu Zhang
Publikováno v:
Toxicol Sci
The effect of variations in the expression of cytochrome P450 reductase (CPR or POR) is determined in mice with decreased POR expression to identify potential vulnerabilities in people with low POR expression. There is an age-dependent appearance of
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 354:10-17
The potential involvement of intestinal microsomal cytochrome P450 (P450) enzymes in defending against colon inflammation and injury was studied in mice treated with dextran sulfate sodium (DSS) to induce colitis. Wild-type (WT) mice and mice with in
Deficits in neuronal cytochrome P450 activity attenuate opioid analgesia but not opioid side effects
Autor:
Cheng Fang, Lindsay B. Hough, Rachel A. Cleary, Julia W. Nalwalk, Xinxin Ding, Weizhu Yang, James G. Phillips
Publikováno v:
European Journal of Pharmacology. 740:255-262
Morphine-like analgesics act on µ opioid receptors in the CNS to produce highly effective pain relief, but the same class of receptors also mediates non-therapeutic side effects. The analgesic properties of morphine were recently shown to require th
Autor:
Qing Yu Zhang, Lei Li, Laura S. Van Winkle, Patricia C. Edwards, Nataliia Kovalchuk, Xinxin Ding, Matthew Hartog, Jacklyn S. Kelty
We determined whether a decrease in hepatic microsomal cytochrome P450 activity would impact lung toxicity induced by inhalation exposure to naphthalene (NA), a ubiquitous environmental pollutant. The liver-Cpr-null (LCN) mouse showed decreases in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef6068b17672f50c635fff0c9b5b1b2
https://europepmc.org/articles/PMC6398949/
https://europepmc.org/articles/PMC6398949/
Publikováno v:
Molecular Pharmacology. 85:139-147
Tissue-specific deletion of the gene for NADPH-cytochrome P450 (P450) reductase (CPR), the essential electron donor to all microsomal P450 enzymes, in either liver or intestine, leads to upregulation of many P450 genes in the tissue with the Cpr dele
Publikováno v:
Toxicology and Applied Pharmacology. 272:230-237
The kidney is a primary target for numerous toxic compounds. Cytochrome P450 enzymes (P450) are responsible for the metabolic activation of various chemical compounds, and in the kidney are predominantly expressed in proximal tubules. The aim of this
Publikováno v:
Drug Metabolism and Disposition. 41:1782-1786
The aryl hydrocarbon receptor (AHR)-dependent induction of cytochromes P450 (P450) such as CYP1A1 by 3-methylcholanthrene (MC) and related polycyclic aromatic hydrocarbons is well characterized. We reported previously that MC treatment triggers a pro
Publikováno v:
Drug Metabolism and Disposition. 41:529-535
The study was originally designed to test the hypothesis that the compensatory increase in intestinal P450 (cytochrome P450) expression in the intestinal epithelium-specific P450 reductase (CPR) knockout (IE-Cpr-null) mice was attributable to decreas
Publikováno v:
Neuroscience. 218:170-180
The aim of the present study was to test a new hypothesis that brain cytochrome P450 reductase (CPR) and CPR-dependent enzymes play important roles in behavioral performance. A mouse model with brain neuron-specific deletion of the Cpr gene (brain-Cp