Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mauricio J. Reginato"'
Autor:
Dimpi Mukhopadhyay, Neha M. Akella, Zachary A. Bacigalupa, Mauricio J. Reginato, Lorela Ciraku, Valerie L. Sodi, Ayonika Mukherjee, Giang Le Minh
Publikováno v:
Mol Cancer Res
Breast tumors are heterogeneous and composed of different subpopulation of cells, each with dynamic roles that can change with stage, site, and microenvironment. Cellular heterogeneity is, in part, due to cancer stem–like cells (CSC) that share pro
Publikováno v:
Cell Signal
O-GlcNAcylation is a post-translational modification occurring on serine/threonine residues of nuclear and cytoplasmic proteins, mediated by the enzymes OGT and OGA which catalyze the addition or removal of the UDP-GlcNAc moieties, respectively. Stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a24cf855f891788955d5d090a95102
https://europepmc.org/articles/PMC8712408/
https://europepmc.org/articles/PMC8712408/
Autor:
Lorela Ciraku, Zachary A. Bacigalupa, Jing Ju, Rebecca A. Moeller, Giang Le Minh, Rusia H. Lee, Michael D. Smith, Christina M. Ferrer, Sophie Trefely, Luke T. Izzo, Mary T. Doan, Wiktoria A. Gocal, Luca D’Agostino, Wenyin Shi, Joshua G. Jackson, Christos D. Katsetos, Kathryn E. Wellen, Nathaniel W. Snyder, Mauricio J. Reginato
Publikováno v:
Oncogene
Glioblastomas (GBMs) preferentially generate acetyl-CoA from acetate as a fuel source to promote tumor growth. O-GlcNAcylation has been shown to be elevated by increasing O-GlcNAc transferase (OGT) in many cancers and reduced O-GlcNAcylation can bloc
Autor:
Joyce V. Lee, Mircea Ivan, Valerie L. Sodi, Dimpi Mukhopadhyay, Zachary A. Bacigalupa, Mauricio J. Reginato, Kathryn E. Wellen, Wiktoria A. Gocal, Christina M. Ferrer
Publikováno v:
Oncogene
Elevated O-GlcNAcylation is associated with disease states such as diabetes and cancer. O-GlcNAc transferase (OGT) is elevated in multiple cancers and inhibition of this enzyme genetically or pharmacologically inhibits oncogenesis. Here we show that
Autor:
Zachary A. Bacigalupa, Mauricio J. Reginato, David A. Sinclair, Christina M. Ferrer, Tong Y. Lu, Christos D. Katsetos
Publikováno v:
Oncogene
Tumors utilize aerobic glycolysis to support growth and invasion. However, the molecular mechanisms that link metabolism with invasion are not well understood. The nutrient sensor O-linked-β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) modifies
Autor:
Christina M. Ferrer, David J. Vocadlo, John N. Falcone, Tiffany N. Seagroves, Luciana P. Schwab, Valerie L. Sodi, Thomas P. Lynch, Danielle L. Peacock, Mauricio J. Reginato
Publikováno v:
Molecular Cell. 54(5):820-831
The hexosamine biosynthetic pathway elevates posttranslational addition of O-linked β-N-acetylglucosamine (O-GlcNAc) on intracellular proteins. Cancer cells elevate total O-GlcNAcylation by increasing O-GlcNAc transferase (OGT) and/or decreasing O-G
Autor:
Ramana V. Davuluri, Maitri Y. Shah, C. Devlin, M. P. Voorhoeve, Xue Wu, Jana Ferdin, M. S. Nicoloso, George A. Calin, Mircea Ivan, Mauricio J. Reginato, Krishan Kumar, Maria Angelica Cortez, Bogdan Czerniak, Naohiro Nishida, Da Yang, Tanja Kunej, Thomas D. Schmittgen, Wei Zhang, Hui Ling, Massimo Negrini, Y. Bi, Manuela Ferracin, Masayoshi Shimizu
Publikováno v:
Cell Death & Differentiation
Recent data have linked hypoxia, a classic feature of the tumor microenvironment, to the function of specific microRNAs (miRNAs); however, whether hypoxia affects other types of noncoding transcripts is currently unknown. Starting from a genome-wide
Autor:
Tiffany N. Seagroves, Sakina Khaku, Mauricio J. Reginato, Valerie L. Sodi, Raisa I. Krutilina, Luciana P. Schwab, David J. Vocadlo
Cancers exhibit altered metabolism characterized by increased glucose and glutamine uptake. The hexosamine biosynthetic pathway (HBP) uses glucose and glutamine, and directly contributes to O-linked-β-N-acetylglucosamine (O-GlcNAc) modifications on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3854d9e9841b27ff5d6d8e8a8be75ce
https://europepmc.org/articles/PMC4433402/
https://europepmc.org/articles/PMC4433402/
Autor:
Thomas P. Lynch, Christina M. Ferrer, Kristina S. Shahriari, S. RaElle Jackson, Keith Vosseller, Mauricio J. Reginato
Cancer cells universally increase glucose and glutamine consumption, leading to the altered metabolic state known as the Warburg effect; one metabolic pathway, highly dependent on glucose and glutamine, is the hexosamine biosynthetic pathway. Increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c9c305f9ea3f2cc775ecf489050d98
https://europepmc.org/articles/PMC3322861/
https://europepmc.org/articles/PMC3322861/
Autor:
Thomas P. Lynch, Geetika Sethi, S R Jackson, Kristina S. Shahriari, Mauricio J. Reginato, Sarah A. Caldwell, Sarah R. Walker, Keith Vosseller
Publikováno v:
Oncogene. 29(19)
Cancer cells upregulate glycolysis, increasing glucose uptake to meet energy needs. A small fraction of a cell's glucose enters the hexosamine biosynthetic pathway (HBP), which regulates levels of O-linked beta-N-acetylglucosamine (O-GlcNAc), a carbo