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pro vyhledávání: '"Khawaja Husnain Haider"'
Autor:
Khawaja Husnain Haider
Publikováno v:
Regenerative medicine. 13(4)
Nearly two decades of experimental and clinical research with bone marrow cells have paved the way for Phase III pivotal trials in larger groups of heart patients. Despite immense advancements, a multitude of factors are hampering the acceptance of b
Publikováno v:
Regenerative medicine. 12(8)
Stem/progenitor cell-based therapy has been extensively studied for angiomyogenic repair of the ischemic heart by regeneration of the damaged myocytes and neovascularization of the ischemic tissue through biological bypassing. Given their inherent ab
Publikováno v:
Regenerative Medicine. 7:323-334
Aim: To achieve mitochondria-specific expression of connexin-43 (Cx43) transgene for mitochondrial preconditioning in stem cells to improve their survival post-transplantation during heart cell therapy. Methods & results: Cx43- or GFP-encoding adenov
Publikováno v:
Antioxidants & Redox Signaling. 13:1867-1877
The capability of adult tissue-derived stem cells for cardiogenesis has been extensively studied in experimental animals and clinical studies for treatment of postischemic cardiomyopathy. The less-than-anticipated improvement in the heart function in
Publikováno v:
Antioxidantsredox signaling. 16(3)
Aims: To test our hypothesis that the intrinsic molecular mechanism in stem cells for adaptation to ischemia is accentuated by preconditioning with insulin-like growth factor (IGF-1). Results: Bone marrow Sca-1+ cells were exposed to oxygen and gluco
Publikováno v:
Regenerative medicine. 5(6)
Stem cells provide an alternative curative intervention for the infarcted heart by compensating for the cardiomyocyte loss subsequent to myocardial injury. The presence of resident stem and progenitor cell populations in the heart, and nuclear reprog