Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ye Chen-Izu"'
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 31
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 31
Significance The heart autoregulates its contractile strength to maintain cardiac output when pumping blood against the mechanical afterload from vascular resistance. Increased afterload in cardiovascular diseases is associated with cardiac arrhythmi
Publikováno v:
The Journal of Physiology. 598:1275-1277
Autor:
Donald M. Bers, Tamás Bányász, Penelope A. Boyden, Leighton T. Izu, Masahito Miura, Peter Kohl, Nipavan Chiamvimonvat, Natalia A. Trayanova, Ye Chen-Izu
Publikováno v:
The Journal of physiology, vol 598, iss 7
J Physiol
J Physiol
Cardiac excitation-contraction (E-C) coupling is influenced by (at least) three dynamic systems that couple and feedback to one another (Abstract Figure). Here we review the mechanical effects on cardiomyocytes that include mechano-electro-transducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f41721d7c30e03e5f20d2de4616d8aa
https://escholarship.org/uc/item/2dj257vh
https://escholarship.org/uc/item/2dj257vh
Publikováno v:
Biophysical Journal. 111:1304-1315
In the heart, Na + is a key modulator of the action potential, Ca 2+ homeostasis, energetics, and contractility. Because Na + currents and cotransport fluxes depend on the Na + concentration in the submembrane region, it is necessary to accurately es
Autor:
Padmini, Sirish, Hannah A, Ledford, Valeriy, Timofeyev, Phung N, Thai, Lu, Ren, Hyo Jeong, Kim, Seojin, Park, Jeong Han, Lee, Gu, Dai, Maryam, Moshref, Choong-Ryoul, Sihn, Wei Chun, Chen, Maria Valeryevna, Timofeyeva, Zhong, Jian, Rafael, Shimkunas, Leighton T, Izu, Nipavan, Chiamvimonvat, Ye, Chen-Izu, Ebenezer N, Yamoah, Xiao-Dong, Zhang
Publikováno v:
Circulation. Arrhythmia and electrophysiology. 10(10)
Intracellular pH (pHTo test the mechanistic role of Slc26a6 in the heart, we took advantage ofOur study provides mechanistic insights into Slc26a6, a unique cardiac electrogenic Cl
Autor:
Ye, Chen-Izu, Leighton T, Izu
Publikováno v:
The Journal of physiology. 595(12)
The heart has the ability to adjust to changing mechanical loads. The Frank–Starling law and the Anrep effect describe exquisite intrinsic mechanisms the heart has for autoregulating the force of contraction to maintain cardiac output under changes
Autor:
Nipavan Chiamvimonvat, Zhong Jian, Brent M. Wood, Ziliang Mao, Dennis L Matthews, Deborah K. Lieu, Julie Bossuyt, Aaron Lerner, Leighton T. Izu, Rahwa A Woldeyesus, Kit S. Lam, Samir Awasthi, Yi-Je Chen, Ye Chen-Izu, Rafael Shimkunas, James W. Chan, Trevor Landas
Publikováno v:
Circulation research, vol 118, iss 2
Rationale: Cardiac myocyte contraction is caused by Ca 2+ binding to troponin C, which triggers the cross-bridge power stroke and myofilament sliding in sarcomeres. Synchronized Ca 2+ release causes whole cell contraction and is readily observable wi
Autor:
Ye Chen-Izu, Byron Norton, Ling Chen, Tamás Bányász, Leighton T. Izu, Abhijit Patwardhan, Stacey L. McCulle, C. William Balke, Steven M. Scharf, Anuj Agarwal
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 293:H3301-H3310
Hypertension is a major risk factor for developing cardiac hypertrophy and heart failure. Previous studies show that hypertrophied and failing hearts display alterations in excitation-contraction (E-C) coupling. However, it is unclear whether remodel
Publikováno v:
Biophysical Journal. 91(1):95-112
Spontaneously generated calcium (Ca2+) waves can trigger arrhythmias in ventricular and atrial myocytes. Yet, Ca2+ waves also serve the physiological function of mediating global Ca2+ increase and muscle contraction in atrial myocytes. We examine the
Autor:
Sirish, Padmini, Ledford, Hannah A., Timofeyev, Valeriy, Phung N. Thai, Lu Ren, Hyo Jeong Kim, Seojin Park, Jeong Han Lee, Gu Dai, Moshref, Maryam, Choong-Ryoul Sihn, Wei Chun Chen, Timofeyeva, Maria Valeryevna, Zhong Jian, Shimkunas, Rafael, Izu, Leighton T., Chiamvimonvat, Nipavan, Ye Chen-Izu, Yamoah, Ebenezer N., Xiao-Dong Zhang
Publikováno v:
Circulation: Arrhythmia & Electrophysiology; Oct2017, Vol. 10 Issue 10, p1-14, 14p