Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Neil Maclean"'
Autor:
Aaron D. Schimmer, Neil MacLean, Anders Eneroth, Vilma Rraklli, Paul Targett-Adams, Rose Hurren, Aniket Bankar, Marcela Gronda, Pedro Pinho, Mark D. Minden, Simon Kavanagh, Sara Moses, Helen Kylefjord, Johan Bylund, Biljana Rizoska, Mark Albertella, Thirushi Piyumika Siriwardena, Richard Bethell, Christina Rydergård, Xiaoming Wang, Stefan Norin
Publikováno v:
Haematologica
Autor:
Zachary Blatman, Rose Hurren, Neil MacLean, Ahmed Aman, Taira Kiyota, Kazem Nouri, Rima Al-awar, Moustafa Abohawya, Mehakpreet Saini, Karen Arevalo, Samir H. Barghout, Aaron D. Schimmer, Troy Ketela, Geethu E. Thomas
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
JCI Insight
JCI Insight
TAK-243 is a first-in-class inhibitor of ubiquitin-like modifier activating enzyme 1 that catalyzes ubiquitin activation, the first step in the ubiquitylation cascade. Based on its preclinical efficacy and tolerability, TAK-243 has been advanced to p
Autor:
Xiaoming Wang, Danny V. Jeyaraju, Marcela Gronda, Dana Yehudai, Sanduni U. Liyanage, Mark Albertella, Thirushi P. Siriwardena, Samir H. Barghout, Biljana Rizoska, Rose Hurren, Yulia Jitkova, Aaron D. Schimmer, Neil MacLean, Paul Targett-Adams
Publikováno v:
Haematologica
Mitochondrial DNA encodes 13 proteins that comprise components of the respiratory chain that maintain oxidative phosphorylation. The replication of mitochondrial DNA is performed by the sole mitochondrial DNA polymerase γ. As acute myeloid leukemia
Autor:
Geethu E. Thomas, Ayesh K. Seneviratne, Rose Hurren, Neil MacLean, Aaron D. Schimmer, Rashim Pal Singh
Publikováno v:
STAR Protocols
STAR Protocols, Vol 1, Iss 3, Pp 100163-(2020)
STAR Protocols, Vol 1, Iss 3, Pp 100163-(2020)
Summary We describe a method to silence genes in primary acute myeloid leukemia cells by transducing them with shRNA in lentiviral vectors. The transduction of primary non-adherent cells is particularly challenging. The protocol will aid in performin
Autor:
Steven M. Kornblau, Jonathan St-Germain, Yulia Jitkova, Rose Hurren, Aaron Botham, Xiaoming Wang, Steven M. Chan, Yihua Qiu, Gary D. Bader, David Sharon, Andrea Arruda, Marcela Gronda, Terzah M. Horton, Brian Raught, Changjiang Xu, Veronique Voisin, Mark D. Minden, Aaron D. Schimmer, Boaz Nachmias, Fieke W Hoff, Neil MacLean, Sara Mirali
Publikováno v:
Science Translational Medicine, 12(538):8264. AMER ASSOC ADVANCEMENT SCIENCE
Neurolysin (NLN) is a zinc metallopeptidase whose mitochondrial function is unclear. We found that NLN was overexpressed in almost half of patients with acute myeloid leukemia (AML), and inhibition of NLN was selectively cytotoxic to AML cells and st
Autor:
Neil MacLean, Shawn Brennan, Adam C. Smith, Rose Hurren, Allison Berger, Xiaoming Wang, Razq Hakem, Marcela Gronda, Mark D. Minden, Sara Farshchi Zarabi, Simon Kavanagh, Tary Traore, G. Wei Xu, Aaron D. Schimmer, Emil F. Pai, Samir H. Barghout, Ondrej Halgas, Michael Milhollen, Marc L. Hyer, Parasvi S. Patel, Danny V. Jeyaraju
Publikováno v:
Leukemia. 33:37-51
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy for which new therapeutic approaches are required. One such potential therapeutic strategy is to target the ubiquitin-like modifier-activating enzyme 1 (UBA1), the initiating enzyme
Autor:
Dilshad H. Khan, Veronique Voisin, Jonathan St-Germain, Andrea Arruda, Geethu E. Thomas, Changjiang Xu, Rose Hurren, Elias Orouji, Mark D. Minden, Boaz Nachmias, Neil MacLean, Brian Raught, Ayesh K. Seneviratne, Gary D. Bader, Xiaoming Wang, Liran I. Shlush, Aaron D. Schimmer, Aaron Botham
Publikováno v:
Blood. 136:22-23
While most patients with acute myeloid leukemia (AML) achieve remission with initial therapy, the majority relapse leading to poor overall survival. Relapse is frequently driven by a rare subset of leukemic stem cells (LSC). Understanding biological
Autor:
Mathieu Lupien, Yulia Jitkova, Michael Mullokandov, Helen Loo Yau, Rima Al-awar, James R. Hawley, Rose Hurren, Troy Ketela, S. Kim, Veronique Voisin, Neil MacLean, Daniel D. De Carvalho, Mark D. Minden, Geethu E. Thomas, Val A. Fajardo, Ahmed Aman, Zhenyue Hao, Zaza Khuchua, G. Wei Xu, Gary D. Bader, Richard P. Bazinet, Juan J. Aristizabal Henao, Mingjing Xu, Paul J. LeBlanc, Ayesh K. Seneviratne, Steven M. Claypool, Steven M. Chan, Xiaoming Wang, Atan Gross, Aaron D. Schimmer, Ken D. Stark, David Sharon, Raphaël Chouinard-Watkins, Danny V. Jeyaraju, Caitlin Schafer, Marcela Gronda
Summary Tafazzin (TAZ) is a mitochondrial transacylase that remodels the mitochondrial cardiolipin into its mature form. Through a CRISPR screen, we identified TAZ as necessary for the growth and viability of acute myeloid leukemia (AML) cells. Genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b74e60e809d7c98db8697836fef410
https://europepmc.org/articles/PMC7137093/
https://europepmc.org/articles/PMC7137093/
Autor:
Gary D. Bader, Troy Ketela, Veronique Voisin, Danny V. Jeyaraju, Dilshad H. Khan, G. Wei Xu, Sajid A. Marhon, Yulia Jitkova, Michael Mullokandov, Rob C. Laister, Aaron D. Schimmer, Xiaoming Wang, Rose Hurren, Daniel D. De Carvalho, Marcela Gronda, Ayesh K. Seneviratne, Zachary Blatman, Neil MacLean, Mark D. Minden, Atan Gross, Yan Wu
Publikováno v:
Blood. 136(1)
Through a clustered regularly insterspaced short palindromic repeats (CRISPR) screen to identify mitochondrial genes necessary for the growth of acute myeloid leukemia (AML) cells, we identified the mitochondrial outer membrane protein mitochondrial
Autor:
Rose Hurren, Marcela Gronda, Neil MacLean, Feng-Hsu Lin, Alessandro Datti, Lianne E Rotin, Xiaoming Wang, Jeff Wrana, Malik Slassi, Mark D. Minden, Dwayne L. Barber, Aaron D. Schimmer
Publikováno v:
Oncotarget
Targeting Bruton's tyrosine kinase (BTK) with the small molecule BTK inhibitor ibrutinib has significantly improved patient outcomes in several B-cell malignancies, with minimal toxicity. Given the reported expression and constitutive activation of B