Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Annette Schmitt-Graeff"'
Autor:
Shaima’a Hamarsheh, Justus Duyster, Lukas Braun, Franziska M. Uhl, Sandra Duquesne, Geoffroy Andrieux, Robert Zeiser, Melanie Boerries, Annette Schmitt-Graeff, Lena Osswald, Christine Dierks, Tilman Brummer, Claudius Klein
Publikováno v:
Molecular Cancer Research. 19:1596-1608
The bone marrow microenvironment (BMME) is key player in regulation and maintenance of hematopoiesis. Oncogenic RAS mutations, causing constitutive activation of multiple tumor-promoting pathways, are frequently found in human cancer. So far in hemat
Autor:
Franziska M. Uhl, Dietmar Pfeifer, Melanie Boerries, Donatella De Feo, Shaima’a Hamarsheh, Heiko Becker, Benedikt S. Saller, Lena Osswald, Claudia Lengerke, Janaki Manoja Vinnakota, Miriam Erlacher, Geoffroy Andrieux, Justus Duyster, Sandra Duquesne, Robert Zeiser, Martina Konantz, Mark E. Cooper, Annette Schmitt-Graeff, Tilman Brummer, Christoph Schürch, Charlotte M. Niemeyer, Nils Venhoff, Olaf Groß, Michael Lübbert, Khalid Shoumariyeh, Burkhard Becher, Susanne Unger, Bruce R. Blazar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link b
Autor:
Sebastian Halbach, Marina Kreutz, Joy Edwards-Hicks, Melanie Boerries, Justus Duyster, Jörg Büscher, Tobias Madl, Olaf Groß, Sandra Duquesne, David O’Sullivan, Eileen Haring, Wolfgang Melchinger, Gesa Richter, Petya Apostolova, Tilman Brummer, Michael Lübbert, Erika L. Pearce, Franziska M. Uhl, Barbara Sauer, Sophia Chen, Bruce R. Blazar, Geoffroy Andrieux, Robert Zeiser, Annette Schmitt-Graeff, Khalid Shoumariyeh
Publikováno v:
Sci Transl Med
Science translational medicine : integrating medicine and science / American Association for the Advancement of Science
Science translational medicine : integrating medicine and science / American Association for the Advancement of Science
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation (allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML after allo-HCT exhibited reduced glycolysis and interferon-γ production.
Publikováno v:
Essentials of Diagnostic Pathology ISBN: 9783662603079
The descriptive term “Leukamie/leukemia” was introduced by Rudolf Virchow who noticed the “white” color of blood samples obtained from patients presenting with high peripheral white blood cell counts and a reversed white and red blood cell ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30930ae3b6a2465058a1cb7db64dfed8
https://doi.org/10.1007/978-3-662-60309-3_13
https://doi.org/10.1007/978-3-662-60309-3_13
Publikováno v:
Essentials of Diagnostic Pathology ISBN: 9783662603079
Myeloid/lymphoid neoplasms (M/LN) with eosinophilia and gene rearrangement are listed in a distinct WHO category. This category includes three specific disease groups involving rearrangement of platelet-derived growth factor receptor α (PDGFRA), pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4624fb6aa141997aa196009bb80d61f6
https://doi.org/10.1007/978-3-662-60309-3_10
https://doi.org/10.1007/978-3-662-60309-3_10
Publikováno v:
The Journal of Infectious Diseases. 217:1832-1843
Background Chlamydial infection frequently causes damage to the female genital tract. The precise mechanisms of chlamydial clearance and tissue damage are unknown, but studies suggest immunopathology with a particular role of neutrophils. The goal of
Autor:
Anna Lena Illert, Claudia D. Baldus, Teresa Poggio, Cathrin Klingeberg, Peter Paschka, Allan Bradley, George S. Vassiliou, Alina Rudorf, Stefanie Kreutmair, Robert Zeiser, Tamina Rückert, Sivahari P. Gorantla, Justus Duyster, Anina Gengenbacher, Annette Schmitt-Graeff, Tony Andreas Müller
Publikováno v:
Blood
Activating mutations in FMS-like tyrosine kinase receptor-3 (FLT3) and Nucleophosmin-1 (NPM1) are most frequent alterations in acute myeloid leukemia (AML), and are often coincidental. The mutational status of NPM1 has strong prognostic relevance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5efddf9ea07046c4e5a4ab4bae2b447
https://europepmc.org/articles/PMC6659255/
https://europepmc.org/articles/PMC6659255/
Autor:
Gabriele Ihorst, Heiko Becker, Milena Pantic, Silke Kapp-Schwoerer, Justus Duyster, Robert Zeiser, Dietmar Pfeifer, Annette Schmitt-Graeff
Publikováno v:
Leukemia. 33(12)
Autor:
Julia Stomper, Tobias Ma, Annette Schmitt-Graeff, Ruth Meier, Michael Lübbert, Dietmar Pfeifer
Publikováno v:
Blood. 134:1422-1422
Introduction Enhancer of Zeste Homolog 2 (EZH2), the catalytic domain of Polycomb Repressive Complex 2 (PRC2), mediates the repressive mark of trimethylation of histone H3 lysine 27 (H3K27me3). The EZH2 gene is located on chromosome (chr.) 7q36.1 (fr
Autor:
Marie Follo, Melanie Boerries, Melissa Zwick, Justus Duyster, Stefanie Kreutmair, Annette Schmitt-Graeff, Anna Lena Illert, Milena Pantic, Cathrin Klingeberg, Irith Baumann, Bernhard Kuster, Hiroyuki Kawaguchi, Detlev Schindler, Khalid Shoumariyeh, Michal Kulinski, Geoffroy Andrieux, Nina Cabezas-Wallscheid, Dietmar Pfeifer, Rouzanna Istvanffy, Robert Zeiser, Martina Rudelius, Alina Rudorf, Miriam Erlacher, Christian Peschel, Michael D. Cleary, Tony Andreas Müller, Christine Dierks, Robert A.J. Oostendorp, Jesus Duque-Afonso, Teresa Poggio, Simone Lemeer, Charlotte M. Niemeyer, Marcin W. Wlodarski, Tamina Rückert
Publikováno v:
Blood. 134:3741-3741
Inherited bone marrow failure syndromes (IBMFS) are a heterogeneous group of disorders characterized by impaired stem cell function resulting in pancytopenia. Diagnosis of IBMFS presents a major challenge due to limited diagnostic tests and overlappi