Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tsutomu, Yoshida"'
Publikováno v:
Virchows Archiv. 478:507-516
Liquid-based cytology (LBC) specimens of lung adenocarcinoma have the potential to be widely used for genetic analysis. However, formaldehyde contained in some LBC preservation solutions can cause DNA fragmentation during specimen storage, rendering
Publikováno v:
Cancer Cytopathology. 126:1011-1021
Background Liquid-based cytology (LBC) is a useful cytopathological method, and LBC lung adenocarcinoma specimens may be used for genetic analysis in the near future. In the current study, the authors determined whether LBC specimens can be used for
Autor:
Yoshio Matsui, Yukitoshi Satoh, Masahito Naito, Dai Sonoda, Tsutomu Yoshida, Kazu Shiomi, Masashi Mikubo, Yukiko Matsuo
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 144:75-87
Lung adenocarcinomas with a micropapillary pattern (MPP) are characterized by more frequent and pronounced vascular invasion, higher incidence and more advanced lymph node involvement and poorer prognosis than papillary adenocarcinomas without an MPP
Autor:
Masahito Naito, Yukitoshi Satoh, Mariko Sawano, Masashi Mikubo, Dai Sonoda, Yoshio Matsui, Hirotsugu Yamazaki, Kazu Shiomi, Yoshiki Murakumo, Tsutomu Yoshida, Yukiko Matsuo, Tatsuru Kuba, Kazuya Yamashita, Shusaku Tozaka
Publikováno v:
Virchows Archiv : an international journal of pathology. 476(5)
Personalised medicine for primary lung cancers (PLCs) requires molecular analysis of cancer tissue or cells. The primary objective of the present prospective study was to assess the concordance between epidermal growth factor receptor (EGFR) gene mut
Autor:
Takaaki Hasegawa, Akane Horiba, Tsutomu Yoshida, Toshiyuki Sawa, Yohei Futamura, Tsutomu Marui, Takashi Ishiguro
Publikováno v:
Internal Medicine. 54:1977-1980
OBJECTIVE Analyses of tumor biopsy samples from non-small cell lung cancer patients with acquired epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) resistance are expected to reveal the molecular mechanisms of resistance. Howeve
Autor:
Hiroyuki Takahashi, Toshihide Matsumoto, Yuki Tazo, Yoichi Kameda, Hisako Inoue, Tsutomu Yoshida, Makoto Saegusa, Yasuo Takano
Publikováno v:
Human Pathology. 45:33-40
Summary Atypical polypoid adenomyoma (APA) is an uncommon polypoid lesion of the uterus. To clarify the mechanism of its histogenesis, we examined the functional role of β -catenin, with reference to expression of p21 waf1 , cyclin D1, cyclin E, CD1
Autor:
Makoto Saegusa, Tsutomu Yoshida, Kazushige Hayakawa, Noriyuki Masuda, Chun-Ji Piao, Shi-Xu Jiang, Michiko Yamamoto, Atsuko Umezawa, Masato Katagiri, Isao Okayasu, Kazuya Yamashita
Publikováno v:
International Journal of Cancer. 123:2480-2486
Gefitinib is dramatically effective for nonsmall cell lung cancers (NSCLCs) with activating mutations of the epidermal growth factor receptor (EGFR) gene, but these tumors eventually develop drug resistance, attributable to a secondary T790M mutation
Publikováno v:
The Journal of Pathology. 199:166-175
In long-standing ulcerative colitis (UC), p53 mutations have been shown to occur by indirect detection methods such as PCR-SSCP. To clarify whether p53 gene mutations are early events in UC-associated neoplasia and to analyse clonality within dysplas
Publikováno v:
Archives of Pathology & Laboratory Medicine. 125:347-352
Background and Objective.—Abnormal protein expression and gene mutation should be examined on exactly identified lesions. To perform simultaneous analyses of oncogene or tumor suppressor gene mutations and related protein expression in single histo
Publikováno v:
British Journal of Cancer
To clarify the possible role of aberrant β-catenin expression during endometrial tumorigenesis, a total of 199 cases of endometrial carcinomas (endometrioid type), as well as 37 cases of simple/complex and 32 of atypical hyperplasias, was consecutiv