Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Geert J. P. L. Kops"'
Autor:
Lisanne E. Nijman, Cornelis J A Punt, Khalid El Makrini, Erik van Dijk, Bauke Ylstra, Louis Vermeulen, Rebecca C. Fitzgerald, Daniël M. Miedema, Jurriaan B. Tuynman, Tom van den Bosch, Jan Paul Medema, Geert J. P. L. Kops, Hendrik F. van Essen, Michiel Boekhout, Joris H. Hageman, Kristiaan J. Lenos, Hugo J. Snippert, Nico Lansu
Publikováno v:
Nature communications, 12(1):3188. Nature Publishing Group
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, 12(1). Nature Publishing Group
van Dijk, E, van den Bosch, T, Lenos, K J, el Makrini, K, Nijman, L E, van Essen, H F B, Lansu, N, Boekhout, M, Hageman, J H, Fitzgerald, R C, Punt, C J A, Tuynman, J B, Snippert, H J G, Kops, G J P L, Medema, J P, Ylstra, B, Vermeulen, L & Miedema, D M 2021, ' Chromosomal copy number heterogeneity predicts survival rates across cancers ', Nature Communications, vol. 12, no. 1, 3188 . https://doi.org/10.1038/s41467-021-23384-6
Nature Communications, 12(1):3188. Nature Publishing Group
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, 12(1). Nature Publishing Group
van Dijk, E, van den Bosch, T, Lenos, K J, el Makrini, K, Nijman, L E, van Essen, H F B, Lansu, N, Boekhout, M, Hageman, J H, Fitzgerald, R C, Punt, C J A, Tuynman, J B, Snippert, H J G, Kops, G J P L, Medema, J P, Ylstra, B, Vermeulen, L & Miedema, D M 2021, ' Chromosomal copy number heterogeneity predicts survival rates across cancers ', Nature Communications, vol. 12, no. 1, 3188 . https://doi.org/10.1038/s41467-021-23384-6
Nature Communications, 12(1):3188. Nature Publishing Group
Survival rates of cancer patients vary widely within and between malignancies. While genetic aberrations are at the root of all cancers, individual genomic features cannot explain these distinct disease outcomes. In contrast, intra-tumour heterogenei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c5aadebea81d9f17d09ab04b8e9c95
https://www.repository.cam.ac.uk/handle/1810/324542
https://www.repository.cam.ac.uk/handle/1810/324542
Autor:
Ana C.F. Bolhaqueiro, Nizar Hami, Devanjali Dutta, Nobuo Sasaki, Onno Kranenburg, Judith Vivié, Marc van de Wetering, Peter M. Lansdorp, Robert G.J. Vries, Alexander van Oudenaarden, Geert J. P. L. Kops, Hans Clevers, Diana C.J. Spierings, Hugo J. Snippert, Ingrid Verlaan-Klink, Bas Ponsioen, Emre Kucukkose, Richard H. van Jaarsveld, Bjorn Bakker, Sjoerd J Klaasen, Floris Foijer, Sylvia F. Boj
Publikováno v:
Nature Genetics, 51(5), 824-834. Nature Publishing Group
Nature Genetics, 51(5), 824. Nature Publishing Group
Nature Genetics
Nature Genetics, 51(5), 824. Nature Publishing Group
Nature Genetics
Chromosome segregation errors cause aneuploidy and genomic heterogeneity, which are hallmarks of cancer in humans. A persistent high frequency of these errors (chromosomal instability (CIN)) is predicted to profoundly impact tumor evolution and thera
Autor:
Anna Zachariou, Esther Uijttewaal, Shawn Yost, Richarda M. de Voer, Susan Picton, Bas de Wolf, Anna Elliott, Chiara Marcozzi, Sarah F. Smithson, Gunnar Houge, Elise Ruark, Sandra Hanks, Emma Ramsay, Harriet Wylie, Jonathon Pines, Sheila Seal, Nazneen Rahman, Matthew Clarke, Banafsheh Etemad, Geert J. P. L. Kops, Audrey Smith
Publikováno v:
Nature Genetics, 49, 7, pp. 1148-1151
Nature Genetics, 49, 1148-1151
Nature Genetics, 49(7), 1148-1151. Nature Publishing Group
Nature Genetics, 49, 1148-1151
Nature Genetics, 49(7), 1148-1151. Nature Publishing Group
Through exome sequencing, we identified six individuals with biallelic loss-of-function mutations in TRIP13. All six developed Wilms tumor. Constitutional mosaic aneuploidies, microcephaly, developmental delay and seizures, which are features of mosa
Autor:
Gerald Schwank, Arjan Buijs, René M. Overmeer, Norman Sachs, Hugo J. Snippert, Cheryl Zimberlin, Ruben van Boxtel, Harry Begthel, Jeroen Korving, Richard H. van Jaarsveld, Marc van de Wetering, Hans Clevers, Jarno Drost, Meike Logtenberg, Jan Paul Medema, Geert J. P. L. Kops, Edwin Cuppen, G. Johan A. Offerhaus, Bas Ponsioen
Publikováno v:
Nature, 521(7550), 43-37. Nature Publishing Group
Nature, 521(7550), 43-7. Nature Publishing Group
Nature, 521(7550), 43. Nature Publishing Group
Nature, 521(7550), 43-7. Nature Publishing Group
Nature, 521(7550), 43. Nature Publishing Group
Crypt stem cells represent the cells of origin for intestinal neoplasia. Both mouse and human intestinal stem cells can be cultured in medium containing the stem-cell-niche factors WNT, R-spondin, epidermal growth factor (EGF) and noggin over long ti
Autor:
Bas, de Wolf, Geert J P L, Kops
Publikováno v:
Advances in experimental medicine and biology. 1002
The cell cycle culminates in mitosis with the purpose of dividing the cell's DNA content equally over two daughter cells. Error-free segregation relies on correct connections between chromosomes and spindle microtubules. Kinetochores are complex mult
Autor:
René H. Medema, Indra A. Shaltiel, Dipanjan Chowdhury, Adrian T. Saurin, Emile E. Voest, Geert J. P. L. Kops, Melinda Aprelia
Publikováno v:
Proceedings of the National Academy of Sciences. 111:7313-7318
The basic machinery that detects DNA damage is the same throughout the cell cycle. Here, we show, in contrast, that reversal of DNA damage responses (DDRs) and recovery are fundamentally different in G1 and G2 phases of the cell cycle. We find that d
Autor:
Saskia J.E. Suijkerbuijk, Sandra Hanks, Frank L. Bos, Maria H.J. van Osch, Nazneen Rahman, Geert J. P. L. Kops
Publikováno v:
Cancer Research. 70:4891-4900
Genetic mutations in the mitotic regulatory kinase BUBR1 are associated with the cancer-susceptible disorder mosaic variegated aneuploidy (MVA). In patients with biallelic mutations, a missense mutation pairs with a truncating mutation. Here, we show
Autor:
René H. Medema, Carin W.A. Cruijsen, Niels J. F. van den Broek, Susanne M.A. Lens, Maria H.J. van Osch, Geert J. P. L. Kops, Nannette Jelluma, Arjan B. Brenkman
Publikováno v:
Cell. 132:233-246
Summary Maintenance of chromosomal stability relies on coordination between various processes that are critical for proper chromosome segregation in mitosis. Here we show that monopolar spindle 1 (Mps1) kinase, which is essential for the mitotic chec
Publikováno v:
Nature Reviews Cancer. 5:773-785
Abnormal chromosome content - also known as aneuploidy - is the most common characteristic of human solid tumours. It has therefore been proposed that aneuploidy contributes to, or even drives, tumour development. The mitotic checkpoint guards agains
Autor:
Tobias B. Dansen, Karel W. A. Wirtz, Boudewijn M.T. Burgering, Johannes L. Bos, Paul J. Coffer, Ingrid Saarloos, Geert J. P. L. Kops, Paulien E. Polderman, Ting-T. Huang, René H. Medema
Publikováno v:
Nature. 419:316-321
Reactive oxygen species are required for cell proliferation but can also induce apoptosis1. In proliferating cells this paradox is solved by the activation of protein kinase B (PKB; also known as c-Akt), which protects cells from apoptosis2. By contr