Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Hiroshi Nakagawa, Takashi Kijima, Andres J. Klein-Szanto, Koji Tanaka, Kelly A. Whelan, Prasanna M. Chandramouleeswaran, Manti Guha, Gordon Ruthel, Satish Srinivasan, Narayan G. Avadhani, Maura M. Sheehan
Publikováno v:
Oncotarget
Esophageal squamous cell carcinoma (ESCC) is an aggressive cancer with late-stage detection and poor prognosis. This emphasizes the need to identify new markers for early diagnosis and treatment. Altered mitochondrial genome (mtDNA) content in primar
Autor:
Kwok-K Wong, Maureen E. Murphy, Jason R. Pitarresi, Mirazul Islam, Gizem Efe, Tatiana A. Karakasheva, Jianhua Hu, Andres J. Klein-Szanto, Jinyang Li, Taiji Yamazoe, Ben Z. Stanger, Zhenyi Su, Maoting Chen, Adam J. Bass, Wei Gu, Anil K. Rustgi, Jessica C. Leung, Anna M. Chiarella, Shoji Natsugoe, Hiroshi Nakagawa, Samuel Pan, Qiaosi Tang, J. Alan Diehl
Publikováno v:
Genes Dev
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers worldwide and evolves often to lung metastasis. P53R175H (homologous to Trp53R172H in mice) is a common hot spot mutation. How metastasis is regulated by p53R175H in ESCC rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33807ec0bf0ee5cfec8bcbefa93fc57e
https://europepmc.org/articles/PMC8015716/
https://europepmc.org/articles/PMC8015716/
Autor:
Andrea Ventura, Riccardo Fodde, Antonio Percesepe, Alfonso Bellacosa, David P. Turner, Valentina Rovella, Maurizio Ponz de Leon, Karthik Devarajan, Juul T. Wijnen, Maurizio Genuardi, Pietro Mancuso, Salvatore Cortellino, Andres J. Klein-Szanto, Emanuela Lucci-Cordisco, Antonio Riccio, Rossella Tricarico, Heleen M. van der Klift, Pål Møller, Alessandra Viel, Kathy Q. Cai, Monica Pedroni, Paolo Radice, Lucio Bertario, Shantie Jagmohan-Changur, Giovanni Neri
Publikováno v:
Oncotarget
Oncotarget, 6(40), 42892-42904. Impact Journals LLC
Oncotarget, 6(40), 42892-42904. Impact Journals LLC
The DNA glycosylase gene MBD4 safeguards genomic stability at CpG sites and is frequently mutated at coding poly-A tracks in mismatch repair (MMR)-defective colorectal tumors (CRC). Mbd4 biallelic inactivation in mice provided conflicting results as
Autor:
Joseph R. Testa, Jacqueline Talarchek, Erin Neumann-Domer, Deborah A. Altomare, Yue Wu, Craig W. Menges, Guang-Hui Xiao, Vihren N. Kolev, Yuwaraj Kadariya, Irina M. Shapiro, Jonathan A. Pachter, Andres J. Klein-Szanto
Publikováno v:
Cancer Research. 74:1261-1271
Malignant mesothelioma is a highly aggressive, asbestos-related cancer frequently marked by mutations of both NF2 and CDKN2A. We demonstrate that germline knockout of one allele of each of these genes causes accelerated onset and progression of asbes
Autor:
Xiang Xi Xu, Andrew K. Godwin, Andres J. Klein-Szanto, Ying Wang, Toni M. Yeasky, Elizabeth R. Smith, Thomas C. Hamilton, Robert B. Moore, Parvin Ganjei-Azar, Kathy Q. Cai
Publikováno v:
Molecular and cellular biology. 36(18)
We modeled the etiology of postmenopausal biology on ovarian cancer risk using germ cell-deficient white-spotting variant (Wv) mice, incorporating oncogenic mutations. Ovarian cancer incidence is highest in peri- and postmenopausal women, and epidemi
Publikováno v:
Gynecologic Oncology. 114:18-25
Tp53 mutation is frequent and associates with malignant, high-grade ovarian cancer. However, the details about the progression of Tp53 mutation from heterozygous to homozygous, and association between genotypes and morphological transformation are no
Autor:
Mohamed El Dinali, Ravi Salgia, Leslie E. Martin, Ezra E.W. Cohen, James G. Christensen, Mark W. Lingen, Everett E. Vokes, Vidya Nallasura, Tanguy Y. Seiwert, Leonardo Faoro, Andres J. Klein-Szanto, Soheil Yala, Ramasamy Jagadeeswaran, Soundararajan Krishnaswamy, Rajani Kanteti, Varalakshmi Janamanchi
Publikováno v:
Cancer Research. 69:3021-3031
Recurrent/metastatic head and neck cancer remains a devastating disease with insufficient treatment options. We investigated the MET receptor tyrosine kinase as a novel target for the treatment of head and neck squamous cell carcinoma (HNSCC). MET/ph
Autor:
Priya Aggarwal, Douglas I. Lin, Craig H. Bassing, Mariusz A. Wasik, Andrew B. Gladden, Matthew D. Lessie, Laura L. Pontano, Beth Nuskey, J. Alan Diehl, Andres J. Klein-Szanto, Ami Goradia, Anil K. Rustgi
Publikováno v:
Genes & Development. 21:2908-2922
Deregulation of cyclin D1 occurs in numerous human cancers through mutations, alternative splicing, and gene amplification. Although cancer-derived cyclin D1 mutants are potent oncogenes in vitro and in vivo, the mechanisms whereby they contribute to
Autor:
Claudia D. Andl, Anil K. Rustgi, Andres J. Klein-Szanto, Douglas B. Stairs, Jiri Kalabis, Hiroshi Nakagawa, Cameron N. Johnstone, Wafik S. El-Deiry, Takaomi Okawa, Edna Cukierman, Carmen Z. Michaylira, Meenhard Herlyn
Publikováno v:
Genes & Development. 21:2788-2803
Esophageal cancer is a prototypic squamous cell cancer that carries a poor prognosis, primarily due to presentation at advanced stages. We used human esophageal epithelial cells as a platform to recapitulate esophageal squamous cell cancer, thereby p
Autor:
Munenori Takaoka, Carmen Z. Michaylira, Andres J. Klein-Szanto, Hiroshi Nakagawa, Claudia D. Andl, Douglas B. Stairs, Ben Rhoades, Seok-Hyun Kim, Wafik S. El-Deiry, Takaomi Okawa, Cameron N. Johnstone, James J. Lee
Publikováno v:
Cancer Biology & Therapy. 6:534-540
Insulin-like growth factor binding protein (IGFBP)-3 exerts either proapoptotic or growth stimulatory effects depending upon the cellular context. IGFBP-3 is overexpressed frequently in esophageal cancer. Yet, the role of IGFBP-3 in esophageal tumor