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pro vyhledávání: '"Tetsuya Hosooka"'
Autor:
Daisuke Kohno, Gerard Karsenty, Wataru Ogawa, Kazuhiro Nomura, Tetsuya Hosooka, Naoki Kuramoto, Tadahiro Kitamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
Phosphatidylinositol 3-kinase (PI3K) plays an important role in protein metabolism and cell growth. We here show that mice (M-PDK1KO mice) with skeletal muscle–specific deficiency of 3′-phosphoinositide–dependent kinase 1 (PDK1), a key componen
Autor:
Yuko Okada, Wataru Ogawa, Shin'ichi Takeda, Tetsuya Hosooka, Kenta Kobayashi, Yasuhiko Minokoshi, Michihiro Imamura, Yoko Senga, Kazuhiro Nomura, Shiki Okamoto, Yu Hirata
Diabetes mellitus is associated with various disorders of the locomotor system including the decline in mass and function of skeletal muscle. The mechanism underlying this association has remained ambiguous, however. We now show that the abundance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c01fa4131a11ef979de9870c8277088
https://europepmc.org/articles/PMC6478420/
https://europepmc.org/articles/PMC6478420/
Autor:
Takaya Satoh, Nobuyuki Takenaka, Keiko Matsuda, Yukio Sumi, Tetsuya Noguchi, Junko Fujita, Tetsuya Hosooka, Atsu Aiba
Publikováno v:
Biochemical Journal. 469(3):445-454
application/pdf
Biochemical Journal. 2015, 469 (3), P.445-454
Biochemical Journal. 2015, 469 (3), P.445-454
Autor:
Yuma Nihata, Tetsuya Noguchi, Junyuan Wu, Takaya Satoh, Nobuyuki Takenaka, Tetsuya Hosooka, Wataru Ogawa, Atsu Aiba, Rumi Izawa, Kaho Kitagawa
Publikováno v:
The FEBS journalReferences. 281(5)
Insulin promotes glucose uptake in skeletal muscle by inducing the translocation of the glucose transporter GLUT4 to the plasma membrane. The serine/threonine kinase Akt2 has been implicated as a key regulator of this insulin action. However, the mec
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (12):3192-3201
Insulin resistance is characterized as a pathogenic factor in type 2 diabetes. Despite skeletal muscle being primarily responsible for systemic glucose disposal, the mechanisms underlying the induction of insulin resistance in skeletal muscle have no