Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Paul R. Race"'
Autor:
Ashley J. Winter, Matthew T. Rowe, Angus N. M. Weir, Nahida Akter, Sbusisiwe Z. Mbatha, Paul D. Walker, Christopher Williams, Zhongshu Song, Paul R. Race, Christine L. Willis, Matthew P. Crump
Publikováno v:
Winter, A J, Rowe, M T, Weir, A N M, Akter, N, Mbatha, S Z, Walker, P D, Williams, C, Song, Z, Race, P R, Willis, C L & Crump, M P 2022, ' Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin ', Angewandte Chemie-International Edition, vol. 61, no. 50, e202212393 . https://doi.org/10.1002/anie.202212393
Mupirocin is a clinically important antibiotic produced by Pseudomonas fluorescens NCIMB 10586 that is assembled by a complex trans-AT polyketide synthase. The polyketide fragment, monic acid, is esterified by a 9-hydroxynonanoic acid (9HN) side chai
Autor:
Zhongshu Song, Paul R. Race, Thomas J. Simpson, Christine L. Willis, Luoyi Wang, Matthew P. Crump, James Spencer
Publikováno v:
Chemical Science
Wang, L, Song, Z, Race, P R, Spencer, J, Simpson, T J, Crump, M P & Willis, C L 2020, ' Mixing and Matching Genes of Marine and Terrestrial Origin in the Biosynthesis of the Mupirocin Antibiotics ', Chemical Science, vol. 11, pp. 5221-5226 . https://doi.org/10.1039/C9SC06192D
Wang, L, Song, Z, Race, P R, Spencer, J, Simpson, T J, Crump, M P & Willis, C L 2020, ' Mixing and Matching Genes of Marine and Terrestrial Origin in the Biosynthesis of the Mupirocin Antibiotics ', Chemical Science, vol. 11, pp. 5221-5226 . https://doi.org/10.1039/C9SC06192D
With growing understanding of the underlying pathways of polyketide biosynthesis, along with the continual expansion of the synthetic biology toolkit, it is becoming possible to rationally engineer and fine-tune the polyketide biosynthetic machinery
Autor:
Nahida Akter, Matthew T. Rowe, Ashley J. Winter, Christine L. Willis, Christopher Williams, Matthew P. Crump, Thomas J. Simpson, Paul R. Race, Zhongshu Song, Angus N M Weir, Luoyi Wang, Paul D. Walker
Publikováno v:
Walker, P D, Rowe, M T, Winter, A J, Weir, A N M, Akter, N, Wang, L, Race, P R, Williams, C, Song, Z, Simpson, T J, Willis, C L & Crump, M P 2020, ' A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis ', ACS Chemical Biology, vol. 2020 . https://doi.org/10.1021/acschembio.9b00969
Mupirocin, a commercially available antibiotic produced by Pseudomonas fluorescens NCIMB 10586, and thiomarinol, isolated from the marine bacterium Pseudoalteromonas sp. SANK 73390, both consist of a polyketide-derived monic acid homologue esterified
Autor:
Joanne Hothersall, Zhongshu Song, Jack A. Connolly, Thomas J. Simpson, Peter J. Winn, Hadi H. Mohammad, Paul R. Race, Christine L. Willis, Christopher M. Thomas
Publikováno v:
Mohammad, H H, Connolly, J A, Song, Z, Hothersall, J, Race, P R, Willis, C L, Simpson, T J, Winn, P J & Thomas, C M 2018, ' Fine Tuning of Antibiotic Activity by a Tailoring Hydroxylase in a Trans-AT Polyketide Synthase Pathway ', ChemBioChem, vol. 19, no. 8, pp. 836-841 . https://doi.org/10.1002/cbic.201800036
The addition or removal of hydroxy groups modulates the activity of many pharmacologically active biomolecules. It can be integral to the basic biosynthetic factory or result from associated tailoring steps. For the anti-MRSA antibiotic mupirocin, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d2026ceac28f9acda4ee2da1cf8ce8
http://www.scopus.com/inward/record.url?scp=85043569007&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85043569007&partnerID=8YFLogxK
Autor:
Russell J. Cox, Matthew P. Crump, Zhongshu Song, Joanne Hothersall, Elton R. Stevens, Paul R. Race, Thomas J. Simpson, Luoyi Wang, Jack A. Connolly, Peter J. Winn, Shu-Shan Gao, Christine L. Willis, Christopher M. Thomas
Publikováno v:
Gao, S, Wang, L, Song, Z, Hothersall, J, Stevens, E R, Connolly, J, Winn, P J, Cox, R, Crump, M, Race, P, Simpson, T & Willis, C 2017, ' Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics ', Angewandte Chemie-International Edition, vol. 56, no. 14, pp. 3930-3934 . https://doi.org/10.1002/anie.201611590
Thiomarinol and mupirocin are assembled on similar polyketide/fatty acid backbones and exhibit potent antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA). They both contain a tetrasubstituted tetrahydropyran (THP) ring that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdae0bb833e2aa9b8f7435ced5b59a1
https://hdl.handle.net/1983/f0547a69-0a7e-4a53-9162-31b22472b8fe
https://hdl.handle.net/1983/f0547a69-0a7e-4a53-9162-31b22472b8fe
Autor:
Jack A. Connolly, Peter J. Winn, Elton R. Stevens, Zhongshu Song, Shu-Shan Gao, Luoyi Wang, Christine L. Willis, Christopher M. Thomas, Russell J. Cox, Matthew P. Crump, Thomas J. Simpson, Joanne Hothersall, Paul R. Race
Publikováno v:
Angewandte Chemie International Edition. 56:4066-4066
Autor:
Paul R. Race, Christopher M. Thomas, Russell J. Cox, Joanne Hothersall, Zhongshu Song, Luoyi Wang, Jack A. Connolly, Shu-Shan Gao, Peter J. Winn, Elton R. Stevens, Thomas J. Simpson, Christine L. Willis, Matthew P. Crump
Publikováno v:
Angewandte Chemie. 129:4126-4126