Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mark R N Kotter"'
Autor:
Friedrich Altmann, Klaus-Armin Nave, Amparo Acker-Palmer, Yasir Ahmed Syed, Robin J.M. Franklin, Gert Lubec, Aycan Sentürk, Kathryn S. Lilley, Wiebke Möbius, Don J. Mahad, Mark R. N. Kotter, Chao Zhao, Frankziska Foss
Publikováno v:
Acta Neuropathologica
Syed, Y A, Zhao, C, Mahad, D, Möbius, W, Altmann, F, Foss, F, Sentürk, A, Acker-Palmer, A, Lubec, G, Lilley, K, Franklin, R J M, Nave, K-A & Kotter, M R N 2016, ' Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination ', Acta Neuropathologica, vol. 131, no. 2, pp. 281-98 . https://doi.org/10.1007/s00401-015-1521-1
Acta Neuropathol
Syed, Y A, Zhao, C, Mahad, D, Möbius, W, Altmann, F, Foss, F, Sentürk, A, Acker-Palmer, A, Lubec, G, Lilley, K, Franklin, R J M, Nave, K-A & Kotter, M R N 2016, ' Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination ', Acta Neuropathologica, vol. 131, no. 2, pp. 281-98 . https://doi.org/10.1007/s00401-015-1521-1
Acta Neuropathol
Remyelination in multiple sclerosis (MS) lesions often remains incomplete despite the presence of oligodendrocyte progenitor cells (OPCs). Amongst other factors, successful remyelination depends on the phagocytic clearance of myelin debris. However,
Autor:
Mark R. N. Kotter, Chenyi Wang
Publikováno v:
Methods in Molecular Biology ISBN: 9781493978618
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory disease in the central nervous system (CNS) characterized by loss of oligodendrocytes, myelin axons, and neurons. Remyelination is an endogenous repair mechanism, which recovers the loss o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6272a13c97aafc6e8a99548374692e73
https://doi.org/10.1007/978-1-4939-7862-5_18
https://doi.org/10.1007/978-1-4939-7862-5_18
Autor:
Chao Zhao, Mark R. N. Kotter, Elisabeth Hand, Wiebke Möbius, Matthias P. Hofer, Yasir Ahmed Syed, Klaus-Armin Nave
Publikováno v:
The Journal of Neuroscience. 31:3719-3728
Failure of oligodendrocyte precursor cell (OPC) differentiation has been recognized as the leading cause for the failure of myelin regeneration in diseases such as multiple sclerosis (MS). One explanation for the failure of OPC differentiation in MS
Publikováno v:
Glia. 35:204-212
An association between macrophages and remyelination efficiency has been observed in a variety of different models of CNS demyelination. In order to test whether this association is causal or coincidental, we have examined the effects of macrophage d
Autor:
Matthias P. Hofer, Chao Zhao, Alexandra S. Baer, Moritz J. Rossner, Matthew Trotter, Yasir Ahmed Syed, Szymon Myrta, Jon Rundle, Jeffrey K. Huang, Gert Lubec, Mark R. N. Kotter, Robin J.M. Franklin, Ginez A. Gonzalez
Publikováno v:
EMBO Molecular Medicine
Embo Molecular Medicine
Embo Molecular Medicine
The increasing effectiveness of new disease-modifying drugs that suppress\ud disease activity in multiple sclerosis has opened up opportunities for\ud regenerative medicines that enhance remyelination and potentially slow disease\ud progression. Alth
Autor:
Amparo Acker-Palmer, Yasir Ahmed Syed, Robin J.M. Franklin, Gert Lubec, Kathryn S. Lilley, Don J. Mahad, Mark R. N. Kotter, Chao Zhao, Wiebke Möbius, Klaus-A. Nave, Franziska Foss, Aycan Sentürk, Ginez A. Gonzalez, Friedrich Altmann
Publikováno v:
Acta Neuropathologica
Remyelination in multiple sclerosis (MS) lesions often remains incomplete despite the presence of oligodendrocyte progenitor cells (OPCs). Amongst other factors, successful remyelination depends on the phagocytic clearance of myelin debris. However,
Autor:
Mark R. N. Kotter
Publikováno v:
The Qatar International Conference on Stem Cell Science and Policy.
Enhancing the regeneration of myelin sheaths in the central nervous system has been identified as an important therapeutic strategy to ameliorate the devastating consequences of demyelination that occur in diseases such as multiple sclerosis (MS). Fo
Publikováno v:
Brain : a journal of neurology. 134(Pt 7)
Demyelinating disorders of the central nervous system are among the most crippling neurological diseases affecting patients at various stages of life. In the most prominent demyelinating disease, multiple sclerosis, the regeneration of myelin sheaths
Autor:
Alexandra S. Baer, Mark R. N. Kotter, Charles ffrench-Constant, Raluca Vig, Sung Ung Kang, Gert Lubec, Friedrich Altmann, Dieter Mitteregger, Robin J.M. Franklin, Yasir Ahmed Syed
Publikováno v:
Brain
Baer, A S, Syed, Y A, Kang, S U, Mitteregger, D, Vig, R, Ffrench-Constant, C, Franklin, R J M, Altmann, F, Lubec, G & Kotter, M R 2009, ' Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling ', Brain, vol. 132, pp. 465-481 . https://doi.org/10.1093/brain/awn334
Baer, A S, Syed, Y A, Kang, S U, Mitteregger, D, Vig, R, Ffrench-Constant, C, Franklin, R J M, Altmann, F, Lubec, G & Kotter, M R 2009, ' Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling ', Brain, vol. 132, pp. 465-481 . https://doi.org/10.1093/brain/awn334
Failure of oligodendrocyte precursor cell (OPC) differentiation contributes significantly to failed myelin sheath regeneration\ud (remyelination) in chronic demyelinating diseases. Although the reasons for this failure are not completely understood,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580399e5323f2fe766b3a181a2607378
https://orca.cardiff.ac.uk/id/eprint/98439/1/awn334.pdf
https://orca.cardiff.ac.uk/id/eprint/98439/1/awn334.pdf
Autor:
Mark R. N. Kotter, Robin J.M. Franklin
Publikováno v:
Journal of neurology. 255
Remyelination, the process by which new myelin sheaths are restored to demyelinated axons, represents one of the most compelling examples of adult multipotent progenitor cells contributing to regeneration of the injured CNS. This process can occur wi