Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yusuke Yoshioka"'
Autor:
Yoshihisa Shimada, Yusuke Yoshioka, Yujin Kudo, Takahiro Mimae, Yoshihiro Miyata, Hiroyuki Adachi, Hiroyuki Ito, Morihito Okada, Tatsuo Ohira, Jun Matsubayashi, Takahiro Ochiya, Norihiko Ikeda
Publikováno v:
Scientific Reports. 13
Lymphovascular invasion (LVI) is a fundamental step toward the spread of cancer. Extracellular vesicles (EVs) promote cellular communication by shuttling cargo, such as microRNAs (miRNAs). However, whether EV-associated miRNAs serve as biomarkers for
Autor:
Masahiro Morimoto, Taisuke Kawamoto, Chisaho Torii, Takuya Tsumita, Nako Maishi, Yasuhiro Hida, Kosuke Akiyama, Yusuke Yoshioka, Kyoko Hida, Takashi Minami, Mohammad Towfik Alam, Takahiro Ochiya
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Background: Tumor endothelial cells (TECs) reportedly exhibit altered phenotypes. We have demonstrated that TECs acquire drug resistance with the upregulation of p-glycoprotein (p-gp, ABCB1), contrary to traditional assumptions. Furthermore, p-gp exp
Autor:
Mitsutoshi Setou, Koji Ikegami, Tomoaki Kahyo, Akiyoshi Uezumi, Makoto Kinoshita, Kenji Nakamura, Hisateru Yamaguchi, Nobuyoshi Kosaka, Kunihiro Tsuchida, Ozge Karayel, Haruhiko Sugimura, Hiroshi Ageta, Tomihiko Ide, Yutaka Tsutsumi, Takanori Onouchi, Masashi Nakatani, Yusuke Yoshioka, Ken Hatanaka, Takahiro Ochiya, Keisuke Hitachi, Natsumi Ageta-Ishihara, Matthias Mann
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
Exosomes, a type of small extracellular vesicles (sEVs), derived from multivesicular bodies (MVBs), mediate cell-to-cell communication by transporting proteins, mRNAs, and miRNAs. However, the molecular mechanism by which proteins are sorted to sEVs
Autor:
Tomoyoshi Soga, Yusuke Yoshioka, Ryuhei Kudo, Masako Hasebe, Juntaro Matsuzaki, Akiyoshi Hirayama, Takahiro Ochiya, Hiroko Tadokoro, Yusuke Yamamoto, Masahiro Sugimoto
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231430 (2020)
PLoS ONE, Vol 15, Iss 4, p e0231430 (2020)
Extracellular vesicles (EVs) in the tumor microenvironment facilitate intercellular communication. Cancer cell-derived EVs act as an immunosuppressor by transporting cargos and presenting transmembrane proteins. By contrast, CD8+ cytotoxic T-lymphocy
Autor:
Toshihiro Suzuki, Yu Akazawa, Yusuke Yoshioka, Takahiro Ochiya, Norihiro Fujinami, Shoichi Mizuno, Yasunari Nakamoto, Tetsuya Nakatsura
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Biliary tract cancer (BTC) is an aggressive type of malignant tumour. Even after radical resection, the risk of recurrence is still high, resulting in a poor prognosis. Here, we investigated the usefulness of serum miRNAs as predictive markers of rec
Autor:
Kazuhiko Arakawa, Yusuke Yoshioka, Chizuru Iwasawa, Toshiki Aiuchi, Daigo Ikegami, Takahiro Ochiya, Naoko Kuzumaki, Hideyuki Takeshima, Atsumi Nagasawa, Eri Shimura, Michiko Narita, Minoru Narita, Yusuke Hamada, Katsuhide Igarashi, Yukari Suda, Toshikazu Ushijima
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172115 (2017)
PLoS ONE
PLoS ONE
Background The EGFR tyrosine kinase inhibitor gefitinib is used in therapy for non-small-cell lung cancer (NSCLC). However, its application is limited by resistance-accelerated disease progression, which is accompanied by the epithelial-to-mesenchyma
Autor:
Yoshitaka Tamai, Takeshi Katsuda, Yusuke Yoshioka, Aya Yoshimura, Hiroshi Kunugi, Tadahiro Numakawa, Naoki Adachi, Masaki Kawamata, Yoshitaka Nagai, Takahiro Ochiya, Hisae Kikuchi
Publikováno v:
Scientific Reports
Extracellular vesicles (EVs) play an important role in the transfer of biomolecules between cells. To elucidate the intercellular transfer fate of EVs in vivo, we generated a new transgenic (Tg) rat model using green fluorescent protein (GFP)-tagged
Autor:
Akira Yokoi, Takahiro Ochiya, Tohru Kiyono, Hiroaki Kajiyama, Shun ichi Ikeda, Fumitaka Takeshita, Fumitaka Kikkawa, Yusuke Yamamoto, Yusuke Yoshioka, Tomoyasu Kato, Mitsuya Ishikawa
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Advanced ovarian cancers are highly metastatic due to frequent peritoneal dissemination, resulting in dismal prognosis. Here we report the functions of cancer-derived extracellular vesicles (EVs), which are emerging as important mediators of tumour m
Autor:
Takeshi Katsuda, Takahiro Ochiya, Hitoshi Nakagama, Jan Lötvall, Yusuke Yoshioka, Kenji Tamura, Naoomi Tominaga, Nobuyoshi Kosaka, Makiko Ono
Publikováno v:
Nature Communications
Brain metastasis is an important cause of mortality in breast cancer patients. A key event during brain metastasis is the migration of cancer cells through blood–brain barrier (BBB). However, the molecular mechanism behind the passage through this
Autor:
Yusuke Yoshioka, Takashi Kato, Hiroyuki Okamoto, Hajime Sugisaki, Takeshi Nakajima, Masaki Mori, Hiroshi Hayashi, Nobuyoshi Kosaka, Koh Furuta, Fumitaka Takeshita, Hideshi Ishii, Yuki Konishi, Hideki Ohta, Takahiro Ochiya, Hirofumi Yamamoto, Hiroko Higashimoto, Ryoji Nonaka, Hikaru Sonoda
Publikováno v:
Nature Communications
Cancer cells secrete small membranous extracellular vesicles (EVs) into their microenvironment and circulation. Although their potential as cancer biomarkers has been promising, the identification and quantification of EVs in clinical samples remains